Feed aggregator

Visual Space Is Represented by Nonmatching Topographies of Distinct Mouse Retinal Ganglion Cell Types

Current Biology - Thu, 2014-01-16 02:00
Adam Bleckert, Gregory W. Schwartz, Maxwell H. Turner, Fred Rieke, Rachel O.L. Wong. The distributions of neurons in sensory circuits display ordered spatial patterns arranged to enhance or encode specific regions or features of the external environment. Indeed, visual space is no....
Categories: Biology, Journals

Plume-Tracking Behavior of Flying Drosophila Emerges from a Set of Distinct Sensory-Motor Reflexes

Current Biology - Thu, 2014-01-16 02:00
Floris van Breugel, Michael H. Dickinson. BackgroundFor a fruit fly, locating fermenting fruit where it can feed, find mates, and lay eggs is an essential and difficult task requiring the integration of olfactory and visual cues. Here, we....
Categories: Biology, Journals

Alpha Stimulation of the Human Parietal Cortex Attunes Tactile Perception to External Space

Current Biology - Thu, 2014-01-16 02:00
Manuela Ruzzoli, Salvador Soto-Faraco. An intriguing question in neuroscience concerns how somatosensory events on the skin are represented in the human brain. Since Head and Holmes’ [1] neuropsychological dissociation between localizi....
Categories: Biology, Journals

Interlinked Sister Chromosomes Arise in the Absence of Condensin during Fast Replication in B. subtilis

Current Biology - Thu, 2014-01-16 02:00
Stephan Gruber, Jan-Willem Veening, Juri Bach, Martin Blettinger, Marc Bramkamp, Jeff Errington. Condensin—an SMC-kleisin complex—is essential for efficient segregation of sister chromatids in eukaryotes [1–4]. In Escherichia coli and Bacillus subtilis, deletion of condensin sub....
Categories: Biology, Journals

Current progress in antiviral strategies

Trends in Pharmacological Sciences - Wed, 2014-01-15 02:00
Zhiyong Lou, Yuna Sun, Zihe Rao.
• Antiviral agents function as either viral targets or host factors.
• Virus-targeting antivirals (VTAs) function through a direct (DVTAs) or an indirect (InDVTAs) me....
Categories: Biology, Healthcare, Journals

Janet Davison Rowley (1925–2013)

Cancer Cell - Mon, 2014-01-13 02:00
Kathleen H. Goss, Michelle M. Le Beau.
Categories: Biology, Cancer, Journals

CARMA: CARM1 Methylation of SWI/SNF in Breast Cancer

Cancer Cell - Mon, 2014-01-13 02:00
Xiaofeng Wang, Charles W.M. Roberts. In this issue of Cancer Cell, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methylates BAF155/SMARCC1, a core subunit of the SWI/SNF chromatin re....
Categories: Biology, Cancer, Journals

RAS’s Cloak of Invincibility Slips at Last?

Cancer Cell - Mon, 2014-01-13 02:00
Julian Downward. KRAS is the most frequently activated oncogene in human cancer, but it has, so far, shrugged off all attempts to inhibit its function directly. However, a recent report provides an entirely new ap....
Categories: Biology, Cancer, Journals

Unlocking New Therapeutic Targets and Resistance Mechanisms in Mantle Cell Lymphoma

Cancer Cell - Mon, 2014-01-13 02:00
Dolors Colomer, Elías Campo. Mantle cell lymphoma is an aggressive tumor for which new drugs targeting underlying molecular mechanisms are opening promising avenues. A recent study has elucidated the basis for targeting B cel....
Categories: Biology, Cancer, Journals

From Anecdote to Targeted Therapy: The Curious Case of Thalidomide in Multiple Myeloma

Cancer Cell - Mon, 2014-01-13 02:00
Jonathan D. Licht, Jake Shortt, Ricky Johnstone. Thalidomide and related drugs are key drugs for the treatment of multiple myeloma (MM). These agents bind to cereblon, a component of a ubiquitin ligase complex, altering the specificity of the co....
Categories: Biology, Cancer, Journals

