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VprBP Has Intrinsic Kinase Activity Targeting Histone H2A and Represses Gene Transcription

Molecular Cell (most read) - чт, 2013-10-17 02:00
Kyunghwan Kim, Jin-Man Kim, Joong-Sun Kim, Jongkyu Choi, Yong Suk Lee, Nouri Neamati, Jin Sook Song, Kyu Heo, Woojin An. Histone modifications play important roles in the regulation of gene expression and chromatin organization. VprBP has been implicated in transcriptionally silent chromatin formation and cell-cycle....

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

Stem Cell: most read - чт, 2013-10-17 02:00
Robert P. Fordham, Shiro Yui, Nicholas R.F. Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J. Schweiger, Ole H. Nielsen, Ludovic Vallier, Roger A. Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B. Jensen. Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here,....
Категории: Biology, Journals, Stem Cells

PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells

Stem Cell: most read - чт, 2013-10-17 02:00
Kamil Matulka, Hsuan-Hwai Lin, Hana Hříbková, Dafe Uwanogho, Petr Dvořák, Yuh-Man Sun. During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate. The molecular mechanisms underlying this role of the Activin/Nodal pathway are not clea....
Категории: Biology, Journals, Stem Cells

Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition

Developmental Cell (most read) - чт, 2013-10-17 02:00
Javier Morante, Diana M. Vallejo, Claude Desplan, Maria Dominguez. Neuroepithelial cell proliferation must be carefully balanced with the transition to neuroblast (neural stem cell) to control neurogenesis. Here, we show that loss of the Drosophila microRN....
Категории: Biology, Journals

Essential N-Terminal Insertion Motif Anchors the ESCRT-III Filament during MVB Vesicle Formation

Developmental Cell (most read) - чт, 2013-10-17 02:00
Nicholas J. Buchkovich, William Mike Henne, Shaogeng Tang, Scott D. Emr. The endosomal sorting complexes required for transport (ESCRTs) have emerged as key cellular machinery that drive topologically unique membrane deformation and scission. Understanding how the ESCR....
Категории: Biology, Journals

Birth Regulates the Initiation of Sensory Map Formation through Serotonin Signaling

Developmental Cell (most read) - пн, 2013-10-14 02:00
Tomohisa Toda, Daigo Homma, Hirofumi Tokuoka, Itaru Hayakawa, Yukihiko Sugimoto, Hiroshi Ichinose, Hiroshi Kawasaki. Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. ....
Категории: Biology, Journals

Local Dkk1 Crosstalk from Breeding Ornaments Impedes Regeneration of Injured Male Zebrafish Fins

Developmental Cell (most read) - пн, 2013-10-14 02:00
Junsu Kang, Gregory Nachtrab, Kenneth D. Poss. Precise spatiotemporal regulation of signaling activators and inhibitors can help limit developmental crosstalk between neighboring tissues during morphogenesis, homeostasis, and regeneration. Her....
Категории: Biology, Journals

The Translational Landscape of the Mammalian Cell Cycle

Molecular Cell (most read) - чт, 2013-10-10 02:00
Craig R. Stumpf, Melissa V. Moreno, Adam B. Olshen, Barry S. Taylor, Davide Ruggero. Gene regulation during cell-cycle progression is an intricately choreographed process, ensuring accurate DNA replication and division. However, the translational landscape of gene expression under....

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

Immunity (most read) - чт, 2013-10-10 02:00
Jun Huang, Mario Brameshuber, Xun Zeng, Jianming Xie, Qi-jing Li, Yueh-hsiu Chien, Salvatore Valitutti, Mark M. Davis. We have developed a single-molecule imaging technique that uses quantum-dot-labeled peptide-major histocompatibility complex (pMHC) ligands to study CD4+ T cell functional sensitivity. ....
Категории: Biology, Healthcare, Immunology, Journals

Epigenetic Modifications Induced by Blimp-1 Regulate CD8+ T Cell Memory Progression during Acute Virus Infection

Immunity (most read) - чт, 2013-10-10 02:00
Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, Leslie J. Berg. The transcription factor Blimp-1 regulates the overall accumulation of virus-specific CD8+ T cells during acute viral infections. We found that increased proliferation and survival of B....
Категории: Biology, Healthcare, Immunology, Journals

Context-Dependent Wiring of Sox2 Regulatory Networks for Self-Renewal of Embryonic and Trophoblast Stem Cells

Molecular Cell (most read) - чт, 2013-10-10 02:00
Kenjiro Adachi, Itoshi Nikaido, Hiroshi Ohta, Satoshi Ohtsuka, Hiroki Ura, Mitsutaka Kadota, Teruhiko Wakayama, Hiroki R. Ueda, Hitoshi Niwa. Sox2 is a transcription factor required for the maintenance of pluripotency. It also plays an essential role in different types of multipotent stem cells, raising the possibility that Sox2 governs....

