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Entrainment of Brain Oscillations by Transcranial Alternating Current Stimulation

Current Biology - Thu, 2014-01-23 02:00
Randolph F. Helfrich, Till R. Schneider, Stefan Rach, Sina A. Trautmann-Lengsfeld, Andreas K. Engel, Christoph S. Herrmann. Novel methods for neuronal entrainment [1–4] provide the unique opportunity to modulate perceptually relevant brain oscillations [5, 6] in a frequency-specific manner and to study their functional....
Categories: Biology, Journals

Nanog Is Dispensable for the Generation of Induced Pluripotent Stem Cells

Current Biology - Thu, 2014-01-23 02:00
Benjamin A. Schwarz, Ori Bar-Nur, José C.R. Silva, Konrad Hochedlinger. Cellular reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) can be achieved through forced expression of the transcription factors Oct4, Klf4, Sox2, an....
Categories: Biology, Journals

Mechanical and Geometrical Constraints Control Kinesin-Based Microtubule Guidance

Current Biology - Thu, 2014-01-23 02:00
Harinath Doodhi, Eugene A. Katrukha, Lukas C. Kapitein, Anna Akhmanova. Proper organization of microtubule networks depends on microtubule-associated proteins and motors that use different spatial cues to guide microtubule growth [1–3]. For example, it has been propos....
Categories: Biology, Journals

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

Trends in Pharmacological Sciences - Sun, 2014-01-19 02:00
Basil P. Hubbard, David A. Sinclair.
• Sirtuins (SIRT1–7) are NAD+-dependent deacylases that promote homeostasis.
• SIRT1 activation shows promise for the treatment of aging and age-related di....
Categories: Biology, Healthcare, Journals

Therapeutic potential of NaV1.1 activators

Trends in Pharmacological Sciences - Sun, 2014-01-19 02:00
Henrik S. Jensen, Morten Grunnet, Jesper F. Bastlund.
• NaV1.1 is the major sodium current in specific inhibitory interneurons.
• Interneuronal dysfunction is linked to epilepsies, schizophrenia, and AD.
•....
Categories: Biology, Healthcare, Journals

Male-Specific Fruitless Isoforms Target Neurodevelopmental Genes to Specify a Sexually Dimorphic Nervous System

Current Biology - Thu, 2014-01-16 02:00
Megan C. Neville, Tetsuya Nojima, Elizabeth Ashley, Darren J. Parker, John Walker, Tony Southall, Bram Van de Sande, Ana C. Marques, Bettina Fischer, Andrea H. Brand, Steven Russell, Michael G. Ritchie, Stein Aerts, Stephen F. Goodwin. BackgroundIn Drosophila, male courtship behavior is regulated in large part by the gene fruitless (fru). fru encodes a set of putative transcription factors that promot....
Categories: Biology, Journals

The SMC Condensin Complex Is Required for Origin Segregation in Bacillus subtilis

Current Biology - Thu, 2014-01-16 02:00
Xindan Wang, Olive W. Tang, Eammon P. Riley, David Z. Rudner. SMC condensin complexes play a central role in organizing and compacting chromosomes in all domains of life [1, 2]. In the bacterium Bacillus subtilis, cells lacking SMC are viable only dur....
Categories: Biology, Journals

Topography of Head Direction Cells in Medial Entorhinal Cortex

Current Biology - Thu, 2014-01-16 02:00
Lisa M. Giocomo, Tor Stensola, Tora Bonnevie, Tiffany Van Cauter, May-Britt Moser, Edvard I. Moser. BackgroundNeural circuits in the medial entorhinal cortex (MEC) support translation of the external environment to an internal map of space, with grid and head direction neurons providing metrics ....
Categories: Biology, Journals

Regulation of Polyp-to-Jellyfish Transition in Aurelia aurita

Current Biology - Thu, 2014-01-16 02:00
Björn Fuchs, Wei Wang, Simon Graspeuntner, Yizhu Li, Santiago Insua, Eva-Maria Herbst, Philipp Dirksen, Anna-Marei Böhm, Georg Hemmrich, Felix Sommer, Tomislav Domazet-Lošo, Ulrich C. Klostermeier, Friederike Anton-Erxleben, Philip Rosenstiel, Thomas C.G. Bosch, Konstantin Khalturin. BackgroundThe life cycle of scyphozoan cnidarians alternates between sessile asexual polyps and pelagic medusa. Transition from one life form to another is triggered by environmental signals, but ....
Categories: Biology, Journals

