Feed aggregator

Vav1 as a Central Regulator of Invadopodia Assembly

Current Biology - Thu, 2013-12-12 02:00
Gina L. Razidlo, Barbara Schroeder, Jing Chen, Daniel D. Billadeau, Mark A. McNiven. Invadopodia are protrusive structures used by tumor cells for degradation of the extracellular matrix to promote invasion [1]. Invadopodia formation and function are regulated by cytoskeletal-remo....
Categories: Biology, Journals

cis-Regulatory Requirements for Tissue-Specific Programs of the Circadian Clock

Current Biology - Thu, 2013-12-12 02:00
Antonio C.A. Meireles-Filho, Anaïs F. Bardet, J. Omar Yáñez-Cuna, Gerald Stampfel, Alexander Stark. BackgroundBroadly expressed transcriptions factors (TFs) control tissue-specific programs of gene expression through interactions with local TF networks. A prime example is the circadian clock: al....
Categories: Biology, Journals

The Genome of the Foraminiferan Reticulomyxa filosa

Current Biology - Thu, 2013-12-12 02:00
Gernot Glöckner, Norbert Hülsmann, Michael Schleicher, Angelika A. Noegel, Ludwig Eichinger, Christoph Gallinger, Jan Pawlowski, Roberto Sierra, Ursula Euteneuer, Loic Pillet, Ahmed Moustafa, Matthias Platzer, Marco Groth, Karol Szafranski, Manfred Schliwa. BackgroundRhizaria are a major branch of eukaryote evolution with an extensive microfossil record, but only scarce molecular data are available. The rhizarian species Reticulomyxa filosa, b....
Categories: Biology, Journals

Feelings about food: the ventral tegmental area in food reward and emotional eating

Trends in Pharmacological Sciences - Wed, 2013-12-11 02:00
Frank J. Meye, Roger A.H. Adan.
• Overconsumption of palatable food mediated by three partially overlapping systems acting on midbrain dopamine neurons.
• Energy balance hormones act directly and in....
Categories: Biology, Healthcare, Journals

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

Developmental Cell (most read) - Mon, 2013-12-09 02:00
Kathrina L. Marcelo, Tiffany M. Sills, Suleyman Coskun, Hema Vasavada, Supriya Sanglikar, Lauren C. Goldie, Karen K. Hirschi. Delineating the mechanism or mechanisms that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing their derivation from human stem cells....
Categories: Biology, Journals

A Mesodermal Factor, T, Specifies Mouse Germ Cell Fate by Directly Activating Germline Determinants

Developmental Cell (most read) - Mon, 2013-12-09 02:00
Shinya Aramaki, Katsuhiko Hayashi, Kazuki Kurimoto, Hiroshi Ohta, Yukihiro Yabuta, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Yuki Kato, Katsuhiko Shirahige, Mitinori Saitou. Germ cells ensure reproduction and heredity. In mice, primordial germ cells (PGCs), the precursors for spermatozoa and oocytes, are induced in pluripotent epiblast by BMP4 and WNT3, yet the underl....
Categories: Biology, Journals

Location, Location, Location: Macrophage Positioning within Tumors Determines Pro- or Antitumor Activity

Cancer Cell - Mon, 2013-12-09 02:00
Lee B. Rivera, Gabriele Bergers. Macrophages infiltrate hypoxic tumor regions, where they promote angiogenesis and immunosuppression. In this issue of Cancer Cell, Casazza and colleagues report that tumor-associated macrop....
Categories: Biology, Cancer, Journals

RAS and ROS in Rhabdomyosarcoma

Cancer Cell - Mon, 2013-12-09 02:00
Minsi Zhang, Corinne M. Linardic, David G. Kirsch. The 5-year survival for localized rhabdomyosarcoma is over 70%, but only 30% for patients presenting with metastatic disease. In this issue of Cancer Cell, Chen and colleagues performed who....
Categories: Biology, Cancer, Journals

A Novel Bullet Hits the Proteasome

Cancer Cell - Mon, 2013-12-09 02:00
Alexei F. Kisselev. An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessent....
Categories: Biology, Cancer, Journals

The Evolution of Tumor Classification: A Role for Genomics?

Cancer Cell - Mon, 2013-12-09 02:00
Paul A. Bunn, Wilbur Franklin, Robert C. Doebele. Lung cancers are divided into four types according to their histologic appearance. Therapeutic decisions are partly based on histology. A recent study indicates that certain molecular alterations ....
Categories: Biology, Cancer, Journals

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

Cancer Cell - Mon, 2013-12-09 02:00
Andrea Casazza, Damya Laoui, Mathias Wenes, Sabrina Rizzolio, Nicklas Bassani, Marco Mambretti, Sofie Deschoemaeker, Jo A. Van Ginderachter, Luca Tamagnone, Massimiliano Mazzone. Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor progression; however, the underlying guidance mechanisms are unknown. Here, we report that hypoxia-induced Se....
Categories: Biology, Cancer, Journals