HDAC5, a Key Component in Temporal Regulation of p53-Mediated Transactivation in Response to Genotoxic Stress

Molecular Cell (most read) - чт, 2013-10-10 02:00
Nirmalya Sen, Rajni Kumari, Manika Indrajit Singh, Sanjeev Das. Despite being one of the most well-studied transcription factors, the temporal regulation of p53-mediated transcription is not very well understood. Recent data suggest that target specificity of ....

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

Molecular Cell (most read) - чт, 2013-10-10 02:00
Lei Lv, Yan-Ping Xu, Di Zhao, Fu-Long Li, Wei Wang, Naoya Sasaki, Ying Jiang, Xin Zhou, Ting-Ting Li, Kun-Liang Guan, Qun-Ying Lei, Yue Xiong. Alternative splicing of the PKM2 gene produces two isoforms, M1 and M2, which are preferentially expressed in adult and embryonic tissues, respectively. The M2 isoform is reexpressed in hum....

Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations

Stem Cell: most read - чт, 2013-10-10 02:00
Peggy Janich, Kiana Toufighi, Guiomar Solanas, Nuno Miguel Luis, Susann Minkwitz, Luis Serrano, Ben Lehner, Salvador Aznar Benitah. Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that....
Категории: Biology, Journals, Stem Cells

Dynamic Analysis of Gene Expression and Genome-wide Transcription Factor Binding during Lineage Specification of Multipotent Progenitors

Stem Cell: most read - чт, 2013-10-10 02:00
Gillian May, Shamit Soneji, Alex J. Tipping, Jose Teles, Simon J. McGowan, Mengchu Wu, Yanping Guo, Cristina Fugazza, John Brown, Göran Karlsson, Cristina Pina, Victor Olariu, Stephen Taylor, Daniel G. Tenen, Carsten Peterson, Tariq Enver. We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells d....
Категории: Biology, Journals, Stem Cells

Characterization of a Proteolytically Stable Multifunctional Host Defense Peptidomimetic

Chemistry and Biology (most read) - чт, 2013-10-10 02:00
Rasmus D. Jahnsen, Evan F. Haney, Henrik Franzyk, Robert E.W. Hancock. The in vitro activity of a host defense peptidomimetic (HDM-4) was investigated. The compound exhibited an antimicrobial activity profile against a range of Gram-negative bacteria. HDM-4 permeabil....
Категории: Biology, Chemistry, Journals

A Cryptic Polyene Biosynthetic Gene Cluster in Streptomyces calvus Is Expressed upon Complementation with a Functional bldA Gene

Chemistry and Biology (most read) - чт, 2013-10-10 02:00
Lindsay Kalan, Arne Gessner, Maulik N. Thaker, Nicholas Waglechner, XiMing Zhu, Anjuli Szawiola, Andreas Bechthold, Gerard D. Wright, David L. Zechel. Streptomyces calvus is best known as the producer of the fluorinated natural product nucleocidin. This strain of Streptomycetes is also unusual for displaying a “bald” phenotype that....
Категории: Biology, Chemistry, Journals

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Molecular Cell (most read) - чт, 2013-10-03 02:00
Zhi-Yang Tsun, Liron Bar-Peled, Lynne Chantranupong, Roberto Zoncu, Tim Wang, Choah Kim, Eric Spooner, David M. Sabatini. The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting t....

Molecular Mechanism of Bacterial Persistence by HipA

Molecular Cell (most read) - чт, 2013-10-03 02:00
Elsa Germain, Daniel Castro-Roa, Nikolay Zenkin, Kenn Gerdes. HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits ....

Metabolic Activation of CaMKII by Coenzyme A

Molecular Cell (most read) - чт, 2013-10-03 02:00
Francis McCoy, Rashid Darbandi, Hoi Chang Lee, Kavitha Bharatham, Tudor Moldoveanu, Christy R. Grace, Keela Dodd, Wenwei Lin, Si-Ing Chen, Rajendra P. Tangallapally, Manabu Kurokawa, Richard E. Lee, Anang A. Shelat, Taosheng Chen, Douglas R. Green, Robert A. Harris, Sue-Hwa Lin, Rafael A. Fissore, Roger J. Colbran, Leta K. Nutt. Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII ....