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Regulation of Transcriptional Bursting by a Naturally Oscillating Signal

Current Biology - Thu, 2014-01-02 02:00
Adam M. Corrigan, Jonathan R. Chubb. Transcription is highly stochastic, occurring in irregular bursts [1–3]. For temporal and spatial precision of gene expression, cells must somehow deal with this noisy behavior. To address how thi....
Categories: Biology, Journals

Regulation of transcription factor activity by interconnected post-translational modifications

Trends in Pharmacological Sciences - Mon, 2013-12-30 02:00
Theresa M. Filtz, Walter K. Vogel, Mark Leid.
• Transcription factors integrate extracellular signals.
• Transcription factor PTMs underlie the signaling mechanism to the nucleus.
• PTMs control every aspect ....
Categories: Biology, Healthcare, Journals

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

Molecular Cell (most read) - Thu, 2013-12-26 02:00
Catherine Chen, Byung Hak Ha, Anastasia F. Thévenin, Hua Jane Lou, Rong Zhang, Kevin Y. Yip, Jeffrey R. Peterson, Mark Gerstein, Philip M. Kim, Panagis Filippakopoulos, Stefan Knapp, Titus J. Boggon, Benjamin E. Turk. Eukaryotic protein kinases are generally classified as being either tyrosine or serine-threonine specific. Though not evident from inspection of their primary sequences, many serine-threonine kina....

Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin

Molecular Cell (most read) - Thu, 2013-12-26 02:00
Syuzo Kaneko, Roberto Bonasio, Ricardo Saldaña-Meyer, Takahaki Yoshida, Jinsook Son, Koichiro Nishino, Akihiro Umezawa, Danny Reinberg. JARID2 is an accessory component of Polycomb repressive complex-2 (PRC2) required for the differentiation of embryonic stem cells (ESCs). A role for JARID2 in the recruitment of PRC2 to tar....

Polycomb Potentiates Meis2 Activation in Midbrain by Mediating Interaction of the Promoter with a Tissue-Specific Enhancer

Developmental Cell (most read) - Thu, 2013-12-26 02:00
Takashi Kondo, Kyoichi Isono, Kaori Kondo, Takaho A. Endo, Shigeyoshi Itohara, Miguel Vidal, Haruhiko Koseki. Polycomb-group (PcG) proteins mediate repression of developmental regulators in a reversible manner, contributing to their spatiotemporally regulated expression. However, it is poorl....
Categories: Biology, Journals

Recruitment Collapse and Population Structure of the European Eel Shaped by Local Ocean Current Dynamics

Current Biology - Thu, 2013-12-26 02:00
Miguel Baltazar-Soares, Arne Biastoch, Chris Harrod, Reinhold Hanel, Lasse Marohn, Enno Prigge, Derek Evans, Kenneth Bodles, Erik Behrens, Claus W. Böning, Christophe Eizaguirre. Worldwide, exploited marine fish stocks are under threat of collapse [1]. Although the drivers behind such collapses are diverse, it is becoming evident that failure to consider evolutionary proce....
Categories: Biology, Journals

Microscopic Aquatic Predators Strongly Affect Infection Dynamics of a Globally Emerged Pathogen

Current Biology - Thu, 2013-12-26 02:00
Dirk S. Schmeller, Mark Blooi, An Martel, Trenton W.J. Garner, Matthew C. Fisher, Frédéric Azemar, Frances C. Clare, Camille Leclerc, Lea Jäger, Michelle Guevara-Nieto, Adeline Loyau, Frank Pasmans. Research on emerging infectious wildlife diseases has placed particular emphasis on host-derived barriers to infection and disease. This focus neglects important extrinsic determinants of the host....
Categories: Biology, Journals

Moving One’s Own Body Part Induces a Motion Aftereffect Anchored to the Body Part

Current Biology - Thu, 2013-12-26 02:00
Kazumichi Matsumiya, Satoshi Shioiri. The question of how our body parts successfully interact with objects in the outside world is a fundamental problem in cognitive science and neuroscience [1, 2]. This problem is closely related to....
Categories: Biology, Journals

Transcription in Pronuclei and One- to Four-Cell Embryos Drives Early Development in a Nematode

Current Biology - Thu, 2013-12-26 02:00
Jianbin Wang, Julianne Garrey, Richard E. Davis. BackgroundA long-standing view of development is that transcription is silenced in the oocyte until early divisions in the embryo. The point at which major transcription is reactivated varies betw....
Categories: Biology, Journals

Strigolactone/MAX2-Induced Degradation of Brassinosteroid Transcriptional Effector BES1 Regulates Shoot Branching

Developmental Cell (most read) - Mon, 2013-12-23 02:00
Yuan Wang, Shiyong Sun, Wenjiao Zhu, Kunpeng Jia, Hongquan Yang, Xuelu Wang. Strigolactones (SLs), a class of the most recently identified terpenoid phytohormones, play essential roles in plant development, specifically in suppressing shoot branching. MAX2, a subunit of an....
Categories: Biology, Journals

Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells

Developmental Cell (most read) - Mon, 2013-12-23 02:00
Keiko Nonomura, Yoshifumi Yamaguchi, Misato Hamachi, Masato Koike, Yasuo Uchiyama, Kenichi Nakazato, Atsushi Mochizuki, Asako Sakaue-Sawano, Atsushi Miyawaki, Hiroki Yoshida, Keisuke Kuida, Masayuki Miura. Apoptotic cells are observed in the early developing brain. Apoptosis deficiency is proposed to cause brain overgrowth, but here we show that brain malformations in apoptosis-deficient mutants are....
Categories: Biology, Journals

Is This Mine? Small RNAs Help to Decide

Developmental Cell (most read) - Mon, 2013-12-23 02:00
Bruno F.M. de Albuquerque, René F. Ketting. Genomes are constantly challenged by invaders, so determining what belongs is crucial. Small RNAs silence alien DNA, but Conine et al. (2013), Seth et al. (2013), and Wedeles et al. (2013) now rep....
Categories: Biology, Journals

Rounding Up Natural Gene Expression Variation during Development

Developmental Cell (most read) - Mon, 2013-12-23 02:00
Sebastian M. Waszak, Bart Deplancke. Molecular insights into the genetic control of development have been mainly derived from single gene mutant studies. Francesconi and Lehner (2013) report now in Nature a genome-wide map of ....
Categories: Biology, Journals

Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation

Developmental Cell (most read) - Mon, 2013-12-23 02:00
Kamaleldin E. Elagib, Jeremy D. Rubinstein, Lorrie L. Delehanty, Valerie S. Ngoh, Peter A. Greer, Shuran Li, Jae K. Lee, Zhe Li, Stuart H. Orkin, Ivailo S. Mihaylov, Adam N. Goldfarb. Megakaryocyte morphogenesis employs a “hypertrophy-like” developmental program that is dependent on P-TEFb kinase activation and cytoskeletal remodeling. P-TEFb activation classically occurs by a ....
Categories: Biology, Journals

Somatic Guidance for the Oocyte

Developmental Cell (most read) - Mon, 2013-12-23 02:00
Robert B. Gilchrist, Dulama Richani. The capacity of oocytes to support embryo development and a healthy pregnancy is dependent on complex and poorly understood interactions with the somatic cells that enclose it during its developme....
Categories: Biology, Journals

Genomic insights into WNT/β-catenin signaling

Trends in Pharmacological Sciences - Sat, 2013-12-21 02:00
Joseph Rosenbluh, Xiaoxing Wang, William C. Hahn.
• Mutations in the WNT/β-catenin pathway occur in many types of human cancers.
• New components of the WNT/β-catenin pathway have been identified.
• β-Catenin for....
Categories: Biology, Healthcare, Journals

Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity

Molecular Cell (most read) - Thu, 2013-12-19 02:00
Partha Pratim Das, Zhen Shao, Semir Beyaz, Eftychia Apostolou, Luca Pinello, Alejandro De Los Angeles, Kassandra O’Brien, Jennifer Marino Atsma, Yuko Fujiwara, Minh Nguyen, Damir Ljuboja, Guoji Guo, Andrew Woo, Guo-Cheng Yuan, Tamer Onder, George Daley, Konrad Hochedlinger, Jonghwan Kim, Stuart H. Orkin. Self-renewal and pluripotency of embryonic stem cells (ESCs) are established by multiple regulatory pathways operating at several levels. The roles of histone demethylases (HDMs) in these programs....

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

Stem Cell: most read - Thu, 2013-12-19 02:00
Ziyuan Guo, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, Gong Chen. Loss of neurons after brain injury and in neurodegenerative disease is often accompanied by reactive gliosis and scarring, which are difficult to reverse with existing treatment approaches. Here, ....
Categories: Biology, Journals, Stem Cells

Genetic Modification and Screening in Rat Using Haploid Embryonic Stem Cells

Stem Cell: most read - Thu, 2013-12-19 02:00
Wei Li, Xin Li, Tianda Li, Ming-Gui Jiang, Haifeng Wan, Guan-Zheng Luo, Chunjing Feng, Xiaolong Cui, Fei Teng, Yan Yuan, Quan Zhou, Qi Gu, Ling Shuai, Jiahao Sha, Yamei Xiao, Liu Wang, Zhonghua Liu, Xiu-Jie Wang, Xiao-Yang Zhao, Qi Zhou. The rat is an important animal model in biomedical research, but practical limitations to genetic manipulation have restricted the application of genetic analysis. Here we report the derivation of....
Categories: Biology, Journals, Stem Cells

Fluorescent Probes for Lipid Rafts: From Model Membranes to Living Cells

Chemistry and Biology (most read) - Thu, 2013-12-19 02:00
Andrey S. Klymchenko, Rémy Kreder. Membrane microdomains (rafts) remain one of the controversial issues in biophysics. Fluorescent molecular probes, which make these lipid nanostructures visible through optical techniques, are one ....
Categories: Biology, Chemistry, Journals