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A tiny robotic capsule could roam your intestines and suck up mucus

HIV and AIDS - Fri, 2018-09-21 11:00
A small robot could travel through your gut and collect mucus in a vacuum bag to help make diagnosing stomach diseases safer and less painful

Famed mathematician claims proof of 160-year-old Riemann hypothesis

Genetics - Fri, 2018-09-21 10:15
Michael Atiyah, a famed UK mathematician, claims that he has a "simple proof" of the Riemann hypothesis, a key unsolved question about the nature of prime numbers
Categories: Biology

Famed mathematician claims proof of 160-year-old Riemann hypothesis

Genetically modified organisms (GMO) - Fri, 2018-09-21 10:15
Michael Atiyah, a famed UK mathematician, claims that he has a "simple proof" of the Riemann hypothesis, a key unsolved question about the nature of prime numbers
Categories: Science and society

Famed mathematician claims proof of 160-year-old Riemann hypothesis

HIV and AIDS - Fri, 2018-09-21 10:15
Michael Atiyah, a famed UK mathematician, claims that he has a "simple proof" of the Riemann hypothesis, a key unsolved question about the nature of prime numbers

Zapping your guts with electricity can help relieve constipation

Genetics - Fri, 2018-09-21 08:00
Passing a gentle electric current through the abdomen encourages bowel movements in people with chronic constipation, a clinical trial has found
Categories: Biology

Subliminal messages can make you forget memories without realising

Genetics - Fri, 2018-09-21 08:00
Being told not to remember something makes you less likely to remember it in future – and now a study has found this can happen without you even realising it
Categories: Biology

Subliminal messages can make you forget memories without realising

HIV and AIDS - Fri, 2018-09-21 08:00
Being told not to remember something makes you less likely to remember it in future – and now a study has found this can happen without you even realising it

Zapping your guts with electricity can help relieve constipation

HIV and AIDS - Fri, 2018-09-21 08:00
Passing a gentle electric current through the abdomen encourages bowel movements in people with chronic constipation, a clinical trial has found

Zapping your guts with electricity can help relieve constipation

Genetically modified organisms (GMO) - Fri, 2018-09-21 08:00
Passing a gentle electric current through the abdomen encourages bowel movements in people with chronic constipation, a clinical trial has found
Categories: Science and society

Subliminal messages can make you forget memories without realising

Genetically modified organisms (GMO) - Fri, 2018-09-21 08:00
Being told not to remember something makes you less likely to remember it in future – and now a study has found this can happen without you even realising it
Categories: Science and society

Aging alters the epigenetic asymmetry of HSC division

PLOS Biology (new articles) - Thu, 2018-09-20 23:00

by M. Carolina Florian, Markus Klose, Mehmet Sacma, Jelena Jablanovic, Luke Knudson, Kalpana J. Nattamai, Gina Marka, Angelika Vollmer, Karin Soller, Vadim Sakk, Nina Cabezas-Wallscheid, Yi Zheng, Medhanie A. Mulaw, Ingmar Glauche, Hartmut Geiger

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate—using a comprehensive set of paired daughter cell analyses that include single-cell 3D confocal imaging, single-cell transplants, single-cell RNA-seq, and single-cell transposase-accessible chromatin sequencing (ATAC-seq)—that the outcome of HSC divisions is strongly linked to the polarity status before mitosis, which is in turn determined by the level of the activity Cdc42 in stem cells. Aged apolar HSCs undergo preferentially self-renewing symmetric divisions, resulting in daughter stem cells with reduced regenerative capacity and lymphoid potential, while young polar HSCs undergo preferentially asymmetric divisions. Mathematical modeling in combination with experimental data implies a mechanistic role of the asymmetric sorting of Cdc42 in determining the potential of daughter cells via epigenetic mechanisms. Therefore, molecules that control HSC polarity might serve as modulators of the mode of stem cell division regulating the potential of daughter cells.
Categories: Biology, Journals

Earliest known animal was a half-billion-year-old underwater blob

Genetics - Thu, 2018-09-20 20:00
The weird ‘Ediacaran’ fossils have stumped scientists for decades - now fat molecules found inside some of them confirm they are the most ancient animals we know
Categories: Biology

Earliest known animal was a half-billion-year-old underwater blob

HIV and AIDS - Thu, 2018-09-20 20:00
The weird ‘Ediacaran’ fossils have stumped scientists for decades - now fat molecules found inside some of them confirm they are the most ancient animals we know

Earliest known animal was a half-billion-year-old underwater blob

Genetically modified organisms (GMO) - Thu, 2018-09-20 20:00
The weird ‘Ediacaran’ fossils have stumped scientists for decades - now fat molecules found inside some of them confirm they are the most ancient animals we know
Categories: Science and society

Divers are attempting to regrow Great Barrier Reef with electricity

Genetically modified organisms (GMO) - Thu, 2018-09-20 19:00
It may be possible to restore damaged parts of the Great Barrier Reef by electrically stimulating coral fragments grown on underwater metal frames
Categories: Science and society

The mystery of the dinosaur with crocodile jaws, bear claws and a sail

Genetics - Thu, 2018-09-20 17:00
No one knows why dinosaurs never conquered the seas. But giant semi-aquatic predator Spinosaurus is revealing some teasing hints
Categories: Biology

Octopuses taking MDMA get all huggy and loved-up with each other

Genetics - Thu, 2018-09-20 17:00
Octopuses respond to ecstasy in the same way as we do, suggesting the basis for social behaviour evolved more than 500 million years ago
Categories: Biology

Animals can count, but can’t read numbers – and now we know why

Genetics - Thu, 2018-09-20 17:00
Humans but not animals learn that symbols like ‘2’ and ‘4’ represent numbers by recruiting a unique set of neurons to identify them
Categories: Biology

Octopuses taking MDMA get all huggy and loved-up with each other

HIV and AIDS - Thu, 2018-09-20 17:00
Octopuses respond to ecstasy in the same way as we do, suggesting the basis for social behaviour evolved more than 500 million years ago

Animals can count, but can’t read numbers – and now we know why

HIV and AIDS - Thu, 2018-09-20 17:00
Humans but not animals learn that symbols like ‘2’ and ‘4’ represent numbers by recruiting a unique set of neurons to identify them