Chemistry and Biology (most read)

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Chemistry and Biology - Most Read Articles
Updated: 4 years 20 weeks ago

Highly Efficient Self-Replicating RNA Enzymes

Thu, 2014-01-02 02:00
Michael P. Robertson, Gerald F. Joyce. An RNA enzyme has been developed that catalyzes the joining of oligonucleotide substrates to form additional copies of itself, undergoing self-replication with exponential growth. The enzyme also ....
Categories: Biology, Chemistry, Journals

Fluorescent Probes for Lipid Rafts: From Model Membranes to Living Cells

Thu, 2013-12-19 02:00
Andrey S. Klymchenko, Rémy Kreder. Membrane microdomains (rafts) remain one of the controversial issues in biophysics. Fluorescent molecular probes, which make these lipid nanostructures visible through optical techniques, are one ....
Categories: Biology, Chemistry, Journals

Structure and Function of Phosphonoacetaldehyde Dehydrogenase: The Missing Link in Phosphonoacetate Formation

Thu, 2013-12-19 02:00
Vinayak Agarwal, Spencer C. Peck, Jui-Hui Chen, Svetlana A. Borisova, Jonathan R. Chekan, Wilfred A. van der Donk, Satish K. Nair. Phosphonates (C-PO32−) have applications as antibiotics, herbicides, and detergents. In some environments, these molecules represent the predominant source of phosphorus, and....
Categories: Biology, Chemistry, Journals

Old Molecules, New Biochemistry

Thu, 2013-12-19 02:00
Susanne Fetzner, Steffen L. Drees. The study by Dulcey and colleagues in this issue of Chemistry & Biology changes our perception of the pathway of 2-alkyl-4-hydroxyquinoline biosynthesis by the opportunistic pathogen
Categories: Biology, Chemistry, Journals

Cyclolization of D-Lysergic Acid Alkaloid Peptides

Thu, 2013-12-19 02:00
Judith Havemann, Dominik Vogel, Bernhard Loll, Ullrich Keller. The tripeptide chains of the ergopeptines, a class of pharmacologically important D-lysergic acid alkaloid peptides, are arranged in a unique bicyclic cyclol based on an amino-terminal α-hydroxyam....
Categories: Biology, Chemistry, Journals

Light-Activated Serotonin for Exploring Its Action in Biological Systems

Thu, 2013-12-12 02:00
Adam C. Rea, Laura N. Vandenberg, Rebecca E. Ball, Ashley A. Snouffer, Alicia G. Hudson, Yue Zhu, Duncan E. McLain, Lindsey L. Johnston, James D. Lauderdale, Michael Levin, Timothy M. Dore. Serotonin (5-HT) is a neuromodulator involved in regulating mood, appetite, memory, learning, pain, and establishment of left-right (LR) asymmetry in embryonic development. To explore the role of ....
Categories: Biology, Chemistry, Journals

Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell’s Chemical Legoland

Thu, 2013-12-05 02:00
Mark Helm, Juan D. Alfonzo. Nature combines existing biochemical building blocks, at times with subtlety of purpose. RNA modifications are a prime example of this, where standard RNA nucleosides are decorated with chemical g....
Categories: Biology, Chemistry, Journals

Exploring Intermolecular Interactions of a Substrate Binding Protein Using a Riboswitch-Based Sensor

Wed, 2013-11-27 02:00
Casey C. Fowler, Seiji Sugiman-Marangos, Murray S. Junop, Eric D. Brown, Yingfu Li. The study of biological transporters can be hampered by a dearth of methodology for tracking their activity within cells. Here, we present a means of monitoring the function of transport machinery....
Categories: Biology, Chemistry, Journals

Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes

Wed, 2013-11-27 02:00
Joanna F. McGouran, Selina R. Gaertner, Mikael Altun, Holger B. Kramer, Benedikt M. Kessler. Posttranslational modification with ubiquitin (Ub) controls many cellular processes, and aberrant ubiquitination can contribute to cancer, immunopathology, and neurodegeneration. The versatility a....
Categories: Biology, Chemistry, Journals

A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening

Wed, 2013-11-27 02:00
Yuan Yuan, Kate Hartland, Zarko Boskovic, Yikai Wang, Deepika Walpita, Philippe A. Lysy, Cheng Zhong, Damian W. Young, Young-kwon Kim, Nicola J. Tolliday, Etienne M. Sokal, Stuart L. Schreiber, Bridget K. Wagner. Pancreatic and duodenal homeobox 1 (PDX1), a member of the homeodomain-containing transcription factor family, is a key transcription factor important for both pancreas development and mature β ce....
Categories: Biology, Chemistry, Journals

