Consolidated strategy for the analysis of microarray spike-in data

Consolidated strategy for the analysis of microarray spike-in data - As the number of users of microarray technology continues to grow, so does the importance of platform assessments and comparisons.

MotifVoter: a novel ensemble method for fine-grained integration of generic motif finders

MotifVoter: a novel ensemble method for fine-grained integration of generic motif finders - Motivation: Locating transcription factor binding sites (motifs) is a key step in understanding gene regulation.

Fast and accurate search for non-coding RNA pseudoknot structures in genomes

Fast and accurate search for non-coding RNA pseudoknot structures in genomes - Motivation: Searching genomes for non-coding RNAs (ncRNAs) by their secondary structure has become an important goal for bioinformatics.

An approach of orthology detection from homologous sequences under minimum evolution

An approach of orthology detection from homologous sequences under minimum evolution - In the field of phylogenetics and comparative genomics, it is important to establish orthologous relationships when comparing homologous sequences.

A probabilistic generative model for GO enrichment analysis

A probabilistic generative model for GO enrichment analysis - The Gene Ontology (GO) is extensively used to analyze all types of high-throughput experiments. However, researchers still face several challenges when using GO and other functional annotation databases.

De novo DNA synthesis using single molecule PCR

De novo DNA synthesis using single molecule PCR - The throughput of DNA reading (sequencing) has dramatically increased recently due to the incorporation of in vitro clonal amplification.

Specific ligation to double-stranded RNA for analysis of cellular RNA::RNA interactions

Specific ligation to double-stranded RNA for analysis of cellular RNA::RNA interactions - Double-stranded RNA (dsRNA) is formed in cells as intra- and intermolecular RNA interactions and is involved in a range of biological processes including RNA metabolism, RNA interference and translation control mediated by natura

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch - Applications of conditional gene expression, whether for therapeutic or basic research purposes, are increasingly requiring mammalian gene control systems that exhibit far tighter control properties.

Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli

Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli - Now that many genomes have been sequenced and the products of newly identified genes have been annotated, the next goal is to engineer the desired phenotypes in organisms of interest.

Transduction of artificial transcriptional regulatory proteins into human cells

Transduction of artificial transcriptional regulatory proteins into human cells - Protein transduction (PT) is a method for delivering proteins into mammalian cells.