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Identification of FAM173B as a protein methyltransferase promoting chronic pain

PLOS Biology (new articles) - чт, 2018-02-15 00:00

by Hanneke L. D. M. Willemen, Annemieke Kavelaars, Judith Prado, Mirjam Maas, Sabine Versteeg, Lara J. J. Nellissen, Jeshua Tromp, Rafael Gonzalez Cano, Wenjun Zhou, Magnus E. Jakobsson, Jędrzej Małecki, George Posthuma, Abdella M. Habib, Cobi J. Heijnen, Pål Ø. Falnes, Niels Eijkelkamp

Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized protein. We demonstrate here that FAM173B is a mitochondrial lysine methyltransferase that promotes chronic pain. Knockdown and sensory neuron overexpression strategies showed that FAM173B is involved in persistent inflammatory and neuropathic pain via a pathway dependent on its methyltransferase activity. FAM173B methyltransferase activity in sensory neurons hyperpolarized mitochondria and promoted macrophage/microglia activation through a reactive oxygen species–dependent pathway. In summary, we uncover a role for methyltransferase activity of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase activity as a potential therapeutic target to treat debilitating chronic pain conditions.
Категории: Biology, Journals

Correction: The Compartmentalized Bacteria of the Planctomycetes-Verrucomicrobia-Chlamydiae Superphylum Have Membrane Coat-Like Proteins

PLOS Biology (new articles) - чт, 2018-02-15 00:00

by Rachel Santarella-Mellwig, Josef Franke, Andreas Jaedicke, Mátyás Gorjánácz, Ulrike Bauer, Aidan Budd, Iain W. Mattaj, Damien P. Devos

Категории: Biology, Journals

Cape Town is about to run out of water – how did this happen?

Genetics - ср, 2018-02-14 20:00
Cape Town's water reserves are so low that it may soon have to turn off the taps. We’ve known for a decade that this could happen, but almost nothing has been done
Категории: Biology

Cape Town is about to run out of water – how did this happen?

HIV and AIDS - ср, 2018-02-14 20:00
Cape Town's water reserves are so low that it may soon have to turn off the taps. We’ve known for a decade that this could happen, but almost nothing has been done
Категории: Healthcare, Science and society

Was SpaceX launch about progress in space, or just a giant ad?

HIV and AIDS - ср, 2018-02-14 20:00
The Falcon Heavy launch was more than just spectacle – it set the stage for a future Mars mission. Now we need to think about who's in the driver's seat
Категории: Healthcare, Science and society

Cape Town is about to run out of water – how did this happen?

Genetically modified organisms (GMO) - ср, 2018-02-14 20:00
Cape Town's water reserves are so low that it may soon have to turn off the taps. We’ve known for a decade that this could happen, but almost nothing has been done
Категории: Science and society

Oceans on alien worlds may form when the air explodes in flames

Genetics - ср, 2018-02-14 18:00
When hydrogen and oxygen combine in a planet’s atmosphere, they can ignite into a ball of fire and then leave behind liquid water oceans that would be good for life
Категории: Biology

Oceans on alien worlds may form when the air explodes in flames

HIV and AIDS - ср, 2018-02-14 18:00
When hydrogen and oxygen combine in a planet’s atmosphere, they can ignite into a ball of fire and then leave behind liquid water oceans that would be good for life
Категории: Healthcare, Science and society

Oceans on alien worlds may form when the air explodes in flames

Genetically modified organisms (GMO) - ср, 2018-02-14 18:00
When hydrogen and oxygen combine in a planet’s atmosphere, they can ignite into a ball of fire and then leave behind liquid water oceans that would be good for life
Категории: Science and society

Drone dogfight crowns a winner in the battle against rogue UAVs

Genetics - ср, 2018-02-14 17:16
Illegal or unwanted drones put air travellers at risk, so a competition called DroneClash is calling for new ways to tackle them
Категории: Biology

Drone dogfight crowns a winner in the battle against rogue UAVs

HIV and AIDS - ср, 2018-02-14 17:16
Illegal or unwanted drones put air travellers at risk, so a competition called DroneClash is calling for new ways to tackle them
Категории: Healthcare, Science and society

Drone dogfight crowns a winner in the battle against rogue UAVs

Genetically modified organisms (GMO) - ср, 2018-02-14 17:16
Illegal or unwanted drones put air travellers at risk, so a competition called DroneClash is calling for new ways to tackle them
Категории: Science and society

Suns and daughters: The family tree that may unite all the stars

Genetics - ср, 2018-02-14 14:30
The chemical make-up of stars tells us a lot about their explosive family history. Unlocking those secrets could reveal how the galaxy got its shape
Категории: Biology

Suns and daughters: The family tree that may unite all the stars

Genetically modified organisms (GMO) - ср, 2018-02-14 14:30
The chemical make-up of stars tells us a lot about their explosive family history. Unlocking those secrets could reveal how the galaxy got its shape
Категории: Science and society

Quantum time machine: How the future can change what happens now

Genetically modified organisms (GMO) - ср, 2018-02-14 14:00
The idea that the future can influence the past may finally explain the inherent randomness of quantum theory and bring it in line with Einstein's space-time
Категории: Science and society

Transgender woman is first to be able to breastfeed her baby

Genetics - ср, 2018-02-14 13:20
An experimental treatment regimen has enabled a transgender woman to exclusively breastfeed her baby for six weeks, during which time the baby grew healthily
Категории: Biology

Transgender woman is first to be able to breastfeed her baby

HIV and AIDS - ср, 2018-02-14 13:20
An experimental treatment regimen has enabled a transgender woman to exclusively breastfeed her baby for six weeks, during which time the baby grew healthily
Категории: Healthcare, Science and society

Transgender woman is first to be able to breastfeed her baby

Genetically modified organisms (GMO) - ср, 2018-02-14 13:20
An experimental treatment regimen has enabled a transgender woman to exclusively breastfeed her baby for six weeks, during which time the baby grew healthily
Категории: Science and society

Valentine’s Day seems to cause a mini baby-boom 9 months later

Genetics - ср, 2018-02-14 12:41
National Health Service data reveals that around Valentine’s Day there is a 5 per cent rise in the number of babies conceived in England
Категории: Biology

Valentine’s Day seems to cause a mini baby-boom 9 months later

Genetically modified organisms (GMO) - ср, 2018-02-14 12:41
National Health Service data reveals that around Valentine’s Day there is a 5 per cent rise in the number of babies conceived in England
Категории: Science and society