Cellular and Behavioral Functions of fruitless Isoforms in Drosophila Courtship

Current Biology - Thu, 2014-01-16 02:00
Anne C. von Philipsborn, Sabrina Jörchel, Laszlo Tirian, Ebru Demir, Tomoko Morita, David L. Stern, Barry J. Dickson. BackgroundMale-specific products of the fruitless (fru) gene control the development and function of neuronal circuits that underlie male-specific behaviors in Drosophila, inc....
Categories: Biology, Journals

Visual Space Is Represented by Nonmatching Topographies of Distinct Mouse Retinal Ganglion Cell Types

Current Biology - Thu, 2014-01-16 02:00
Adam Bleckert, Gregory W. Schwartz, Maxwell H. Turner, Fred Rieke, Rachel O.L. Wong. The distributions of neurons in sensory circuits display ordered spatial patterns arranged to enhance or encode specific regions or features of the external environment. Indeed, visual space is no....
Categories: Biology, Journals

Plume-Tracking Behavior of Flying Drosophila Emerges from a Set of Distinct Sensory-Motor Reflexes

Current Biology - Thu, 2014-01-16 02:00
Floris van Breugel, Michael H. Dickinson. BackgroundFor a fruit fly, locating fermenting fruit where it can feed, find mates, and lay eggs is an essential and difficult task requiring the integration of olfactory and visual cues. Here, we....
Categories: Biology, Journals

Alpha Stimulation of the Human Parietal Cortex Attunes Tactile Perception to External Space

Current Biology - Thu, 2014-01-16 02:00
Manuela Ruzzoli, Salvador Soto-Faraco. An intriguing question in neuroscience concerns how somatosensory events on the skin are represented in the human brain. Since Head and Holmes’ [1] neuropsychological dissociation between localizi....
Categories: Biology, Journals

Interlinked Sister Chromosomes Arise in the Absence of Condensin during Fast Replication in B. subtilis

Current Biology - Thu, 2014-01-16 02:00
Stephan Gruber, Jan-Willem Veening, Juri Bach, Martin Blettinger, Marc Bramkamp, Jeff Errington. Condensin—an SMC-kleisin complex—is essential for efficient segregation of sister chromatids in eukaryotes [1–4]. In Escherichia coli and Bacillus subtilis, deletion of condensin sub....
Categories: Biology, Journals

Current progress in antiviral strategies

Trends in Pharmacological Sciences - Wed, 2014-01-15 02:00
Zhiyong Lou, Yuna Sun, Zihe Rao.
• Antiviral agents function as either viral targets or host factors.
• Virus-targeting antivirals (VTAs) function through a direct (DVTAs) or an indirect (InDVTAs) me....
Categories: Biology, Healthcare, Journals

Janet Davison Rowley (1925–2013)

Cancer Cell - Mon, 2014-01-13 02:00
Kathleen H. Goss, Michelle M. Le Beau.
Categories: Biology, Cancer, Journals

CARMA: CARM1 Methylation of SWI/SNF in Breast Cancer

Cancer Cell - Mon, 2014-01-13 02:00
Xiaofeng Wang, Charles W.M. Roberts. In this issue of Cancer Cell, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methylates BAF155/SMARCC1, a core subunit of the SWI/SNF chromatin re....
Categories: Biology, Cancer, Journals

RAS’s Cloak of Invincibility Slips at Last?

Cancer Cell - Mon, 2014-01-13 02:00
Julian Downward. KRAS is the most frequently activated oncogene in human cancer, but it has, so far, shrugged off all attempts to inhibit its function directly. However, a recent report provides an entirely new ap....
Categories: Biology, Cancer, Journals

Unlocking New Therapeutic Targets and Resistance Mechanisms in Mantle Cell Lymphoma

Cancer Cell - Mon, 2014-01-13 02:00
Dolors Colomer, Elías Campo. Mantle cell lymphoma is an aggressive tumor for which new drugs targeting underlying molecular mechanisms are opening promising avenues. A recent study has elucidated the basis for targeting B cel....
Categories: Biology, Cancer, Journals