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Insights into the structure of class B GPCRs

Trends in Pharmacological Sciences - Thu, 2013-12-19 02:00
Kaspar Hollenstein, Chris de Graaf, Andrea Bortolato, Ming-Wei Wang, Fiona H. Marshall, Raymond C. Stevens.
• GCGR and CRF1 structures show different features compared to class A GPCRs.
• Class B structures and structure-based drug discovery for peptide hormone G....
Categories: Biology, Healthcare, Journals

Molecularly targeted cancer therapy: some lessons from the past decade

Trends in Pharmacological Sciences - Thu, 2013-12-19 02:00
Min Huang, Aijun Shen, Jian Ding, Meiyu Geng.
• Tumor heterogeneity is the key factor underlying limited response rate to targeted therapy.
• Personalized medicines depend on biomarkers for selecting patients and....
Categories: Biology, Healthcare, Journals

Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma

Cancer Cell - Thu, 2013-12-19 02:00
Jin Hou, Ye Zhou, Yuanyuan Zheng, Jia Fan, Weiping Zhou, Irene O.L. Ng, Huichuan Sun, Lunxiu Qin, Shuangjian Qiu, Joyce M.F. Lee, Chung-Mau Lo, Kwan Man, Yuan Yang, Yun Yang, Yingyun Yang, Qian Zhang, Xuhui Zhu, Nan Li, Zhengxin Wang, Guoshan Ding, Shi-Mei Zhuang, Limin Zheng, Xiaoling Luo, Yuan Xie, Anmin Liang, Zhugang Wang, Ming Zhang, Qiang Xia, Tingbo Liang, Yizhi Yu, Xuetao Cao. In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-α (IFN-α) would be very useful in the clinic. We found that expression of....
Categories: Biology, Cancer, Journals

Computer Use Changes Generalization of Movement Learning

Current Biology - Thu, 2013-12-19 02:00
Kunlin Wei, Xiang Yan, Gaiqing Kong, Cong Yin, Fan Zhang, Qining Wang, Konrad Paul Kording. Over the past few decades, one of the most salient lifestyle changes for us has been the use of computers. For many of us, manual interaction with a computer occupies a large portion of our workin....
Categories: Biology, Journals

The Availability of Research Data Declines Rapidly with Article Age

Current Biology - Thu, 2013-12-19 02:00
Timothy H. Vines, Arianne Y.K. Albert, Rose L. Andrew, Florence Débarre, Dan G. Bock, Michelle T. Franklin, Kimberly J. Gilbert, Jean-Sébastien Moore, Sébastien Renaut, Diana J. Rennison. Policies ensuring that research data are available on public archives are increasingly being implemented at the government [1], funding agency [2–4], and journal [5, 6] level. These policies are p....
Categories: Biology, Journals

Rickettsia Actin-Based Motility Occurs in Distinct Phases Mediated by Different Actin Nucleators

Current Biology - Thu, 2013-12-19 02:00
Shawna C.O. Reed, Rebecca L. Lamason, Viviana I. Risca, Emma Abernathy, Matthew D. Welch. Many intracellular bacterial pathogens undergo actin-based motility to promote cell-cell spread during infection [1]. For each pathogen, motility was assumed to be driven by a single actin polymer....
Categories: Biology, Journals

Autophagy in Oncogenic K-Ras Promotes Basal Extrusion of Epithelial Cells by Degrading S1P

Current Biology - Thu, 2013-12-19 02:00
Gloria Slattum, Yapeng Gu, Roger Sabbadini, Jody Rosenblatt. BackgroundTo maintain a protective barrier, epithelia extrude cells destined to die by contracting a band of actin and myosin. Although extrusion can remove cells triggered to die by apoptotic sti....
Categories: Biology, Journals

KI Motifs of Human Knl1 Enhance Assembly of Comprehensive Spindle Checkpoint Complexes around MELT Repeats

Current Biology - Thu, 2013-12-19 02:00
Veronica Krenn, Katharina Overlack, Ivana Primorac, Suzan van Gerwen, Andrea Musacchio. BackgroundThe KMN network, a ten-subunit protein complex, mediates the interaction of kinetochores with spindle microtubules and recruits spindle assembly checkpoint (SAC) constituents to halt cel....
Categories: Biology, Journals

The Representation of Social Facial Touch in Rat Barrel Cortex

Current Biology - Thu, 2013-12-19 02:00
Evgeny Bobrov, Jason Wolfe, Rajnish P. Rao, Michael Brecht. Controlled presentation of stimuli to anesthetized [1] or awake [2] animals suggested that neurons in sensory cortices respond to elementary features [3, 4], but we know little about neuronal resp....
Categories: Biology, Journals

The Interleukin-1 Family: Back to the Future

Immunity (most read) - Thu, 2013-12-12 02:00
Cecilia Garlanda, Charles A. Dinarello, Alberto Mantovani. Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ)....

