Copy number variation has little impact on bead-array-based measures of DNA methylation - Motivation: Integration of various genome-scale measures of molecular alterations is of great interest to researchers aiming to better define disease processes or identify novel targets with clinical utility.
A pattern-based nearest neighbor search approach for promoter prediction using DNA structural profiles - Motivation: Identification of core promoters is a key clue in understanding gene regulations.
PROMISE: a tool to identify genomic features with a specific biologically interesting pattern of associations with multiple endpoint variables - Motivation: In some applications, prior biological knowledge can be used to define a specific pattern of association of multiple endpoint variables with a
An investigation into the population abundance distribution of mRNAs, proteins, and metabolites in biological systems - Motivation: Distribution analysis is one of the most basic forms of statistical analysis.
A statistical framework for protein quantitation in bottom-up MS-based proteomics - Motivation: Quantitative mass spectrometry-based proteomics requires protein-level estimates and associated confidence measures.