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

Cancer Cell - Mon, 2014-01-13 02:00
Lindsay E. Wu, Ana P. Gomes, David A. Sinclair. Why does cancer risk increase as we age? Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations, this question is a matter of ongoing debate. Here,....
Categories: Biology, Cancer, Journals

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

Cancer Cell - Mon, 2014-01-13 02:00
Lu Wang, Zibo Zhao, Mark B. Meyer, Sandeep Saha, Menggang Yu, Ailan Guo, Kari B. Wisinski, Wei Huang, Weibo Cai, J. Wesley Pike, Ming Yuan, Paul Ahlquist, Wei Xu. Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the functions of CARM1....
Categories: Biology, Cancer, Journals

Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses

Cancer Cell - Mon, 2014-01-13 02:00
Xuanming Yang, Xunmin Zhang, May Lynne Fu, Ralph R. Weichselbaum, Thomas F. Gajewski, Yajun Guo, Yang-Xin Fu. Antibodies (Abs) that preferentially target oncogenic receptors have been increasingly used for cancer therapy, but tumors often acquire intrinsic Ab resistance after prolonged and costly treatmen....
Categories: Biology, Cancer, Journals

The Cyclin-like Protein Spy1 Regulates Growth and Division Characteristics of the CD133+ Population in Human Glioma

Cancer Cell - Mon, 2014-01-13 02:00
Dorota Lubanska, Brenna A. Market-Velker, Ana C. deCarvalho, Tom Mikkelsen, Elizabeth Fidalgo da Silva, Lisa A. Porter. The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer....
Categories: Biology, Cancer, Journals

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

Cancer Cell - Mon, 2014-01-13 02:00
Karita Peltonen, Laureen Colis, Hester Liu, Rishi Trivedi, Michael S. Moubarek, Henna M. Moore, Baoyan Bai, Michelle A. Rudek, Charles J. Bieberich, Marikki Laiho. We define the activity and mechanisms of action of a small molecule lead compound for cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60....
Categories: Biology, Cancer, Journals

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

Cancer Cell - Mon, 2014-01-13 02:00
Jens G. Lohr, Petar Stojanov, Scott L. Carter, Peter Cruz-Gordillo, Michael S. Lawrence, Daniel Auclair, Carrie Sougnez, Birgit Knoechel, Joshua Gould, Gordon Saksena, Kristian Cibulskis, Aaron McKenna, Michael A. Chapman, Ravid Straussman, Joan Levy, Louise M. Perkins, Jonathan J. Keats, Steven E. Schumacher, Mara Rosenberg, Gad Getz, Todd R. Golub. We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discove....
Categories: Biology, Cancer, Journals

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption

Cancer Cell - Mon, 2014-01-13 02:00
Chan Kim, Hanseul Yang, Yoko Fukushima, Phei Er Saw, Junyeop Lee, Jin-Sung Park, Intae Park, Jinmyung Jung, Hiroshi Kataoka, Doheon Lee, Won Do Heo, Injune Kim, Sangyong Jon, Ralf H. Adams, Shin-Ichi Nishikawa, Akiyoshi Uemura, Gou Young Koh. Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho GTPase, d....
Categories: Biology, Cancer, Journals

Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity

Cancer Cell - Mon, 2014-01-13 02:00
Jie Li, Ying Xu, Xi-Dai Long, Wei Wang, Hui-Ke Jiao, Zhu Mei, Qian-Qian Yin, Li-Na Ma, Ai-Wu Zhou, Li-Shun Wang, Ming Yao, Qiang Xia, Guo-Qiang Chen. Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of the Cbx family, ....
Categories: Biology, Cancer, Journals

SnapShot: Diffuse Large B Cell Lymphoma

Cancer Cell - Mon, 2014-01-13 02:00
Laura Pasqualucci, Riccardo Dalla-Favera.
Categories: Biology, Cancer, Journals