Immunity (most read)

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Immunity - Most Read Articles
Updated: 4 years 12 weeks ago

The Interleukin-1 Family: Back to the Future

Thu, 2013-12-12 02:00
Cecilia Garlanda, Charles A. Dinarello, Alberto Mantovani. Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ)....

Leonard Herzenberg (1931–2013): The Life of FACS

Thu, 2013-12-12 02:00
Richard R. Hardy, Mario Roederer.

Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation

Thu, 2013-12-12 02:00
Mark C. Siracusa, Steven A. Saenz, Elia D. Tait Wojno, Brian S. Kim, Lisa C. Osborne, Carly G. Ziegler, Alain J. Benitez, Kathryn R. Ruymann, Donna L. Farber, Patrick M. Sleiman, Hakon Hakonarson, Antonella Cianferoni, Mei-Lun Wang, Jonathan M. Spergel, Michael R. Comeau, David Artis. Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies lin....

New Twist on an Ancient Innate Immune Pathway

Thu, 2013-12-12 02:00
Stephane Lajoie, Marsha Wills-Karp. Activation of the complement system has long been known to be regulated by a series of steps involving fluid-phase convertases. In this issue of Immunity, Liszewski et al. (2013) report the....

Salmonella Typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP

Thu, 2013-12-12 02:00
Hae Woong Choi, Rhea Brooking-Dixon, Subham Neupane, Chul-Jin Lee, Edward A. Miao, Herman F. Staats, Soman N. Abraham. The virulence of Salmonella is linked to its invasive capacity and suppression of adaptive immunity. This does not explain, however, the rapid dissemination of the pathogen after it breache....

Michael Neuberger (1953–2013)

Thu, 2013-12-12 02:00
Frederick Alt, Michael Reth.

S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3

Thu, 2013-12-12 02:00
Helia B. Schonthaler, Juan Guinea-Viniegra, Stefanie K. Wculek, Isabel Ruppen, Pilar Ximénez-Embún, Ana Guío-Carrión, Raquel Navarro, Nancy Hogg, Keith Ashman, Erwin F. Wagner. Psoriasis is a common heterogeneous inflammatory skin disease with a complex pathophysiology and limited treatment options. Here we performed proteomic analyses of human psoriatic epidermis and fo....

A Long-Playing CD about the γδ TCR Repertoire

Thu, 2013-12-12 02:00
Adrian Hayday, Pierre Vantourout. In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1+ T cell receptors with CD1d, capping a long trail of e....

Making Sense of HIV Innate Sensing

Thu, 2013-12-12 02:00
Andrea L. Cox, Robert F. Siliciano. Innate sensing of HIV is important in host control and pathogenesis. In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA....

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Thu, 2013-12-12 02:00
Xin Li, Chang Shu, Guanghui Yi, Catherine T. Chaton, Catherine L. Shelton, Jiasheng Diao, Xiaobing Zuo, C. Cheng Kao, Andrew B. Herr, Pingwei Li. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2′,5′ cGAMP, that binds to STING....

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Thu, 2013-12-05 02:00
Muhammad Baghdadi, Akihiro Yoneda, Tsunaki Yamashina, Hiroko Nagao, Yoshihiro Komohara, Shigenori Nagai, Hisaya Akiba, Marc Foretz, Hironori Yoshiyama, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Motohiro Takeya, Benoit Viollet, Hideo Yagita, Masahisa Jinushi. Phagocytosis of apoptotic cells by myeloid cells has been implicated in the maintenance of immune homeostasis. In this study, we found that T cell immunoglobulin- and mucin domain-containing molec....

The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses

Thu, 2013-12-05 02:00
Vasileios Bekiaris, John R. Šedý, Matthew G. Macauley, Antje Rhode-Kurnow, Carl F. Ware. γδ T cells rapidly secrete inflammatory cytokines at barrier sites that aid in protection from pathogens, but mechanisms limiting inflammatory damage remain unclear. We found that retinoid-related....

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Thu, 2013-12-05 02:00
M. Kathryn Liszewski, Martin Kolev, Gaelle Le Friec, Marilyn Leung, Paula G. Bertram, Antonella F. Fara, Marta Subias, Matthew C. Pickering, Christian Drouet, Seppo Meri, T. Petteri Arstila, Pirkka T. Pekkarinen, Margaret Ma, Andrew Cope, Thomas Reinheckel, Santiago Rodriguez de Cordoba, Behdad Afzali, John P. Atkinson, Claudia Kemper. Complement is viewed as a critical serum-operative component of innate immunity, with processing of its key component, C3, into activation fragments C3a and C3b confined to the extracellular space....

FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells

Thu, 2013-12-05 02:00
Dewan Md Sakib Hossain, Abir K. Panda, Argha Manna, Suchismita Mohanty, Pushpak Bhattacharjee, Sankar Bhattacharyya, Taniya Saha, Sreeparna Chakraborty, Rajiv K. Kar, Tanya Das, Subhrangsu Chatterjee, Gaurisankar Sa. FoxP3, a lineage-specification factor, executes its multiple activities mostly through transcriptional regulation of target genes. We identified an interleukin-10 (IL-10)-producing FoxP3+

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

Thu, 2013-12-05 02:00
Kai Yang, Sharad Shrestha, Hu Zeng, Peer W.F. Karmaus, Geoffrey Neale, Peter Vogel, David A. Guertin, Richard F. Lamb, Hongbo Chi. Naive T cells respond to antigen stimulation by exiting from quiescence and initiating clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that ....

Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer

Wed, 2013-11-27 02:00
Kristi Baker, Timo Rath, Magdalena B. Flak, Janelle C. Arthur, Zhangguo Chen, Jonathan N. Glickman, Inti Zlobec, Eva Karamitopoulou, Matthew D. Stachler, Robert D. Odze, Wayne I. Lencer, Christian Jobin, Richard S. Blumberg. Cancers arising in mucosal tissues account for a disproportionately large fraction of malignancies. Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in....

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

Thu, 2013-11-21 02:00
Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Cécile Conrad, Ilse Hurbain, Ahmed El Marjou, Christine Lacabaratz, Jean-Daniel Lelièvre, Nicolas Manel. HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology. Although both viruses replicate in the T cells of infected patients, only HI....

The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells

Thu, 2013-11-14 02:00
Damon J. Tumes, Atsushi Onodera, Akane Suzuki, Kenta Shinoda, Yusuke Endo, Chiaki Iwamura, Hiroyuki Hosokawa, Haruhiko Koseki, Koji Tokoyoda, Yutaka Suzuki, Shinichiro Motohashi, Toshinori Nakayama. After antigen encounter by CD4+ T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2....

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

Thu, 2013-11-14 02:00
Samantha L. Bailey-Bucktrout, Marc Martinez-Llordella, Xuyu Zhou, Bryan Anthony, Wendy Rosenthal, Herve Luche, Hans J. Fehling, Jeffrey A. Bluestone. Stable Foxp3 expression is crucial for regulatory T (Treg) cell function. We observed that antigen-driven activation and inflammation in the CNS promoted Foxp3 instability selectively in the autor....

The Spleen in Local and Systemic Regulation of Immunity

Thu, 2013-11-14 02:00
Vincenzo Bronte, Mikael J. Pittet. The spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ for iron metabolism and erythrocyte homeostasis. Also, immune and hematopoietic functions have been rec....