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Salmonella Typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP

Immunity (most read) - Thu, 2013-12-12 02:00
Hae Woong Choi, Rhea Brooking-Dixon, Subham Neupane, Chul-Jin Lee, Edward A. Miao, Herman F. Staats, Soman N. Abraham. The virulence of Salmonella is linked to its invasive capacity and suppression of adaptive immunity. This does not explain, however, the rapid dissemination of the pathogen after it breache....

Michael Neuberger (1953–2013)

Immunity (most read) - Thu, 2013-12-12 02:00
Frederick Alt, Michael Reth.

S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3

Immunity (most read) - Thu, 2013-12-12 02:00
Helia B. Schonthaler, Juan Guinea-Viniegra, Stefanie K. Wculek, Isabel Ruppen, Pilar Ximénez-Embún, Ana Guío-Carrión, Raquel Navarro, Nancy Hogg, Keith Ashman, Erwin F. Wagner. Psoriasis is a common heterogeneous inflammatory skin disease with a complex pathophysiology and limited treatment options. Here we performed proteomic analyses of human psoriatic epidermis and fo....

A Long-Playing CD about the γδ TCR Repertoire

Immunity (most read) - Thu, 2013-12-12 02:00
Adrian Hayday, Pierre Vantourout. In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1+ T cell receptors with CD1d, capping a long trail of e....

Making Sense of HIV Innate Sensing

Immunity (most read) - Thu, 2013-12-12 02:00
Andrea L. Cox, Robert F. Siliciano. Innate sensing of HIV is important in host control and pathogenesis. In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA....

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Alexandre Maréchal, Ju-Mei Li, Xiao Ye Ji, Ching-Shyi Wu, Stephanie A. Yazinski, Hai Dang Nguyen, Shizhou Liu, Amanda E. Jiménez, Jianping Jin, Lee Zou. PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). Although the role for PRP19 in splicing is well characterized, its role in the DDR remains elusive. Thr....

Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Guang-Yuh Chiou, Chian-Shiu Chien, Mong-Lien Wang, Ming-Teh Chen, Yi-Ping Yang, Yung-Luen Yu, Yueh Chien, Yun-Ching Chang, Chiung-Chyi Shen, Chung-Ching Chio, Kai-Hsi Lu, Hsin-I. Ma, Kuan-Hsuan Chen, Dean-Mo Liu, Stephanie A. Miller, Yi-Wei Chen, Pin-I. Huang, Yang-Hsin Shih, Mien-Chie Hung, Shih-Hwa Chiou. Epigenetic regulation plays a critical role in glioblastoma (GBM) tumorigenesis. However, how microRNAs (miRNAs) and cytokines cooperate to regulate GBM tumor progression is still unclear. Here, w....

RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Elias G. Bechara, Endre Sebestyén, Isabella Bernardis, Eduardo Eyras, Juan Valcárcel. RBM5, a regulator of alternative splicing of apoptotic genes, and its highly homologous RBM6 and RBM10 are RNA-binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 ....

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Atsushi Saito, Soshi Kanemoto, Yizhou Zhang, Rie Asada, Kenta Hino, Kazunori Imaizumi. The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane r....

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

Stem Cell: most read - Thu, 2013-12-12 02:00
Ciara Metcalfe, Noelyn M. Kljavin, Ryan Ybarra, Frederic J. de Sauvage. The intestinal epithelium continually self-renews and can rapidly regenerate after damage. Lgr5 marks mitotically active intestinal stem cells (ISCs). Importantly, intestinal homeostasis ca....
Categories: Biology, Journals, Stem Cells

Light-Activated Serotonin for Exploring Its Action in Biological Systems

Chemistry and Biology (most read) - Thu, 2013-12-12 02:00
Adam C. Rea, Laura N. Vandenberg, Rebecca E. Ball, Ashley A. Snouffer, Alicia G. Hudson, Yue Zhu, Duncan E. McLain, Lindsey L. Johnston, James D. Lauderdale, Michael Levin, Timothy M. Dore. Serotonin (5-HT) is a neuromodulator involved in regulating mood, appetite, memory, learning, pain, and establishment of left-right (LR) asymmetry in embryonic development. To explore the role of ....
Categories: Biology, Chemistry, Journals

