Feed aggregator

The UK has already had more wildfires in 2019 than any year on record

HIV and AIDS - Tue, 2019-04-23 18:48
Just four months into 2019, the UK has been hit by more large wildfires than in the whole of 2018. Fires are thought to be made more likely by climate change

Battery-free pacemaker harvests energy from pig hearts in first tests

Genetically modified organisms (GMO) - Tue, 2019-04-23 18:00
A battery-free pacemaker that turns heartbeats into electricity has been successfully tested in pigs for the first time
Categories: Science and society

Battery-free pacemaker harvests energy from pig hearts in first tests

Genetics - Tue, 2019-04-23 18:00
A battery-free pacemaker that turns heartbeats into electricity has been successfully tested in pigs for the first time
Categories: Biology

Battery-free pacemaker harvests energy from pig hearts in first tests

HIV and AIDS - Tue, 2019-04-23 18:00
A battery-free pacemaker that turns heartbeats into electricity has been successfully tested in pigs for the first time

SpaceX Crew Dragon capsule lost after 'anomaly' during ground test

Genetically modified organisms (GMO) - Tue, 2019-04-23 14:14
The Crew Dragon capsule is intended to ferry astronauts to the International Space Station, but a possible explosion during a ground test may set launches back
Categories: Science and society

SpaceX Crew Dragon capsule lost after 'anomaly' during ground test

Genetics - Tue, 2019-04-23 14:14
The Crew Dragon capsule is intended to ferry astronauts to the International Space Station, but a possible explosion during a ground test may set launches back
Categories: Biology

SpaceX Crew Dragon capsule lost after 'anomaly' during ground test

HIV and AIDS - Tue, 2019-04-23 14:14
The Crew Dragon capsule is intended to ferry astronauts to the International Space Station, but a possible explosion during a ground test may set launches back

Coal-free spells are good, but the UK is falling short of carbon goals

Genetically modified organisms (GMO) - Tue, 2019-04-23 13:45
Despite growth in renewable energy, the UK still uses plenty of gas – and other sectors are failing to cut emissions
Categories: Science and society

Coal-free spells are good, but the UK is falling short of carbon goals

Genetics - Tue, 2019-04-23 13:45
Despite growth in renewable energy, the UK still uses plenty of gas – and other sectors are failing to cut emissions
Categories: Biology

Coal-free spells are good, but the UK is falling short of carbon goals

HIV and AIDS - Tue, 2019-04-23 13:45
Despite growth in renewable energy, the UK still uses plenty of gas – and other sectors are failing to cut emissions

How does a protein’s structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin

PLOS Biology (new articles) - Mon, 2019-04-22 23:00

by Raquel L. Lieberman

Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in myocilin likely lead to disease, but unlocking myocilin’s biological function is still an elusive goalpost. Is normal myocilin unimportant in the human body? Are scientists using the wrong methods to study myocilin biology? Here, I discuss my scientific journey into understanding one small part of the fascinating organ that is the eye.
Categories: Biology, Journals

Molecular understanding of calcium permeation through the open Orai channel

PLOS Biology (new articles) - Mon, 2019-04-22 23:00

by Xiaofen Liu, Guangyan Wu, Yi Yu, Xiaozhe Chen, Renci Ji, Jing Lu, Xin Li, Xing Zhang, Xue Yang, Yuequan Shen

The Orai channel is characterized by voltage independence, low conductance, and high Ca2+ selectivity and plays an important role in Ca2+ influx through the plasma membrane (PM). How the channel is activated and promotes Ca2+ permeation is not well understood. Here, we report the crystal structure and cryo-electron microscopy (cryo-EM) reconstruction of a Drosophila melanogaster Orai (dOrai) mutant (P288L) channel that is constitutively active according to electrophysiology. The open state of the Orai channel showed a hexameric assembly in which 6 transmembrane 1 (TM1) helices in the center form the ion-conducting pore, and 6 TM4 helices in the periphery form extended long helices. Orai channel activation requires conformational transduction from TM4 to TM1 and eventually causes the basic section of TM1 to twist outward. The wider pore on the cytosolic side aggregates anions to increase the potential gradient across the membrane and thus facilitate Ca2+ permeation. The open-state structure of the Orai channel offers insights into channel assembly, channel activation, and Ca2+ permeation.
Categories: Biology, Journals

Satellites are checking if boats in remote places are fishing legally

Genetically modified organisms (GMO) - Mon, 2019-04-22 11:00
The Indonesian government is using tiny internet-providing satellites to check if boats in the middle of the ocean are fishing legally
Categories: Science and society

Satellites are checking if boats in remote places are fishing legally

Genetics - Mon, 2019-04-22 11:00
The Indonesian government is using tiny internet-providing satellites to check if boats in the middle of the ocean are fishing legally
Categories: Biology

Satellites are checking if boats in remote places are fishing legally

HIV and AIDS - Mon, 2019-04-22 11:00
The Indonesian government is using tiny internet-providing satellites to check if boats in the middle of the ocean are fishing legally

Australia’s dingoes may keep feral cats in check and protect wildlife

Genetically modified organisms (GMO) - Mon, 2019-04-22 10:00
Feral cats have contributed to the extinction of 20 of Australia’s native mammals, but another predator – the dingo – might stop them causing more damage
Categories: Science and society

Australia’s dingoes may keep feral cats in check and protect wildlife

Genetics - Mon, 2019-04-22 10:00
Feral cats have contributed to the extinction of 20 of Australia’s native mammals, but another predator – the dingo – might stop them causing more damage
Categories: Biology

Australia’s dingoes may keep feral cats in check and protect wildlife

HIV and AIDS - Mon, 2019-04-22 10:00
Feral cats have contributed to the extinction of 20 of Australia’s native mammals, but another predator – the dingo – might stop them causing more damage

UK government directs £4.6 million to tackling illegal wildlife trade

Genetically modified organisms (GMO) - Mon, 2019-04-22 02:01
Efforts to disrupt grey parrot trade in Cameroon and reduce demand for turtle products in Nicaragua are among 14 projects to win funding from the UK government
Categories: Science and society

UK government directs £4.6 million to tackling illegal wildlife trade

Genetics - Mon, 2019-04-22 02:01
Efforts to disrupt grey parrot trade in Cameroon and reduce demand for turtle products in Nicaragua are among 14 projects to win funding from the UK government
Categories: Biology