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Rickettsia Actin-Based Motility Occurs in Distinct Phases Mediated by Different Actin Nucleators

Current Biology - Thu, 2013-12-19 02:00
Shawna C.O. Reed, Rebecca L. Lamason, Viviana I. Risca, Emma Abernathy, Matthew D. Welch. Many intracellular bacterial pathogens undergo actin-based motility to promote cell-cell spread during infection [1]. For each pathogen, motility was assumed to be driven by a single actin polymer....
Categories: Biology, Journals

Autophagy in Oncogenic K-Ras Promotes Basal Extrusion of Epithelial Cells by Degrading S1P

Current Biology - Thu, 2013-12-19 02:00
Gloria Slattum, Yapeng Gu, Roger Sabbadini, Jody Rosenblatt. BackgroundTo maintain a protective barrier, epithelia extrude cells destined to die by contracting a band of actin and myosin. Although extrusion can remove cells triggered to die by apoptotic sti....
Categories: Biology, Journals

KI Motifs of Human Knl1 Enhance Assembly of Comprehensive Spindle Checkpoint Complexes around MELT Repeats

Current Biology - Thu, 2013-12-19 02:00
Veronica Krenn, Katharina Overlack, Ivana Primorac, Suzan van Gerwen, Andrea Musacchio. BackgroundThe KMN network, a ten-subunit protein complex, mediates the interaction of kinetochores with spindle microtubules and recruits spindle assembly checkpoint (SAC) constituents to halt cel....
Categories: Biology, Journals

The Representation of Social Facial Touch in Rat Barrel Cortex

Current Biology - Thu, 2013-12-19 02:00
Evgeny Bobrov, Jason Wolfe, Rajnish P. Rao, Michael Brecht. Controlled presentation of stimuli to anesthetized [1] or awake [2] animals suggested that neurons in sensory cortices respond to elementary features [3, 4], but we know little about neuronal resp....
Categories: Biology, Journals

The Interleukin-1 Family: Back to the Future

Immunity (most read) - Thu, 2013-12-12 02:00
Cecilia Garlanda, Charles A. Dinarello, Alberto Mantovani. Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ)....

Leonard Herzenberg (1931–2013): The Life of FACS

Immunity (most read) - Thu, 2013-12-12 02:00
Richard R. Hardy, Mario Roederer.

Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation

Immunity (most read) - Thu, 2013-12-12 02:00
Mark C. Siracusa, Steven A. Saenz, Elia D. Tait Wojno, Brian S. Kim, Lisa C. Osborne, Carly G. Ziegler, Alain J. Benitez, Kathryn R. Ruymann, Donna L. Farber, Patrick M. Sleiman, Hakon Hakonarson, Antonella Cianferoni, Mei-Lun Wang, Jonathan M. Spergel, Michael R. Comeau, David Artis. Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies lin....

New Twist on an Ancient Innate Immune Pathway

Immunity (most read) - Thu, 2013-12-12 02:00
Stephane Lajoie, Marsha Wills-Karp. Activation of the complement system has long been known to be regulated by a series of steps involving fluid-phase convertases. In this issue of Immunity, Liszewski et al. (2013) report the....

Salmonella Typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP

Immunity (most read) - Thu, 2013-12-12 02:00
Hae Woong Choi, Rhea Brooking-Dixon, Subham Neupane, Chul-Jin Lee, Edward A. Miao, Herman F. Staats, Soman N. Abraham. The virulence of Salmonella is linked to its invasive capacity and suppression of adaptive immunity. This does not explain, however, the rapid dissemination of the pathogen after it breache....

Michael Neuberger (1953–2013)

Immunity (most read) - Thu, 2013-12-12 02:00
Frederick Alt, Michael Reth.

S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3

Immunity (most read) - Thu, 2013-12-12 02:00
Helia B. Schonthaler, Juan Guinea-Viniegra, Stefanie K. Wculek, Isabel Ruppen, Pilar Ximénez-Embún, Ana Guío-Carrión, Raquel Navarro, Nancy Hogg, Keith Ashman, Erwin F. Wagner. Psoriasis is a common heterogeneous inflammatory skin disease with a complex pathophysiology and limited treatment options. Here we performed proteomic analyses of human psoriatic epidermis and fo....

