QuickGO: a web-based tool for Gene Ontology searching

QuickGO: a web-based tool for Gene Ontology searching - Summary: QuickGO is a web-based tool that allows easy browsing of the Gene Ontology (GO) and all associated electronic and manual GO annotations provided by the GO Consortium annotation groups QuickGO has been a popular GO browser for many year

Phenotypic categorization of genetic skin diseases reveals new relations between phenotypes, genes and pathways

Phenotypic categorization of genetic skin diseases reveals new relations between phenotypes, genes and pathways - Motivation: Systematic analysis of connection between proteins, their cellular function and phenotypic manifestations in disease is a central problem of biological and clinical research.

De novo computational prediction of non-coding RNA genes in prokaryotic genomes

De novo computational prediction of non-coding RNA genes in prokaryotic genomes - Motivation: The computational identification of non-coding RNA (ncRNA) genes represents one of the most important and challenging problems in computational biology.

Zip Nucleic Acids: new high affinity oligonucleotides as potent primers for PCR and reverse transcription

Zip Nucleic Acids: new high affinity oligonucleotides as potent primers for PCR and reverse transcription - Most nucleic acid-based technologies rely upon sequence recognition between an oligonucleotide and its nucleic acid target.

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells - Promoterless gene trap vectors have been widely used for high-efficiency gene targeting and random mutagenesis in embryonic stem (ES) cells.

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases - Specialized DNA polymerases are involved in DNA synthesis during base-excision repair and translesion synthesis across a wide range of chemically modified DNA templates.

RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs

RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs - In both research and therapeutic applications of RNA interference, it is often advantageous to silence several targets simultaneously.

Analysis of splicing patterns by pyrosequencing

Analysis of splicing patterns by pyrosequencing - Several different mRNAs can be produced from a given pre-mRNA by regulated alternative splicing, or as the result of deregulations that may lead to pathological states.

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