Long-Chain Acyl-CoA Synthetase 4A Regulates Smad Activity and Dorsoventral Patterning in the Zebrafish Embryo

Developmental Cell (most read) - Thu, 2013-12-12 02:00
Rosa Linda Miyares, Cornelia Stein, Björn Renisch, Jennifer Lynn Anderson, Matthias Hammerschmidt, Steven Arthur Farber. Long-chain polyunsaturated fatty acids (LC-PUFA) and their metabolites are critical players in cell biology and embryonic development. Here we show that long-chain acyl-CoA synthetase 4a (Acsl4a),....
Categories: Biology, Journals

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Immunity (most read) - Thu, 2013-12-12 02:00
Xin Li, Chang Shu, Guanghui Yi, Catherine T. Chaton, Catherine L. Shelton, Jiasheng Diao, Xiaobing Zuo, C. Cheng Kao, Andrew B. Herr, Pingwei Li. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2′,5′ cGAMP, that binds to STING....

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

Stem Cell: most read - Thu, 2013-12-12 02:00
Atsuhiro Taguchi, Yusuke Kaku, Tomoko Ohmori, Sazia Sharmin, Minetaro Ogawa, Hiroshi Sasaki, Ryuichi Nishinakamura. Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental origins of the me....
Categories: Biology, Journals, Stem Cells

Solutions to the Public Goods Dilemma in Bacterial Biofilms

Current Biology - Thu, 2013-12-12 02:00
Knut Drescher, Carey D. Nadell, Howard A. Stone, Ned S. Wingreen, Bonnie L. Bassler. Bacteria frequently live in densely populated surface-bound communities, termed biofilms [1–4]. Biofilm-dwelling cells rely on secretion of extracellular substances to construct their communities ....
Categories: Biology, Journals

Reward Contexts Extend Dopamine Signals to Unrewarded Stimuli

Current Biology - Thu, 2013-12-12 02:00
Shunsuke Kobayashi, Wolfram Schultz. Basic tenets of sensory processing emphasize the importance of accurate identification and discrimination of environmental objects [1]. Although this principle holds also for reward, the crucial a....
Categories: Biology, Journals

An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts

Current Biology - Thu, 2013-12-12 02:00
Seth Rakoff-Nahoum, Michael J. Coyne, Laurie E. Comstock. BackgroundThe human intestine is colonized with trillions of microorganisms important to health and disease. There has been an intensive effort to catalog the species and genetic content of this m....
Categories: Biology, Journals

A Mummified Duck-Billed Dinosaur with a Soft-Tissue Cock’s Comb

Current Biology - Thu, 2013-12-12 02:00
Phil R. Bell, Federico Fanti, Philip J. Currie, Victoria M. Arbour. Among living vertebrates, soft tissues are responsible for labile appendages (combs, wattles, proboscides) that are critical for activities ranging from locomotion to sexual display [1]. However, ....
Categories: Biology, Journals

Common Origin of Insect Trachea and Endocrine Organs from a Segmentally Repeated Precursor

Current Biology - Thu, 2013-12-12 02:00
Carlos Sánchez-Higueras, Sol Sotillos, James Castelli-Gair Hombría. Segmented organisms have serially repeated structures [1] that become specialized in some segments [2]. We show here that the Drosophila corpora allata, prothoracic glands, and trachea have....
Categories: Biology, Journals

Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

Current Biology - Thu, 2013-12-12 02:00
Ji Dai, Daniel I. Brooks, David L. Sheinberg. Optogenetics is a recently developed method in which neurons are genetically modified to express membrane proteins sensitive to light, enabling precisely targeted control of neural activity [1–3].....
Categories: Biology, Journals