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RAS and ROS in Rhabdomyosarcoma

Cancer Cell - Mon, 2013-12-09 02:00
Minsi Zhang, Corinne M. Linardic, David G. Kirsch. The 5-year survival for localized rhabdomyosarcoma is over 70%, but only 30% for patients presenting with metastatic disease. In this issue of Cancer Cell, Chen and colleagues performed who....
Categories: Biology, Cancer, Journals

A Novel Bullet Hits the Proteasome

Cancer Cell - Mon, 2013-12-09 02:00
Alexei F. Kisselev. An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessent....
Categories: Biology, Cancer, Journals

The Evolution of Tumor Classification: A Role for Genomics?

Cancer Cell - Mon, 2013-12-09 02:00
Paul A. Bunn, Wilbur Franklin, Robert C. Doebele. Lung cancers are divided into four types according to their histologic appearance. Therapeutic decisions are partly based on histology. A recent study indicates that certain molecular alterations ....
Categories: Biology, Cancer, Journals

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

Cancer Cell - Mon, 2013-12-09 02:00
Andrea Casazza, Damya Laoui, Mathias Wenes, Sabrina Rizzolio, Nicklas Bassani, Marco Mambretti, Sofie Deschoemaeker, Jo A. Van Ginderachter, Luca Tamagnone, Massimiliano Mazzone. Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor progression; however, the underlying guidance mechanisms are unknown. Here, we report that hypoxia-induced Se....
Categories: Biology, Cancer, Journals

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

Cancer Cell - Mon, 2013-12-09 02:00
Xiang Chen, Elizabeth Stewart, Anang A. Shelat, Chunxu Qu, Armita Bahrami, Mark Hatley, Gang Wu, Cori Bradley, Justina McEvoy, Alberto Pappo, Sheri Spunt, Marcus B. Valentine, Virginia Valentine, Fred Krafcik, Walter H. Lang, Monika Wierdl, Lyudmila Tsurkan, Viktor Tolleman, Sara M. Federico, Chris Morton, Charles Lu, Li Ding, John Easton, Michael Rusch, Panduka Nagahawatte, Jianmin Wang, Matthew Parker, Lei Wei, Erin Hedlund, David Finkelstein, Michael Edmonson, Sheila Shurtleff, Kristy Boggs, Heather Mulder, Donald Yergeau, Steve Skapek, Douglas S. Hawkins, Nilsa Ramirez, Philip M. Potter, John A. Sandoval, Andrew M. Davidoff, Elaine R. Mardis, Richard K. Wilson, Jinghui Zhang, James R. Downing, Michael A. Dyer. Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with ....
Categories: Biology, Cancer, Journals

NCOA5 Haploinsufficiency Results in Glucose Intolerance and Subsequent Hepatocellular Carcinoma

Cancer Cell - Mon, 2013-12-09 02:00
Shenglan Gao, Aimin Li, Feiye Liu, Fengsheng Chen, Mark Williams, Chengliang Zhang, Zakiya Kelley, Chin-Lee Wu, Rongcheng Luo, Hua Xiao. Type 2 diabetes (T2D) and male gender are associated with hepatocellular carcinoma (HCC) development. We demonstrate that heterozygous deletion of the Ncoa5 gene causes spontaneous developm....
Categories: Biology, Cancer, Journals

SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer

Cancer Cell - Mon, 2013-12-09 02:00
Lianjie Li, Chuan Shen, Eijiro Nakamura, Kiyohiro Ando, Sabina Signoretti, Rameen Beroukhim, Glenn S. Cowley, Patrick Lizotte, Ella Liberzon, Steven Bair, David E. Root, Pablo Tamayo, Aviad Tsherniak, Su-Chun Cheng, Barbara Tabak, Anders Jacobsen, A. Ari Hakimi, Nikolaus Schultz, Giovanni Ciriello, Chris Sander, James J. Hsieh, William G. Kaelin. Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and is often linked to loss of chromosome 3p, which harbors the VHL tumor suppressor gene, loss of chromosom....
Categories: Biology, Cancer, Journals

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

Cancer Cell - Mon, 2013-12-09 02:00
Ruth Perets, Gregory A. Wyant, Katherine W. Muto, Jonathan G. Bijron, Barish B. Poole, Kenneth T. Chin, Jin Yun H. Chen, Anders W. Ohman, Corey D. Stepule, Soongu Kwak, Alison M. Karst, Michelle S. Hirsch, Sunita R. Setlur, Christopher P. Crum, Daniela M. Dinulescu, Ronny Drapkin. High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site, ....
Categories: Biology, Cancer, Journals

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

Cancer Cell - Mon, 2013-12-09 02:00
Bjoern Chapuy, Michael R. McKeown, Charles Y. Lin, Stefano Monti, Margaretha G.M. Roemer, Jun Qi, Peter B. Rahl, Heather H. Sun, Kelly T. Yeda, John G. Doench, Elaine Reichert, Andrew L. Kung, Scott J. Rodig, Richard A. Young, Margaret A. Shipp, James E. Bradner. Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain (BET) proteins in DLBCL,....
Categories: Biology, Cancer, Journals

