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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Immunity (most read) - чт, 2013-12-12 02:00
Xin Li, Chang Shu, Guanghui Yi, Catherine T. Chaton, Catherine L. Shelton, Jiasheng Diao, Xiaobing Zuo, C. Cheng Kao, Andrew B. Herr, Pingwei Li. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2′,5′ cGAMP, that binds to STING....
Категории: Biology, Healthcare, Immunology, Journals

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

Stem Cell: most read - чт, 2013-12-12 02:00
Atsuhiro Taguchi, Yusuke Kaku, Tomoko Ohmori, Sazia Sharmin, Minetaro Ogawa, Hiroshi Sasaki, Ryuichi Nishinakamura. Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental origins of the me....
Категории: Biology, Journals, Stem Cells

Solutions to the Public Goods Dilemma in Bacterial Biofilms

Current Biology - чт, 2013-12-12 02:00
Knut Drescher, Carey D. Nadell, Howard A. Stone, Ned S. Wingreen, Bonnie L. Bassler. Bacteria frequently live in densely populated surface-bound communities, termed biofilms [1–4]. Biofilm-dwelling cells rely on secretion of extracellular substances to construct their communities ....
Категории: Biology, Journals

Reward Contexts Extend Dopamine Signals to Unrewarded Stimuli

Current Biology - чт, 2013-12-12 02:00
Shunsuke Kobayashi, Wolfram Schultz. Basic tenets of sensory processing emphasize the importance of accurate identification and discrimination of environmental objects [1]. Although this principle holds also for reward, the crucial a....
Категории: Biology, Journals

An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts

Current Biology - чт, 2013-12-12 02:00
Seth Rakoff-Nahoum, Michael J. Coyne, Laurie E. Comstock. BackgroundThe human intestine is colonized with trillions of microorganisms important to health and disease. There has been an intensive effort to catalog the species and genetic content of this m....
Категории: Biology, Journals

A Mummified Duck-Billed Dinosaur with a Soft-Tissue Cock’s Comb

Current Biology - чт, 2013-12-12 02:00
Phil R. Bell, Federico Fanti, Philip J. Currie, Victoria M. Arbour. Among living vertebrates, soft tissues are responsible for labile appendages (combs, wattles, proboscides) that are critical for activities ranging from locomotion to sexual display [1]. However, ....
Категории: Biology, Journals

Common Origin of Insect Trachea and Endocrine Organs from a Segmentally Repeated Precursor

Current Biology - чт, 2013-12-12 02:00
Carlos Sánchez-Higueras, Sol Sotillos, James Castelli-Gair Hombría. Segmented organisms have serially repeated structures [1] that become specialized in some segments [2]. We show here that the Drosophila corpora allata, prothoracic glands, and trachea have....
Категории: Biology, Journals

Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

Current Biology - чт, 2013-12-12 02:00
Ji Dai, Daniel I. Brooks, David L. Sheinberg. Optogenetics is a recently developed method in which neurons are genetically modified to express membrane proteins sensitive to light, enabling precisely targeted control of neural activity [1–3].....
Категории: Biology, Journals

Vav1 as a Central Regulator of Invadopodia Assembly

Current Biology - чт, 2013-12-12 02:00
Gina L. Razidlo, Barbara Schroeder, Jing Chen, Daniel D. Billadeau, Mark A. McNiven. Invadopodia are protrusive structures used by tumor cells for degradation of the extracellular matrix to promote invasion [1]. Invadopodia formation and function are regulated by cytoskeletal-remo....
Категории: Biology, Journals

cis-Regulatory Requirements for Tissue-Specific Programs of the Circadian Clock

Current Biology - чт, 2013-12-12 02:00
Antonio C.A. Meireles-Filho, Anaïs F. Bardet, J. Omar Yáñez-Cuna, Gerald Stampfel, Alexander Stark. BackgroundBroadly expressed transcriptions factors (TFs) control tissue-specific programs of gene expression through interactions with local TF networks. A prime example is the circadian clock: al....
Категории: Biology, Journals

The Genome of the Foraminiferan Reticulomyxa filosa

Current Biology - чт, 2013-12-12 02:00
Gernot Glöckner, Norbert Hülsmann, Michael Schleicher, Angelika A. Noegel, Ludwig Eichinger, Christoph Gallinger, Jan Pawlowski, Roberto Sierra, Ursula Euteneuer, Loic Pillet, Ahmed Moustafa, Matthias Platzer, Marco Groth, Karol Szafranski, Manfred Schliwa. BackgroundRhizaria are a major branch of eukaryote evolution with an extensive microfossil record, but only scarce molecular data are available. The rhizarian species Reticulomyxa filosa, b....
Категории: Biology, Journals