Proofreading of Noncognate Acyl Adenylates by an Acyl-Coenzyme A Ligase

Thu, 2013-11-21 02:00
Miglena Manandhar, John E. Cronan. Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pretransfer editing by pimeloyl-coenzyme A (CoA) liga....
Categories: Biology, Chemistry, Journals

Core Assembly Mechanism of Quinocarcin/SF-1739: Bimodular Complex Nonribosomal Peptide Synthetases for Sequential Mannich-type Reactions

Thu, 2013-11-21 02:00
Tomoshige Hiratsuka, Kento Koketsu, Atsushi Minami, Shunsuke Kaneko, Chiaki Yamazaki, Kenji Watanabe, Hiroki Oguri, Hideaki Oikawa. Quinocarcin and SF-1739, potent antitumor antibiotics, share a common tetracyclic tetrahydroisoquinoline (THIQ)-pyrrolidine core scaffold. Herein, we describe the identification of their biosynthe....
Categories: Biology, Chemistry, Journals

Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources

Thu, 2013-11-21 02:00
Yan-Ling Wu, Ganesh N. Pandian, Yan-Ping Ding, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama. Adult mammals possess limited ability to regenerate their lost tissues or organs. The epoch-making strategy of inducing pluripotency in somatic cells incorporates multiple applications in regenera....
Categories: Biology, Chemistry, Journals

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

Thu, 2013-11-21 02:00
Jason E. Hudak, Carolyn R. Bertozzi. The beginning of the 20th century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focus....
Categories: Biology, Chemistry, Journals

NAD as a Genotype-Specific Drug Target

Thu, 2013-11-21 02:00
Szu-Chieh Mei, Charles Brenner. Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltra....
Categories: Biology, Chemistry, Journals

Two Birds with One Stone: Dual p110δ and p110γ Inhibition

Thu, 2013-11-21 02:00
Klaus Okkenhaug. In this issue of Chemistry & Biology, Winkler and colleagues describe the discovery and preclinical development of IPI-145, a new inhibitor of the phosphoinositide 3-kinase (PI3K) isofo....
Categories: Biology, Chemistry, Journals

Catalytic Mechanism of Stereospecific Formation of cis-Configured Prenylated Pyrroloindoline Diketopiperazines by Indole Prenyltransferases

Thu, 2013-11-14 02:00
Xia Yu, Georg Zocher, Xiulan Xie, Mike Liebhold, Stefan Schütz, Thilo Stehle, Shu-Ming Li. Indole prenyltransferases AnaPT, CdpC3PT, and CdpNPT are known to catalyze the formation of prenylated pyrroloindoline diketopiperazines from tryptophan-containing cyclic dipeptides in one-step re....
Categories: Biology, Chemistry, Journals

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

Thu, 2013-11-14 02:00
Anna Rodina, Pallav D. Patel, Yanlong Kang, Yogita Patel, Imad Baaklini, Michael J.H. Wong, Tony Taldone, Pengrong Yan, Chenghua Yang, Ronnie Maharaj, Alexander Gozman, Maulik R. Patel, Hardik J. Patel, William Chirico, Hediye Erdjument-Bromage, Tanaji T. Talele, Jason C. Young, Gabriela Chiosis. Hsp70s are important cancer chaperones that act upstream of Hsp90 and exhibit independent anti-apoptotic activities. To develop chemical tools for the study of human Hsp70, we developed a homology....
Categories: Biology, Chemistry, Journals

Open Questions in Lipid Droplet Biology

Thu, 2013-11-14 02:00
Yuki Ohsaki, Michitaka Suzuki, Toyoshi Fujimoto. Lipid droplets (LDs) have been the focus of intense research for the past decade because of their active engagement in lipid metabolism and relationship with diseases. In contrast to other intrace....
Categories: Biology, Chemistry, Journals

The End of an Old Hypothesis: The Pseudomonas Signaling Molecules 4-Hydroxy-2-Alkylquinolines Derive from Fatty Acids, Not 3-Ketofatty Acids

Thu, 2013-11-14 02:00
Carlos Eduardo Dulcey, Valérie Dekimpe, David-Alexandre Fauvelle, Sylvain Milot, Marie-Christine Groleau, Nicolas Doucet, Laurence G. Rahme, François Lépine, Eric Déziel. Groups of pathogenic bacteria use diffusible signals to regulate their virulence in a concerted manner. Pseudomonas aeruginosa uses 4-hydroxy-2-alkylquinolines (HAQs), including 4-hydroxy-2....
Categories: Biology, Chemistry, Journals