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- GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base
- Integrative platform to translate gene sets to networks
- ABC-SysBio--approximate Bayesian computation in Python with GPU support
- Ab initio gene identification in metagenomic sequences
- High accuracy operon prediction method based on STRING database scores
- Binary particle swarm optimization for operon prediction
- FuncBase : a resource for quantitative gene function annotation
- The Newick utilities: high-throughput phylogenetic tree processing in the UNIX shell
- Predicting post-translational lysine acetylation using support vector machines
- Interactive software tool to comprehend the calculation of optimal sequence alignments with dynamic programming
Nucleic Acids Research
- Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples
- Site-specific labeling of Saccharomyces cerevisiae ribosomes for single-molecule manipulations
- Combination of RNA interference and U1 inhibition leads to increased inhibition of gene expression
- Titration-free massively parallel pyrosequencing using trace amounts of starting material
- A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens
Bioinformatics
- Structure-based variable selection for survival data
- SVDetect: a tool to identify genomic structural variations from paired-end and mate-pair sequencing data
- Cassis: detection of genomic rearrangement breakpoints
- Parallelization of the MAFFT multiple sequence alignment program
- An alignment algorithm for bisulfite sequencing using the Applied Biosystems SOLiD System
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HIV and AIDS
- Galapagos: off the danger list, still in danger 9 hours 9 min old
- Reptilians were the earliest North American pioneers 9 hours 52 min old
- Are cloned steak and milk on European menus? 10 hours 46 min old
- Dog brains rotated by selective breeding 10 hours 48 min old
- Graphene bubbles mimic explosive magnetic field 11 hours 7 min old
- Team-working robots huddle together to boost comms 11 hours 38 min old
- Cosmic Trojans may sneak comets towards Earth 14 hours 13 min old
- US food waste worth more than offshore drilling 15 hours 19 min old
- Regulation could save genome scanning, not kill it 1 day 3 hours old
- E. coli engineered to make convenient 'drop-in' biofuel 1 day 6 hours old
- Today on New Scientist: 29 July 2010 1 day 7 hours old
- Galapagos off the Danger List – but why? 1 day 9 hours old
- Satellite quantum communication circles closer 1 day 10 hours old
- Phytoplankton in decline: bye bye food chain? 1 day 11 hours old
- Inside TRAK: a new robot shows us how we think 1 day 11 hours old
Molecular Cell (most read)
- Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia 20 hours 19 min old
- Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration 20 hours 19 min old
- A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair 20 hours 19 min old
- MicroRNA Biogenesis via Splicing and Exosome-Mediated Trimming in Drosophila 20 hours 19 min old
- Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α 20 hours 19 min old
- Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases 20 hours 19 min old
- Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing 20 hours 19 min old
- How Many Ways Are There to Generate Small RNAs? 20 hours 19 min old
- A Consensus of Core Protein Complex Compositions for Saccharomyces cerevisiae 20 hours 19 min old
- What the Mitochondria See 20 hours 19 min old
- Dephosphorylation of F-BAR Protein Cdc15 Modulates Its Conformation and Stimulates Its Scaffolding Activity at the Cell Division Site 20 hours 19 min old
- Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface 20 hours 19 min old
- How To Choose a Good Scientific Problem 20 hours 19 min old
- Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes 20 hours 19 min old
- The Diversity of Ubiquitin Recognition: Hot Spots and Varied Specificity 20 hours 19 min old
Immunity (most read)
- Intrinsic Properties of immunoglobulin IgG1 Isotype-Switched B Cell Receptors Promote Microclustering and the Initiation of Signaling 20 hours 19 min old
- T Helper Cell Differentiation: Understanding the Needs of Hierarchy 20 hours 19 min old
- Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones 20 hours 19 min old
- Interleukin-1β Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue 20 hours 19 min old
- K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling 20 hours 19 min old
- Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming 20 hours 19 min old
- CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection 20 hours 19 min old
- Maintaining Cell Identity through Global Control of Genomic Organization 20 hours 19 min old
- Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor 20 hours 19 min old
- Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge 20 hours 19 min old
- Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation 20 hours 19 min old
- Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways 20 hours 19 min old
- MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1 20 hours 19 min old
- The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut 20 hours 19 min old
- Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation 20 hours 19 min old
Developmental Cell (most read)
- The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells 20 hours 19 min old
- Cancer Dissemination—Lessons from Leukocytes 20 hours 19 min old
- Gradients of a Ubiquitin E3 Ligase Inhibitor and a Caspase Inhibitor Determine Differentiation or Death in Spermatids 20 hours 19 min old
- The GATA Factor HANABA TARANU Is Required to Position the Proembryo Boundary in the Early Arabidopsis Embryo 20 hours 19 min old
- Neogenin Regulation of BMP-Induced Canonical Smad Signaling and Endochondral Bone Formation 20 hours 19 min old
- Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry 20 hours 19 min old
- Epicardial Spindle Orientation Controls Cell Entry into the Myocardium 20 hours 19 min old
- Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes 20 hours 19 min old
- The Autophagy Connection 20 hours 19 min old
- The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling 20 hours 19 min old
- A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions 20 hours 19 min old
- Tumors as Organs: Complex Tissues that Interface with the Entire Organism 20 hours 19 min old
- A Simple Method for Gene Expression and Chromatin Profiling of Individual Cell Types within a Tissue 20 hours 19 min old
- The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals 20 hours 19 min old
- Transcriptome Analysis of Early Organogenesis in Human Embryos 20 hours 19 min old
Current Biology
- Visual Sensitivity Underlying Changes in Visual Consciousness 20 hours 49 min old
- Strong and Consistent Social Bonds Enhance the Longevity of Female Baboons 20 hours 49 min old
- Fitness-Associated Sexual Reproduction in a Filamentous Fungus 20 hours 49 min old
- Olfaction Modulates Visual Perception in Binocular Rivalry 20 hours 49 min old
- An Olfactory Subsystem that Detects Carbon Disulfide and Mediates Food-Related Social Learning 20 hours 49 min old
- Others’ Actions Reduce Crossmodal Integration in Peripersonal Space 20 hours 49 min old
- Walking Modulates Speed Sensitivity in Drosophila Motion Vision 20 hours 49 min old
- Visceral-Locomotory Pistoning in Crawling Caterpillars 20 hours 49 min old
- ASPP2 Regulates Epithelial Cell Polarity through the PAR Complex 20 hours 49 min old
- Sli15INCENP Dephosphorylation Prevents Mitotic Checkpoint Reengagement Due to Loss of Tension at Anaphase Onset 20 hours 49 min old
- Relocation of the Chromosomal Passenger Complex Prevents Mitotic Checkpoint Engagement at Anaphase 20 hours 49 min old
- Path Integration Provides a Scaffold for Landmark Learning in Desert Ants 20 hours 49 min old
- Shedding of the Mucin-Like Flocculin Flo11p Reveals a New Aspect of Fungal Adhesion Regulation 20 hours 49 min old
- The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories 20 hours 49 min old
- DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages 20 hours 49 min old
Genetics
- Regulation could save genome scanning, not kill it 1 day 3 hours old
- Single gene could be key to a baby's first breath 1 week 10 hours old
- Chilled genes are hot hope for new vaccines 2 weeks 4 days old
- Gene switches sexual desires of female mice 3 weeks 12 hours old
- Debate over gender disorder drug 3 weeks 1 day old
- Can a gene test tell you whether you'll live to 100? 3 weeks 1 day old
- Solid-state systems could sequence a genome for $100 3 weeks 2 days old
- If you've got great genes, it pays to be extrovert 3 weeks 4 days old
- DNA tests to reveal ancestral villages 3 weeks 6 days old
- Tibetans adapted to high life at record-breaking rate 4 weeks 1 day old
- Plant nurseries in clover after finding four-leaf gene 4 weeks 1 day old
- Evolvability: How to cash in on the genetic lottery 4 weeks 1 day old
- Zoo plans to bring rare animals back from the dead 4 weeks 2 days old
- Tutankhamen 'killed by sickle-cell disease' 5 weeks 6 hours old
- Genome at 10: The hunt for the 'dark matter' 5 weeks 17 hours old
Chemistry and Biology (most read)
- Protein Chemical Modification on Endogenous Amino Acids 1 day 20 hours old
- Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms 1 day 20 hours old
- Synthetic Strategies for Studying Embryonic Development 1 day 20 hours old
- Probing Translation with Small-Molecule Inhibitors 1 day 20 hours old
- In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent 1 day 20 hours old
- Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology 1 day 20 hours old
- Chemical Genomic Approaches to Study Model Microbes 1 day 20 hours old
- Special Issue ITI 1 day 20 hours old
- Bridging the Gaps between Synapses, Circuits, and Behavior 1 day 20 hours old
- Five Molecules We Would Take to a Remote Island 1 day 20 hours old
- Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine 1 day 20 hours old
- Chemical Proteomics Identifies Nampt as the Target of CB30865, An Orphan Cytotoxic Compound 1 day 20 hours old
- The NIH Molecular Libraries Program: Identifying Chemical Probes for New Medicines 1 day 20 hours old
- Quantitative Cell-Based Reporter Gene Assays Using Droplet-Based Microfluidics 1 day 20 hours old
- Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition 1 day 20 hours old
Stem Cell: most read
- Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells 2 days 20 hours old
- Patient-Specific Pluripotent Stem Cells Become Even More Accessible 2 days 20 hours old
- Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming 2 days 20 hours old
- Patients Beware: Commercialized Stem Cell Treatments on the Web 2 days 20 hours old
- Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells 2 days 20 hours old
- Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus 2 days 20 hours old
- MicroRNAs as Regulators of Differentiation and Cell Fate Decisions 2 days 20 hours old
- MicroRNA Gene Regulatory Pathways in the Establishment and Maintenance of ESC Identity 2 days 20 hours old
- Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells 2 days 20 hours old
- When Fibroblasts MET iPSCs 2 days 20 hours old
- Reprogramming of T Cells from Human Peripheral Blood 2 days 20 hours old
- Pax6 Is a Human Neuroectoderm Cell Fate Determinant 2 days 20 hours old
- An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity 2 days 20 hours old
- A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal 2 days 20 hours old
- Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins 2 days 20 hours old
PLOS Biology (new articles)
- Structure of Signaling Enzyme Reveals How Calcium Turns It On 3 days 17 hours old
- Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation 3 days 17 hours old
- PLoS Biology Issue Image | Vol. 8(7) July 2010 3 days 17 hours old
- Tracking Marsupial Evolution Using Archaic Genomic Retroposon Insertions 3 days 17 hours old
- Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification 3 days 17 hours old
- Rethinking Ecosystem Resilience in the Face of Climate Change 3 days 17 hours old
- Jumping Genes Reveal Kangaroos' Origins 3 days 17 hours old
- A Novel Role for Dbx1-Derived Cajal-Retzius Cells in Early Regionalization of the Cerebral Cortical Neuroepithelium 3 days 17 hours old
- Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases 3 days 17 hours old
- Genetic Mismatches Between Nuclei and Mitochondria Make Yeast Hybrids Sterile 1 week 3 days old
- Multiple Molecular Mechanisms Cause Reproductive Isolation between Three Yeast Species 1 week 3 days old
- The BRCT Domain of PARP-1 Is Required for Immunoglobulin Gene Conversion 1 week 3 days old
- Giving Microbes Their Due 1 week 3 days old
- Cryptic Variation between Species and the Basis of Hybrid Performance 1 week 3 days old
- MglB Fills a GAP in Bacterial Polarity and Motility 1 week 3 days old
Trends in Pharmacological Sciences
- Signaling pathways in schizophrenia: emerging targets and therapeutic strategies 3 days 20 hours old
- Fighting cancers from within: augmenting tumor immunity with cytokine therapy 3 days 20 hours old
- Small-animal positron emission tomography as a tool for neuropharmacology 3 days 20 hours old
- Structural perspectives on secondary active transporters 3 days 20 hours old
- Exploring the chemical space of γ-secretase modulators 3 days 20 hours old
- Do cannabinoids have a therapeutic role in transplantation? 3 days 20 hours old
- Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications 3 days 20 hours old
- Regulation of signal transduction by calcitonin gene-related peptide receptors 3 days 20 hours old
- Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis 3 days 20 hours old
- Peptide drugs to target G protein-coupled receptors 3 days 20 hours old
- Antivirals for pandemic influenza: a triumph of policy over evidence? 3 days 20 hours old
- Targeting homologous recombination repair defects in cancer 3 days 20 hours old
- New pharmacological targets and treatments for atrial fibrillation 3 days 20 hours old
