The decision to take the Galapagos off UNESCO's danger list suggests the islands are in the clear – but conservationists say that's far from true

The oldest reptile prints ever found suggest that reptiles were the first creatures to venture into continental interiors

Reports suggest that meat and dairy products from the offspring of cloned cattle are already on sale in Europe, says Jessica Griggs

Thanks to thousands of years of skull morphing, the brains of some domestic dogs have shifted and a key component relocated

Electrons trapped inside strain bubbles in graphene act as if they were in an incredibly powerful magnetic field – good news for future electronics

Combining radio transmissions can help robots maintain communications, confounding hostile jammers and overcoming obstacles

A collection of asteroids that orbit the sun along roughly the same path as Neptune may be a source of comets that could hit Earth

A study of the energetic value of food wasted in the US each year shows the scale of the problem

Rachel H. Roberts-Galbraith, Melanie D. Ohi, Bryan A. Ballif, Jun-Song Chen, Ian McLeod, W. Hayes McDonald, Steven P. Gygi, John R. Yates, Kathleen L. Gould. Cytokinesis in Schizosaccharomyces pombe requires the function of Cdc15, the founding member of the pombe cdc15 homology (PCH) family of proteins. As an early, abundant contractile r....

Dong Min Shin, Shmuel Muallem. High-Ca2+ microdomains at ER-mitochondrial junctions have been presumed to exist. Csordás et al. (2010) and Giacomello et al. (2010) report the Ca2+ dynamics at the outer mit....

György Csordás, Péter Várnai, Tünde Golenár, Swati Roy, George Purkins, Timothy G. Schneider, Tamás Balla, György Hajnóczky. The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis. Here, we visualize ER-mitocho....

Jason S. Lee, Yunho Kim, Ik Soo Kim, Bogyou Kim, Hee June Choi, Ji Min Lee, Hi-Jai R. Shin, Jung Hwa Kim, Ji-Young Kim, Sang-Beom Seo, Ho Lee, Olivier Binda, Or Gozani, Gregg L. Semenza, Minhyung Kim, Keun Il Kim, Daehee Hwang, Sung Hee Baek. Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to non....

Haroula Kontaki, Iannis Talianidis. Histone-modifying enzymes can regulate DNA damage-induced apoptosis through modulation of p53 function. Here, we show that, in p53-deficient tumor cells, Set9 and LSD1 regulate DNA damage-induced ....

Raga Krishnakumar, W. Lee Kraus. The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent ....

Agata Smogorzewska, Rohini Desetty, Takamune T. Saito, Michael Schlabach, Francis P. Lach, Mathew E. Sowa, Alan B. Clark, Thomas A. Kunkel, J. Wade Harper, Monica P. Colaiácovo, Stephen J. Elledge. The Fanconi anemia (FA) pathway is responsible for interstrand crosslink repair. At the heart of this pathway is the FANCI-FAND2 (ID) complex, which, upon ubiquitination by the FA core complex, tr....

Yujing Zhang, Danqing Liu, Xi Chen, Jing Li, Limin Li, Zhen Bian, Fei Sun, Jiuwei Lu, Yuan Yin, Xing Cai, Qi Sun, Kehui Wang, Yi Ba, Qiang Wang, Dongjin Wang, Junwei Yang, Pingsheng Liu, Tao Xu, Qiao Yan, Junfeng Zhang, Ke Zen, Chen-Yu Zhang. MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate target gene expression at the posttranscriptional level. Here, we report that secreted miRNAs can serve as signaling molecules mediat....

Adele Adamo, Spencer J. Collis, Carrie A. Adelman, Nicola Silva, Zuzana Horejsi, Jordan D. Ward, Enrique Martinez-Perez, Simon J. Boulton, Adriana La Volpe. Fanconi anemia (FA) is a complex cancer susceptibility disorder associated with DNA repair defects and infertility, yet the precise function of the FA proteins in genome maintenance remains unclea....

Alex S. Flynt, Jaclyn C. Greimann, Wei-Jen Chung, Christopher D. Lima, Eric C. Lai. microRNAs (miRNAs) are ∼22 nucleotide regulatory RNAs derived from hairpins generated either by Drosha cleavage (canonical substrates) or by splicing and debranching of short introns (mirtrons). T....

Hailing Jin, Jian-Kang Zhu. In this issue of Molecular Cell, Lee et al. show that Neuropsora crassa uses several Dicer-dependent and -independent pathways to generate miRNA-like RNAs and small-interfering RNAs.....

Joris J. Benschop, Nathalie Brabers, Dik van Leenen, Linda V. Bakker, Hanneke W.M. van Deutekom, Nynke L. van Berkum, Eva Apweiler, Philip Lijnzaad, Frank C.P. Holstege, Patrick Kemmeren. Analyses of biological processes would benefit from accurate definitions of protein complexes. High-throughput mass spectrometry data offer the possibility of systematically defining protein compl....