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Google’s takeover of health app appears to renege on DeepMind promises

HIV and AIDS - Wed, 2018-11-14 13:55
DeepMind used 1.6 million patient records from the NHS to develop its Streams app. Now Google is taking over and wants to develop a digital hospital assistant

Google’s takeover of health app appears to renege on DeepMind promises

Genetics - Wed, 2018-11-14 13:55
DeepMind used 1.6 million patient records from the NHS to develop its Streams app. Now Google is taking over and wants to develop a digital hospital assistant
Categories: Biology

Google’s takeover of health app appears to renege on DeepMind promises

Genetically modified organisms (GMO) - Wed, 2018-11-14 13:55
DeepMind used 1.6 million patient records from the NHS to develop its Streams app. Now Google is taking over and wants to develop a digital hospital assistant
Categories: Science and society

The Galapagos of the Indian Ocean: Voyage to a forgotten paradise

Genetically modified organisms (GMO) - Wed, 2018-11-14 13:50
Celebrated for their biodiversity, the islands of Socotra could unlock secrets of humans' journey out of Africa – but war and weather hamper the journey there
Categories: Science and society

The Galapagos of the Indian Ocean: Voyage to a forgotten paradise

Genetics - Wed, 2018-11-14 13:50
Celebrated for their biodiversity, the islands of Socotra could unlock secrets of humans' journey out of Africa – but war and weather hamper the journey there
Categories: Biology

On the importance of monitoring and valuing all forms of biodiversity

PLOS Biology (new articles) - Wed, 2018-11-14 00:00

by Martin A. Schlaepfer

Pauchard et al claim that non-native species should not be granted conservation value, as this could hinder effort to curtail novel introductions. In this response, Schlaepfer counters that the positive contributions of non-native species to biodiversity and conservation must be included to provide a complete and objective snapshot to policy makers.
Categories: Biology, Journals

Biodiversity assessments: Origin matters

PLOS Biology (new articles) - Wed, 2018-11-14 00:00

by Aníbal Pauchard, Laura A. Meyerson, Sven Bacher, Tim M. Blackburn, Giuseppe Brundu, Marc W. Cadotte, Franck Courchamp, Franz Essl, Piero Genovesi, Sylvia Haider, Nick D. Holmes, Philip E. Hulme, Jonathan M. Jeschke, Julie L. Lockwood, Ana Novoa, Martin A. Nuñez, Duane A. Peltzer, Petr Pyšek, David M. Richardson, Daniel Simberloff, Kevin Smith, Brian W. van Wilgen, Montserrat Vilà, John R. U. Wilson, Marten Winter, Rafael D. Zenni

Categories: Biology, Journals

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

PLOS Biology (new articles) - Wed, 2018-11-14 00:00

by Lijun Wang, Ningning Niu, Li Li, Rui Shao, Huiling Ouyang, Weiguo Zou

During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here, we report that the H3 lysine 36 trimethylation (H3K36me3), catalyzed by histone methyltransferase SET-domain-containing 2 (SETD2), regulates lineage commitment of BMSCs. Deletion of Setd2 in mouse bone marrow mesenchymal stem cells (mBMSCs), through conditional Cre expression driven by Prx1 promoter, resulted in bone loss and marrow adiposity. Loss of Setd2 in BMSCs in vitro facilitated differentiation propensity to adipocytes rather than to osteoblasts. Through conjoint analysis of RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) data, we identified a SETD2 functional target gene, Lbp, on which H3K36me3 was enriched, and its expression was affected by Setd2 deficiency. Furthermore, overexpression of lipopolysaccharide-binding protein (LBP) could partially rescue the lack of osteogenesis and enhanced adipogenesis resulting from the absence of Setd2 in BMSCs. Further mechanistic studies demonstrated that the trimethylation level of H3K36 could regulate Lbp transcriptional initiation and elongation. These findings suggest that H3K36me3 mediated by SETD2 could regulate the cell fate of mesenchymal stem cells (MSCs) in vitro and in vivo, indicating that the regulation of H3K36me3 level by targeting SETD2 and/or the administration of downstream LBP may represent a potential therapeutic way for new treatment in metabolic bone diseases, such as osteoporosis.
Categories: Biology, Journals

China may have developed a quantum radar that can spot stealth planes

HIV and AIDS - Tue, 2018-11-13 19:00
A defence firm has unveiled a prototype quantum radar. If it works, it could use entangled protons to locate stealth aircraft that normally avoid detection

China may have developed a quantum radar that can spot stealth planes

Genetics - Tue, 2018-11-13 19:00
A defence firm has unveiled a prototype quantum radar. If it works, it could use entangled protons to locate stealth aircraft that normally avoid detection
Categories: Biology

China may have developed a quantum radar that can spot stealth planes

Genetically modified organisms (GMO) - Tue, 2018-11-13 19:00
A defence firm has unveiled a prototype quantum radar. If it works, it could use entangled protons to locate stealth aircraft that normally avoid detection
Categories: Science and society

Mystery “space cow” is a weird new type of powerful space explosion

HIV and AIDS - Tue, 2018-11-13 18:15
Months of observations have shown that the strange explosion in space called “the Cow” gets extra power from within, making it a new type of celestial event

Mystery “space cow” is a weird new type of powerful space explosion

Genetics - Tue, 2018-11-13 18:15
Months of observations have shown that the strange explosion in space called “the Cow” gets extra power from within, making it a new type of celestial event
Categories: Biology

Mystery “space cow” is a weird new type of powerful space explosion

Genetically modified organisms (GMO) - Tue, 2018-11-13 18:15
Months of observations have shown that the strange explosion in space called “the Cow” gets extra power from within, making it a new type of celestial event
Categories: Science and society

Stan Lee’s legacy isn’t just superheroes but the humanity he gave them

Genetics - Tue, 2018-11-13 17:58
The Marvel comics legend has died aged 95. The creative force behind Spider-Man, Iron Man, The Incredible Hulk, Avengers, Thor, X-Men and many more, Lee's influence on culture was huge - but let's not overlook his impact on our humanity
Categories: Biology

Stan Lee’s legacy isn’t just superheroes but the humanity he gave them

Genetically modified organisms (GMO) - Tue, 2018-11-13 17:58
The Marvel comics legend has died aged 95. The creative force behind Spider-Man, Iron Man, The Incredible Hulk, Avengers, Thor, X-Men and many more, Lee's influence on culture was huge - but let's not overlook his impact on our humanity
Categories: Science and society

Three ways to find your purpose in life and reap the benefits

Genetics - Tue, 2018-11-13 14:00
Having a sense of what you want to do with your life can help you live longer, slash your risk of disease and improve your sex life – and it’s easy to do
Categories: Biology

Three ways to find your purpose in life and reap the benefits

Genetically modified organisms (GMO) - Tue, 2018-11-13 14:00
Having a sense of what you want to do with your life can help you live longer, slash your risk of disease and improve your sex life – and it’s easy to do
Categories: Science and society

Growing demand for oil will lead to shortage and high prices in 2020s

Genetically modified organisms (GMO) - Tue, 2018-11-13 02:01
Even if governments step up action on energy, fossil fuel consumption will keep growing for at least another 20 years according to a major new report
Categories: Science and society

Growing demand for oil will lead to shortage and high prices in 2020s

HIV and AIDS - Tue, 2018-11-13 02:01
Even if governments step up action on energy, fossil fuel consumption will keep growing for at least another 20 years according to a major new report