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

Cancer Cell - Mon, 2013-12-09 02:00
Ravi K. Anchoori, Balasubramanyam Karanam, Shiwen Peng, Joshua W. Wang, Rosie Jiang, Toshihiko Tanno, Robert Z. Orlowski, William Matsui, Ming Zhao, Michelle A. Rudek, Chien-fu Hung, Xiang Chen, Kylie J. Walters, Richard B.S. Roden. The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of p....
Categories: Biology, Cancer, Journals

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Immunity (most read) - Thu, 2013-12-05 02:00
Muhammad Baghdadi, Akihiro Yoneda, Tsunaki Yamashina, Hiroko Nagao, Yoshihiro Komohara, Shigenori Nagai, Hisaya Akiba, Marc Foretz, Hironori Yoshiyama, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Motohiro Takeya, Benoit Viollet, Hideo Yagita, Masahisa Jinushi. Phagocytosis of apoptotic cells by myeloid cells has been implicated in the maintenance of immune homeostasis. In this study, we found that T cell immunoglobulin- and mucin domain-containing molec....

The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses

Immunity (most read) - Thu, 2013-12-05 02:00
Vasileios Bekiaris, John R. Šedý, Matthew G. Macauley, Antje Rhode-Kurnow, Carl F. Ware. γδ T cells rapidly secrete inflammatory cytokines at barrier sites that aid in protection from pathogens, but mechanisms limiting inflammatory damage remain unclear. We found that retinoid-related....

Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

Molecular Cell (most read) - Thu, 2013-12-05 02:00
Fan Yang, Huafeng Zhang, Yide Mei, Mian Wu. Hypoxia has long been linked to the Warburg effect, yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs are involved in the contribution of hypoxia to the Warburg....

The Plasma Membrane Flattens Out to Fuel Cell-Surface Growth during Drosophila Cellularization

Developmental Cell (most read) - Thu, 2013-12-05 02:00
Lauren Figard, Heng Xu, Hernan G. Garcia, Ido Golding, Anna Marie Sokac. Cell-shape change demands cell-surface growth, but how growth is fueled and choreographed is still debated. Here we use cellularization, the first complete cytokinetic event in Drosophila e....
Categories: Biology, Journals

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Immunity (most read) - Thu, 2013-12-05 02:00
M. Kathryn Liszewski, Martin Kolev, Gaelle Le Friec, Marilyn Leung, Paula G. Bertram, Antonella F. Fara, Marta Subias, Matthew C. Pickering, Christian Drouet, Seppo Meri, T. Petteri Arstila, Pirkka T. Pekkarinen, Margaret Ma, Andrew Cope, Thomas Reinheckel, Santiago Rodriguez de Cordoba, Behdad Afzali, John P. Atkinson, Claudia Kemper. Complement is viewed as a critical serum-operative component of innate immunity, with processing of its key component, C3, into activation fragments C3a and C3b confined to the extracellular space....

FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells

Immunity (most read) - Thu, 2013-12-05 02:00
Dewan Md Sakib Hossain, Abir K. Panda, Argha Manna, Suchismita Mohanty, Pushpak Bhattacharjee, Sankar Bhattacharyya, Taniya Saha, Sreeparna Chakraborty, Rajiv K. Kar, Tanya Das, Subhrangsu Chatterjee, Gaurisankar Sa. FoxP3, a lineage-specification factor, executes its multiple activities mostly through transcriptional regulation of target genes. We identified an interleukin-10 (IL-10)-producing FoxP3+

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

Immunity (most read) - Thu, 2013-12-05 02:00
Kai Yang, Sharad Shrestha, Hu Zeng, Peer W.F. Karmaus, Geoffrey Neale, Peter Vogel, David A. Guertin, Richard F. Lamb, Hongbo Chi. Naive T cells respond to antigen stimulation by exiting from quiescence and initiating clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that ....

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Stem Cell: most read - Thu, 2013-12-05 02:00
Gerald Schwank, Bon-Kyoung Koo, Valentina Sasselli, Johanna F. Dekkers, Inha Heo, Turan Demircan, Nobuo Sasaki, Sander Boymans, Edwin Cuppen, Cornelis K. van der Ent, Edward E.S. Nieuwenhuis, Jeffrey M. Beekman, Hans Clevers. Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypically stable epithelial organoids. Increased cAMP levels induce rapid sw....
Categories: Biology, Journals, Stem Cells

Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9

Stem Cell: most read - Thu, 2013-12-05 02:00
Yuxuan Wu, Dan Liang, Yinghua Wang, Meizhu Bai, Wei Tang, Shiming Bao, Zhiqiang Yan, Dangsheng Li, Jinsong Li. The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of....
Categories: Biology, Journals, Stem Cells