Robert P. Fordham, Shiro Yui, Nicholas R.F. Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J. Schweiger, Ole H. Nielsen, Ludovic Vallier, Roger A. Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B. Jensen. Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here,....

Kamil Matulka, Hsuan-Hwai Lin, Hana Hříbková, Dafe Uwanogho, Petr Dvořák, Yuh-Man Sun. During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate. The molecular mechanisms underlying this role of the Activin/Nodal pathway are not clea....

Peggy Janich, Kiana Toufighi, Guiomar Solanas, Nuno Miguel Luis, Susann Minkwitz, Luis Serrano, Ben Lehner, Salvador Aznar Benitah. Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that....

Gillian May, Shamit Soneji, Alex J. Tipping, Jose Teles, Simon J. McGowan, Mengchu Wu, Yanping Guo, Cristina Fugazza, John Brown, Göran Karlsson, Cristina Pina, Victor Olariu, Stephen Taylor, Daniel G. Tenen, Carsten Peterson, Tariq Enver. We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells d....

Maria Ester Bernardo, Willem E. Fibbe. In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treati....

Kevin Rouault-Pierre, Lourdes Lopez-Onieva, Katie Foster, Fernando Anjos-Afonso, Isabelle Lamrissi-Garcia, Martin Serrano-Sanchez, Richard Mitter, Zoran Ivanovic, Hubert de Verneuil, John Gribben, David Taussig, Hamid Reza Rezvani, Frédéric Mazurier, Dominique Bonnet. Hematopoietic stem and progenitor cells (HSPCs) are exposed to low levels of oxygen in the bone marrow niche, and hypoxia-inducible factors (HIFs) are the main regulators of cellular responses to ....

Sergei Doulatov, Linda T. Vo, Stephanie S. Chou, Peter G. Kim, Natasha Arora, Hu Li, Brandon K. Hadland, Irwin D. Bernstein, James J. Collins, Leonard I. Zon, George Q. Daley. Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells for disease modeling, drug screens, and cellular therapies. However, the inability to derive engraftable....

Karine Rizzoti, Haruhiko Akiyama, Robin Lovell-Badge. Pituitary hormone deficiencies, with Growth Hormone deficiency being most frequent (1 in 3,500-10,000 births), cause significant morbidity. Regeneration of missing endocrine cells would be a signi....