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RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Elias G. Bechara, Endre Sebestyén, Isabella Bernardis, Eduardo Eyras, Juan Valcárcel. RBM5, a regulator of alternative splicing of apoptotic genes, and its highly homologous RBM6 and RBM10 are RNA-binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 ....

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Atsushi Saito, Soshi Kanemoto, Yizhou Zhang, Rie Asada, Kenta Hino, Kazunori Imaizumi. The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane r....

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

Stem Cell: most read - Thu, 2013-12-12 02:00
Ciara Metcalfe, Noelyn M. Kljavin, Ryan Ybarra, Frederic J. de Sauvage. The intestinal epithelium continually self-renews and can rapidly regenerate after damage. Lgr5 marks mitotically active intestinal stem cells (ISCs). Importantly, intestinal homeostasis ca....
Categories: Biology, Journals, Stem Cells

Light-Activated Serotonin for Exploring Its Action in Biological Systems

Chemistry and Biology (most read) - Thu, 2013-12-12 02:00
Adam C. Rea, Laura N. Vandenberg, Rebecca E. Ball, Ashley A. Snouffer, Alicia G. Hudson, Yue Zhu, Duncan E. McLain, Lindsey L. Johnston, James D. Lauderdale, Michael Levin, Timothy M. Dore. Serotonin (5-HT) is a neuromodulator involved in regulating mood, appetite, memory, learning, pain, and establishment of left-right (LR) asymmetry in embryonic development. To explore the role of ....
Categories: Biology, Chemistry, Journals

Long-Chain Acyl-CoA Synthetase 4A Regulates Smad Activity and Dorsoventral Patterning in the Zebrafish Embryo

Developmental Cell (most read) - Thu, 2013-12-12 02:00
Rosa Linda Miyares, Cornelia Stein, Björn Renisch, Jennifer Lynn Anderson, Matthias Hammerschmidt, Steven Arthur Farber. Long-chain polyunsaturated fatty acids (LC-PUFA) and their metabolites are critical players in cell biology and embryonic development. Here we show that long-chain acyl-CoA synthetase 4a (Acsl4a),....
Categories: Biology, Journals

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Immunity (most read) - Thu, 2013-12-12 02:00
Xin Li, Chang Shu, Guanghui Yi, Catherine T. Chaton, Catherine L. Shelton, Jiasheng Diao, Xiaobing Zuo, C. Cheng Kao, Andrew B. Herr, Pingwei Li. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2′,5′ cGAMP, that binds to STING....

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

Stem Cell: most read - Thu, 2013-12-12 02:00
Atsuhiro Taguchi, Yusuke Kaku, Tomoko Ohmori, Sazia Sharmin, Minetaro Ogawa, Hiroshi Sasaki, Ryuichi Nishinakamura. Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental origins of the me....
Categories: Biology, Journals, Stem Cells

Solutions to the Public Goods Dilemma in Bacterial Biofilms

Current Biology - Thu, 2013-12-12 02:00
Knut Drescher, Carey D. Nadell, Howard A. Stone, Ned S. Wingreen, Bonnie L. Bassler. Bacteria frequently live in densely populated surface-bound communities, termed biofilms [1–4]. Biofilm-dwelling cells rely on secretion of extracellular substances to construct their communities ....
Categories: Biology, Journals

Reward Contexts Extend Dopamine Signals to Unrewarded Stimuli

Current Biology - Thu, 2013-12-12 02:00
Shunsuke Kobayashi, Wolfram Schultz. Basic tenets of sensory processing emphasize the importance of accurate identification and discrimination of environmental objects [1]. Although this principle holds also for reward, the crucial a....
Categories: Biology, Journals

An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts

Current Biology - Thu, 2013-12-12 02:00
Seth Rakoff-Nahoum, Michael J. Coyne, Laurie E. Comstock. BackgroundThe human intestine is colonized with trillions of microorganisms important to health and disease. There has been an intensive effort to catalog the species and genetic content of this m....
Categories: Biology, Journals

A Mummified Duck-Billed Dinosaur with a Soft-Tissue Cock’s Comb

Current Biology - Thu, 2013-12-12 02:00
Phil R. Bell, Federico Fanti, Philip J. Currie, Victoria M. Arbour. Among living vertebrates, soft tissues are responsible for labile appendages (combs, wattles, proboscides) that are critical for activities ranging from locomotion to sexual display [1]. However, ....
Categories: Biology, Journals

Common Origin of Insect Trachea and Endocrine Organs from a Segmentally Repeated Precursor

Current Biology - Thu, 2013-12-12 02:00
Carlos Sánchez-Higueras, Sol Sotillos, James Castelli-Gair Hombría. Segmented organisms have serially repeated structures [1] that become specialized in some segments [2]. We show here that the Drosophila corpora allata, prothoracic glands, and trachea have....
Categories: Biology, Journals

Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

Current Biology - Thu, 2013-12-12 02:00
Ji Dai, Daniel I. Brooks, David L. Sheinberg. Optogenetics is a recently developed method in which neurons are genetically modified to express membrane proteins sensitive to light, enabling precisely targeted control of neural activity [1–3].....
Categories: Biology, Journals

Vav1 as a Central Regulator of Invadopodia Assembly

Current Biology - Thu, 2013-12-12 02:00
Gina L. Razidlo, Barbara Schroeder, Jing Chen, Daniel D. Billadeau, Mark A. McNiven. Invadopodia are protrusive structures used by tumor cells for degradation of the extracellular matrix to promote invasion [1]. Invadopodia formation and function are regulated by cytoskeletal-remo....
Categories: Biology, Journals

cis-Regulatory Requirements for Tissue-Specific Programs of the Circadian Clock

Current Biology - Thu, 2013-12-12 02:00
Antonio C.A. Meireles-Filho, Anaïs F. Bardet, J. Omar Yáñez-Cuna, Gerald Stampfel, Alexander Stark. BackgroundBroadly expressed transcriptions factors (TFs) control tissue-specific programs of gene expression through interactions with local TF networks. A prime example is the circadian clock: al....
Categories: Biology, Journals

The Genome of the Foraminiferan Reticulomyxa filosa

Current Biology - Thu, 2013-12-12 02:00
Gernot Glöckner, Norbert Hülsmann, Michael Schleicher, Angelika A. Noegel, Ludwig Eichinger, Christoph Gallinger, Jan Pawlowski, Roberto Sierra, Ursula Euteneuer, Loic Pillet, Ahmed Moustafa, Matthias Platzer, Marco Groth, Karol Szafranski, Manfred Schliwa. BackgroundRhizaria are a major branch of eukaryote evolution with an extensive microfossil record, but only scarce molecular data are available. The rhizarian species Reticulomyxa filosa, b....
Categories: Biology, Journals

Feelings about food: the ventral tegmental area in food reward and emotional eating

Trends in Pharmacological Sciences - Wed, 2013-12-11 02:00
Frank J. Meye, Roger A.H. Adan.
• Overconsumption of palatable food mediated by three partially overlapping systems acting on midbrain dopamine neurons.
• Energy balance hormones act directly and in....
Categories: Biology, Healthcare, Journals

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

Developmental Cell (most read) - Mon, 2013-12-09 02:00
Kathrina L. Marcelo, Tiffany M. Sills, Suleyman Coskun, Hema Vasavada, Supriya Sanglikar, Lauren C. Goldie, Karen K. Hirschi. Delineating the mechanism or mechanisms that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing their derivation from human stem cells....
Categories: Biology, Journals

A Mesodermal Factor, T, Specifies Mouse Germ Cell Fate by Directly Activating Germline Determinants

Developmental Cell (most read) - Mon, 2013-12-09 02:00
Shinya Aramaki, Katsuhiko Hayashi, Kazuki Kurimoto, Hiroshi Ohta, Yukihiro Yabuta, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Yuki Kato, Katsuhiko Shirahige, Mitinori Saitou. Germ cells ensure reproduction and heredity. In mice, primordial germ cells (PGCs), the precursors for spermatozoa and oocytes, are induced in pluripotent epiblast by BMP4 and WNT3, yet the underl....
Categories: Biology, Journals

Location, Location, Location: Macrophage Positioning within Tumors Determines Pro- or Antitumor Activity

Cancer Cell - Mon, 2013-12-09 02:00
Lee B. Rivera, Gabriele Bergers. Macrophages infiltrate hypoxic tumor regions, where they promote angiogenesis and immunosuppression. In this issue of Cancer Cell, Casazza and colleagues report that tumor-associated macrop....
Categories: Biology, Cancer, Journals