- Use of clearance concepts and modeling techniques in the prediction of metabolic drug–drug interactions 3 days 20 hours old
- Homeopathy, a “helpful placebo”; or an unethical intervention? Edzard Ernst Reply 5 weeks 20 hours old
Nucleic Acids Research
- Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples 4 days 7 hours old
- Site-specific labeling of Saccharomyces cerevisiae ribosomes for single-molecule manipulations 4 days 7 hours old
- In vitro genetic reconstruction of bacterial transcription initiation by coupled synthesis and detection of RNA polymerase holoenzyme 4 days 7 hours old
- Designing small multiple-target artificial RNAs 4 days 7 hours old
- Combination of RNA interference and U1 inhibition leads to increased inhibition of gene expression 4 days 7 hours old
- Titration-free massively parallel pyrosequencing using trace amounts of starting material 4 days 7 hours old
- Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine 4 days 7 hours old
- Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing 4 days 7 hours old
- Quantitative design and experimental validation for a single-molecule DNA nanodevice transformable among three structural states 4 days 7 hours old
- Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes 4 days 7 hours old
- Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence 4 days 7 hours old
- A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens 4 days 7 hours old
- Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme 4 days 7 hours old
- Computational generation and screening of RNA motifs in large nucleotide sequence pools 4 days 7 hours old
- Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene 4 days 7 hours old
Bioinformatics
- Structure-based variable selection for survival data 1 week 6 days old
- Cassis: detection of genomic rearrangement breakpoints 1 week 6 days old
- SVDetect: a tool to identify genomic structural variations from paired-end and mate-pair sequencing data 1 week 6 days old
- Parallelization of the MAFFT multiple sequence alignment program 1 week 6 days old
- An alignment algorithm for bisulfite sequencing using the Applied Biosystems SOLiD System 1 week 6 days old
- COMA server for protein distant homology search 1 week 6 days old
- Cloud-Coffee: implementation of a parallel consistency-based multiple alignment algorithm in the T-Coffee package and its benchmarking on the Amazon Elastic-Cloud 1 week 6 days old
- adephylo: new tools for investigating the phylogenetic signal in biological traits 1 week 6 days old
- PESDserv: a server for high-throughput comparison of protein binding site surfaces 1 week 6 days old
- Count: evolutionary analysis of phylogenetic profiles with parsimony and likelihood 1 week 6 days old
- ViewDock TDW: high-throughput visualization of virtual screening results 1 week 6 days old
- LOX: inferring Level Of eXpression from diverse methods of census sequencing 1 week 6 days old
- MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets 1 week 6 days old
- Phenoclustering: online mining of cross-species phenotypes 1 week 6 days old
- Large-scale benchmark of Endeavour using MetaCore maps 1 week 6 days old
Genetically modified organisms (GMO)
- Altered animals: Creatures with bonus features 2 weeks 2 days old
- Europe's science-free plan for gene-modified crops 4 weeks 3 days old
- Robb Fraley: Monsanto is a champion of healthy eating 4 weeks 4 days old
- Hollow victory for Monsanto in alfalfa court case 5 weeks 3 days old
- Special report: Where next for synthetic life? 9 weeks 2 days old
Cancer Cell
- Wnt/Ca2+/NFAT Signaling Maintains Survival of Ph+ Leukemia Cells upon Inhibition of Bcr-Abl 2 weeks 3 days old
- PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3 2 weeks 3 days old
- Integrative Genomic Profiling of Human Prostate Cancer 2 weeks 3 days old
- A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma 2 weeks 3 days old
- Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors 2 weeks 3 days old
- Testimony from the Bedside: From Coley's Toxins to Targeted Immunotherapy 2 weeks 3 days old
- The Molecular Biology of Myeloproliferative Disorders 2 weeks 3 days old
- PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase 2 weeks 3 days old
- 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors 2 weeks 3 days old
- All Roads Lead to the Ribosome 2 weeks 3 days old
- HIF-1α Partners with FoxA2, a Neuroendocrine-Specific Transcription Factor, to Promote Tumorigenesis 2 weeks 3 days old
- New Views into the Prostate Cancer Genome 2 weeks 3 days old
- Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells 5 weeks 21 hours old
- Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator 5 weeks 21 hours old
- ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading 5 weeks 21 hours old