CoCoa: a software tool for estimating the coefficient of coancestry from multilocus genotype data

CoCoa: a software tool for estimating the coefficient of coancestry from multilocus genotype data - Motivation: Phenotypic data collected in breeding programs and marker-trait association studies are often analyzed by means of linear mixed models.

Separation of 1-23-kb complementary DNA strands by urea-agarose gel electrophoresis

Separation of 1-23-kb complementary DNA strands by urea-agarose gel electrophoresis - Double-stranded (ds), as well as denatured, single-stranded (ss) DNA samples can be analyzed on urea–agarose gels.

Extracting transcription factor targets from ChIP-Seq data

Extracting transcription factor targets from ChIP-Seq data - ChIP-Seq technology, which combines chromatin immunoprecipitation (ChIP) with massively parallel sequencing, is rapidly replacing ChIP-on-chip for the genome-wide identification of transcription factor binding events.

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life - RNA levels in a cell are regulated by the relative rates of RNA synthesis and decay.

Preparation of selective and segmentally labeled ssDNA for NMR by self-primed PCR & asymmetrical endonuclease double digestion

Preparation of selective and segmentally labeled single-stranded DNA for NMR by self-primed PCR and asymmetrical endonuclease double digestion - We demonstrate a new, efficient and easy-to-use method for enzymatic synthesis of (stereo-)specific and segmental 13C/15N/2H isotope-labeled

Upcoming challenges for multiple sequence alignment methods in the high-throughput era

Upcoming challenges for multiple sequence alignment methods in the high-throughput era - This review focuses on recent trends in multiple sequence alignment tools.

Relationship between gene co-expression and sharing of transcription factor binding sites in Drosophila melanogaster

Relationship between gene co-expression and sharing of transcription factor binding sites in Drosophila melanogaster - Motivation: In functional genomics, it is frequently useful to correlate expression levels of genes to identify transcription factor binding sites (TFBS) via the presence of common

An algorithm for learning maximum entropy probability models of disease risk that encodes multilocus genomic interactions

An algorithm for learning maximum entropy probability models of disease risk that efficiently searches and sparingly encodes multilocus genomic interactions - Motivation: In both genome-wide association studies (GWAS) and pathway analysis, the modest sample size relative to the number of genetic mar