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

Cancer Cell - Mon, 2013-12-09 02:00
Xiang Chen, Elizabeth Stewart, Anang A. Shelat, Chunxu Qu, Armita Bahrami, Mark Hatley, Gang Wu, Cori Bradley, Justina McEvoy, Alberto Pappo, Sheri Spunt, Marcus B. Valentine, Virginia Valentine, Fred Krafcik, Walter H. Lang, Monika Wierdl, Lyudmila Tsurkan, Viktor Tolleman, Sara M. Federico, Chris Morton, Charles Lu, Li Ding, John Easton, Michael Rusch, Panduka Nagahawatte, Jianmin Wang, Matthew Parker, Lei Wei, Erin Hedlund, David Finkelstein, Michael Edmonson, Sheila Shurtleff, Kristy Boggs, Heather Mulder, Donald Yergeau, Steve Skapek, Douglas S. Hawkins, Nilsa Ramirez, Philip M. Potter, John A. Sandoval, Andrew M. Davidoff, Elaine R. Mardis, Richard K. Wilson, Jinghui Zhang, James R. Downing, Michael A. Dyer. Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with ....
Categories: Biology, Cancer, Journals

NCOA5 Haploinsufficiency Results in Glucose Intolerance and Subsequent Hepatocellular Carcinoma

Cancer Cell - Mon, 2013-12-09 02:00
Shenglan Gao, Aimin Li, Feiye Liu, Fengsheng Chen, Mark Williams, Chengliang Zhang, Zakiya Kelley, Chin-Lee Wu, Rongcheng Luo, Hua Xiao. Type 2 diabetes (T2D) and male gender are associated with hepatocellular carcinoma (HCC) development. We demonstrate that heterozygous deletion of the Ncoa5 gene causes spontaneous developm....
Categories: Biology, Cancer, Journals

SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer

Cancer Cell - Mon, 2013-12-09 02:00
Lianjie Li, Chuan Shen, Eijiro Nakamura, Kiyohiro Ando, Sabina Signoretti, Rameen Beroukhim, Glenn S. Cowley, Patrick Lizotte, Ella Liberzon, Steven Bair, David E. Root, Pablo Tamayo, Aviad Tsherniak, Su-Chun Cheng, Barbara Tabak, Anders Jacobsen, A. Ari Hakimi, Nikolaus Schultz, Giovanni Ciriello, Chris Sander, James J. Hsieh, William G. Kaelin. Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and is often linked to loss of chromosome 3p, which harbors the VHL tumor suppressor gene, loss of chromosom....
Categories: Biology, Cancer, Journals

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

Cancer Cell - Mon, 2013-12-09 02:00
Ruth Perets, Gregory A. Wyant, Katherine W. Muto, Jonathan G. Bijron, Barish B. Poole, Kenneth T. Chin, Jin Yun H. Chen, Anders W. Ohman, Corey D. Stepule, Soongu Kwak, Alison M. Karst, Michelle S. Hirsch, Sunita R. Setlur, Christopher P. Crum, Daniela M. Dinulescu, Ronny Drapkin. High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site, ....
Categories: Biology, Cancer, Journals

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

Cancer Cell - Mon, 2013-12-09 02:00
Bjoern Chapuy, Michael R. McKeown, Charles Y. Lin, Stefano Monti, Margaretha G.M. Roemer, Jun Qi, Peter B. Rahl, Heather H. Sun, Kelly T. Yeda, John G. Doench, Elaine Reichert, Andrew L. Kung, Scott J. Rodig, Richard A. Young, Margaret A. Shipp, James E. Bradner. Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain (BET) proteins in DLBCL,....
Categories: Biology, Cancer, Journals

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

Cancer Cell - Mon, 2013-12-09 02:00
Ravi K. Anchoori, Balasubramanyam Karanam, Shiwen Peng, Joshua W. Wang, Rosie Jiang, Toshihiko Tanno, Robert Z. Orlowski, William Matsui, Ming Zhao, Michelle A. Rudek, Chien-fu Hung, Xiang Chen, Kylie J. Walters, Richard B.S. Roden. The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of p....
Categories: Biology, Cancer, Journals

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Immunity (most read) - Thu, 2013-12-05 02:00
Muhammad Baghdadi, Akihiro Yoneda, Tsunaki Yamashina, Hiroko Nagao, Yoshihiro Komohara, Shigenori Nagai, Hisaya Akiba, Marc Foretz, Hironori Yoshiyama, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Motohiro Takeya, Benoit Viollet, Hideo Yagita, Masahisa Jinushi. Phagocytosis of apoptotic cells by myeloid cells has been implicated in the maintenance of immune homeostasis. In this study, we found that T cell immunoglobulin- and mucin domain-containing molec....

The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses

Immunity (most read) - Thu, 2013-12-05 02:00
Vasileios Bekiaris, John R. Šedý, Matthew G. Macauley, Antje Rhode-Kurnow, Carl F. Ware. γδ T cells rapidly secrete inflammatory cytokines at barrier sites that aid in protection from pathogens, but mechanisms limiting inflammatory damage remain unclear. We found that retinoid-related....