Stem Cells

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

Stem Cell: most read - чт, 2013-10-17 02:00
Robert P. Fordham, Shiro Yui, Nicholas R.F. Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J. Schweiger, Ole H. Nielsen, Ludovic Vallier, Roger A. Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B. Jensen. Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here,....
Категории: Biology, Journals, Stem Cells

PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells

Stem Cell: most read - чт, 2013-10-17 02:00
Kamil Matulka, Hsuan-Hwai Lin, Hana Hříbková, Dafe Uwanogho, Petr Dvořák, Yuh-Man Sun. During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate. The molecular mechanisms underlying this role of the Activin/Nodal pathway are not clea....
Категории: Biology, Journals, Stem Cells

Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations

Stem Cell: most read - чт, 2013-10-10 02:00
Peggy Janich, Kiana Toufighi, Guiomar Solanas, Nuno Miguel Luis, Susann Minkwitz, Luis Serrano, Ben Lehner, Salvador Aznar Benitah. Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that....
Категории: Biology, Journals, Stem Cells

Dynamic Analysis of Gene Expression and Genome-wide Transcription Factor Binding during Lineage Specification of Multipotent Progenitors

Stem Cell: most read - чт, 2013-10-10 02:00
Gillian May, Shamit Soneji, Alex J. Tipping, Jose Teles, Simon J. McGowan, Mengchu Wu, Yanping Guo, Cristina Fugazza, John Brown, Göran Karlsson, Cristina Pina, Victor Olariu, Stephen Taylor, Daniel G. Tenen, Carsten Peterson, Tariq Enver. We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells d....
Категории: Biology, Journals, Stem Cells

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

Stem Cell: most read - чт, 2013-10-03 02:00
Maria Ester Bernardo, Willem E. Fibbe. In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treati....
Категории: Biology, Journals, Stem Cells

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

Stem Cell: most read - чт, 2013-10-03 02:00
Kevin Rouault-Pierre, Lourdes Lopez-Onieva, Katie Foster, Fernando Anjos-Afonso, Isabelle Lamrissi-Garcia, Martin Serrano-Sanchez, Richard Mitter, Zoran Ivanovic, Hubert de Verneuil, John Gribben, David Taussig, Hamid Reza Rezvani, Frédéric Mazurier, Dominique Bonnet. Hematopoietic stem and progenitor cells (HSPCs) are exposed to low levels of oxygen in the bone marrow niche, and hypoxia-inducible factors (HIFs) are the main regulators of cellular responses to ....
Категории: Biology, Journals, Stem Cells

Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors

Stem Cell: most read - чт, 2013-10-03 02:00
Sergei Doulatov, Linda T. Vo, Stephanie S. Chou, Peter G. Kim, Natasha Arora, Hu Li, Brandon K. Hadland, Irwin D. Bernstein, James J. Collins, Leonard I. Zon, George Q. Daley. Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells for disease modeling, drug screens, and cellular therapies. However, the inability to derive engraftable....
Категории: Biology, Journals, Stem Cells

Mobilized Adult Pituitary Stem Cells Contribute to Endocrine Regeneration in Response to Physiological Demand

Stem Cell: most read - чт, 2013-10-03 02:00
Karine Rizzoti, Haruhiko Akiyama, Robin Lovell-Badge. Pituitary hormone deficiencies, with Growth Hormone deficiency being most frequent (1 in 3,500-10,000 births), cause significant morbidity. Regeneration of missing endocrine cells would be a signi....
Категории: Biology, Journals, Stem Cells