A Long-Playing CD about the γδ TCR Repertoire

Immunity (most read) - Thu, 2013-12-12 02:00
Adrian Hayday, Pierre Vantourout. In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1+ T cell receptors with CD1d, capping a long trail of e....

Making Sense of HIV Innate Sensing

Immunity (most read) - Thu, 2013-12-12 02:00
Andrea L. Cox, Robert F. Siliciano. Innate sensing of HIV is important in host control and pathogenesis. In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA....

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Alexandre Maréchal, Ju-Mei Li, Xiao Ye Ji, Ching-Shyi Wu, Stephanie A. Yazinski, Hai Dang Nguyen, Shizhou Liu, Amanda E. Jiménez, Jianping Jin, Lee Zou. PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). Although the role for PRP19 in splicing is well characterized, its role in the DDR remains elusive. Thr....

Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Guang-Yuh Chiou, Chian-Shiu Chien, Mong-Lien Wang, Ming-Teh Chen, Yi-Ping Yang, Yung-Luen Yu, Yueh Chien, Yun-Ching Chang, Chiung-Chyi Shen, Chung-Ching Chio, Kai-Hsi Lu, Hsin-I. Ma, Kuan-Hsuan Chen, Dean-Mo Liu, Stephanie A. Miller, Yi-Wei Chen, Pin-I. Huang, Yang-Hsin Shih, Mien-Chie Hung, Shih-Hwa Chiou. Epigenetic regulation plays a critical role in glioblastoma (GBM) tumorigenesis. However, how microRNAs (miRNAs) and cytokines cooperate to regulate GBM tumor progression is still unclear. Here, w....

RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Elias G. Bechara, Endre Sebestyén, Isabella Bernardis, Eduardo Eyras, Juan Valcárcel. RBM5, a regulator of alternative splicing of apoptotic genes, and its highly homologous RBM6 and RBM10 are RNA-binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 ....

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

Molecular Cell (most read) - Thu, 2013-12-12 02:00
Atsushi Saito, Soshi Kanemoto, Yizhou Zhang, Rie Asada, Kenta Hino, Kazunori Imaizumi. The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane r....

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

Stem Cell: most read - Thu, 2013-12-12 02:00
Ciara Metcalfe, Noelyn M. Kljavin, Ryan Ybarra, Frederic J. de Sauvage. The intestinal epithelium continually self-renews and can rapidly regenerate after damage. Lgr5 marks mitotically active intestinal stem cells (ISCs). Importantly, intestinal homeostasis ca....
Categories: Biology, Journals, Stem Cells

Light-Activated Serotonin for Exploring Its Action in Biological Systems

Chemistry and Biology (most read) - Thu, 2013-12-12 02:00
Adam C. Rea, Laura N. Vandenberg, Rebecca E. Ball, Ashley A. Snouffer, Alicia G. Hudson, Yue Zhu, Duncan E. McLain, Lindsey L. Johnston, James D. Lauderdale, Michael Levin, Timothy M. Dore. Serotonin (5-HT) is a neuromodulator involved in regulating mood, appetite, memory, learning, pain, and establishment of left-right (LR) asymmetry in embryonic development. To explore the role of ....
Categories: Biology, Chemistry, Journals

Long-Chain Acyl-CoA Synthetase 4A Regulates Smad Activity and Dorsoventral Patterning in the Zebrafish Embryo

Developmental Cell (most read) - Thu, 2013-12-12 02:00
Rosa Linda Miyares, Cornelia Stein, Björn Renisch, Jennifer Lynn Anderson, Matthias Hammerschmidt, Steven Arthur Farber. Long-chain polyunsaturated fatty acids (LC-PUFA) and their metabolites are critical players in cell biology and embryonic development. Here we show that long-chain acyl-CoA synthetase 4a (Acsl4a),....
Categories: Biology, Journals