Leonard Herzenberg (1931–2013): The Life of FACS

Immunity (most read) - Thu, 2013-12-12 02:00
Richard R. Hardy, Mario Roederer.

Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation

Immunity (most read) - Thu, 2013-12-12 02:00
Mark C. Siracusa, Steven A. Saenz, Elia D. Tait Wojno, Brian S. Kim, Lisa C. Osborne, Carly G. Ziegler, Alain J. Benitez, Kathryn R. Ruymann, Donna L. Farber, Patrick M. Sleiman, Hakon Hakonarson, Antonella Cianferoni, Mei-Lun Wang, Jonathan M. Spergel, Michael R. Comeau, David Artis. Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies lin....

New Twist on an Ancient Innate Immune Pathway

Immunity (most read) - Thu, 2013-12-12 02:00
Stephane Lajoie, Marsha Wills-Karp. Activation of the complement system has long been known to be regulated by a series of steps involving fluid-phase convertases. In this issue of Immunity, Liszewski et al. (2013) report the....

Salmonella Typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP

Immunity (most read) - Thu, 2013-12-12 02:00
Hae Woong Choi, Rhea Brooking-Dixon, Subham Neupane, Chul-Jin Lee, Edward A. Miao, Herman F. Staats, Soman N. Abraham. The virulence of Salmonella is linked to its invasive capacity and suppression of adaptive immunity. This does not explain, however, the rapid dissemination of the pathogen after it breache....

Michael Neuberger (1953–2013)

Immunity (most read) - Thu, 2013-12-12 02:00
Frederick Alt, Michael Reth.

S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3

Immunity (most read) - Thu, 2013-12-12 02:00
Helia B. Schonthaler, Juan Guinea-Viniegra, Stefanie K. Wculek, Isabel Ruppen, Pilar Ximénez-Embún, Ana Guío-Carrión, Raquel Navarro, Nancy Hogg, Keith Ashman, Erwin F. Wagner. Psoriasis is a common heterogeneous inflammatory skin disease with a complex pathophysiology and limited treatment options. Here we performed proteomic analyses of human psoriatic epidermis and fo....

A Long-Playing CD about the γδ TCR Repertoire

Immunity (most read) - Thu, 2013-12-12 02:00
Adrian Hayday, Pierre Vantourout. In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1+ T cell receptors with CD1d, capping a long trail of e....

Making Sense of HIV Innate Sensing

Immunity (most read) - Thu, 2013-12-12 02:00
Andrea L. Cox, Robert F. Siliciano. Innate sensing of HIV is important in host control and pathogenesis. In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA....

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Alexandre Maréchal, Ju-Mei Li, Xiao Ye Ji, Ching-Shyi Wu, Stephanie A. Yazinski, Hai Dang Nguyen, Shizhou Liu, Amanda E. Jiménez, Jianping Jin, Lee Zou. PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). Although the role for PRP19 in splicing is well characterized, its role in the DDR remains elusive. Thr....

Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Guang-Yuh Chiou, Chian-Shiu Chien, Mong-Lien Wang, Ming-Teh Chen, Yi-Ping Yang, Yung-Luen Yu, Yueh Chien, Yun-Ching Chang, Chiung-Chyi Shen, Chung-Ching Chio, Kai-Hsi Lu, Hsin-I. Ma, Kuan-Hsuan Chen, Dean-Mo Liu, Stephanie A. Miller, Yi-Wei Chen, Pin-I. Huang, Yang-Hsin Shih, Mien-Chie Hung, Shih-Hwa Chiou. Epigenetic regulation plays a critical role in glioblastoma (GBM) tumorigenesis. However, how microRNAs (miRNAs) and cytokines cooperate to regulate GBM tumor progression is still unclear. Here, w....