Feelings about food: the ventral tegmental area in food reward and emotional eating

Trends in Pharmacological Sciences - ср, 2013-12-11 02:00
Frank J. Meye, Roger A.H. Adan.
• Overconsumption of palatable food mediated by three partially overlapping systems acting on midbrain dopamine neurons.
• Energy balance hormones act directly and in....
Категории: Biology, Healthcare, Journals

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

Developmental Cell (most read) - пн, 2013-12-09 02:00
Kathrina L. Marcelo, Tiffany M. Sills, Suleyman Coskun, Hema Vasavada, Supriya Sanglikar, Lauren C. Goldie, Karen K. Hirschi. Delineating the mechanism or mechanisms that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing their derivation from human stem cells....
Категории: Biology, Journals

A Mesodermal Factor, T, Specifies Mouse Germ Cell Fate by Directly Activating Germline Determinants

Developmental Cell (most read) - пн, 2013-12-09 02:00
Shinya Aramaki, Katsuhiko Hayashi, Kazuki Kurimoto, Hiroshi Ohta, Yukihiro Yabuta, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Yuki Kato, Katsuhiko Shirahige, Mitinori Saitou. Germ cells ensure reproduction and heredity. In mice, primordial germ cells (PGCs), the precursors for spermatozoa and oocytes, are induced in pluripotent epiblast by BMP4 and WNT3, yet the underl....
Категории: Biology, Journals

Location, Location, Location: Macrophage Positioning within Tumors Determines Pro- or Antitumor Activity

Cancer Cell - пн, 2013-12-09 02:00
Lee B. Rivera, Gabriele Bergers. Macrophages infiltrate hypoxic tumor regions, where they promote angiogenesis and immunosuppression. In this issue of Cancer Cell, Casazza and colleagues report that tumor-associated macrop....
Категории: Biology, Cancer, Journals

RAS and ROS in Rhabdomyosarcoma

Cancer Cell - пн, 2013-12-09 02:00
Minsi Zhang, Corinne M. Linardic, David G. Kirsch. The 5-year survival for localized rhabdomyosarcoma is over 70%, but only 30% for patients presenting with metastatic disease. In this issue of Cancer Cell, Chen and colleagues performed who....
Категории: Biology, Cancer, Journals

A Novel Bullet Hits the Proteasome

Cancer Cell - пн, 2013-12-09 02:00
Alexei F. Kisselev. An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessent....
Категории: Biology, Cancer, Journals

The Evolution of Tumor Classification: A Role for Genomics?

Cancer Cell - пн, 2013-12-09 02:00
Paul A. Bunn, Wilbur Franklin, Robert C. Doebele. Lung cancers are divided into four types according to their histologic appearance. Therapeutic decisions are partly based on histology. A recent study indicates that certain molecular alterations ....
Категории: Biology, Cancer, Journals

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

Cancer Cell - пн, 2013-12-09 02:00
Andrea Casazza, Damya Laoui, Mathias Wenes, Sabrina Rizzolio, Nicklas Bassani, Marco Mambretti, Sofie Deschoemaeker, Jo A. Van Ginderachter, Luca Tamagnone, Massimiliano Mazzone. Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor progression; however, the underlying guidance mechanisms are unknown. Here, we report that hypoxia-induced Se....
Категории: Biology, Cancer, Journals

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

Cancer Cell - пн, 2013-12-09 02:00
Xiang Chen, Elizabeth Stewart, Anang A. Shelat, Chunxu Qu, Armita Bahrami, Mark Hatley, Gang Wu, Cori Bradley, Justina McEvoy, Alberto Pappo, Sheri Spunt, Marcus B. Valentine, Virginia Valentine, Fred Krafcik, Walter H. Lang, Monika Wierdl, Lyudmila Tsurkan, Viktor Tolleman, Sara M. Federico, Chris Morton, Charles Lu, Li Ding, John Easton, Michael Rusch, Panduka Nagahawatte, Jianmin Wang, Matthew Parker, Lei Wei, Erin Hedlund, David Finkelstein, Michael Edmonson, Sheila Shurtleff, Kristy Boggs, Heather Mulder, Donald Yergeau, Steve Skapek, Douglas S. Hawkins, Nilsa Ramirez, Philip M. Potter, John A. Sandoval, Andrew M. Davidoff, Elaine R. Mardis, Richard K. Wilson, Jinghui Zhang, James R. Downing, Michael A. Dyer. Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with ....
Категории: Biology, Cancer, Journals