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'Zero emissions' hydrogen plane test was part powered by fossil fuels

Genetics - 13 hours 50 min ago
The first test flight of a hydrogen passenger plane, which was billed as an important move away from fossil fuels, ran on fuel produced in large part by fossil fuels, the company behind the plane has admitted
Categories: Biology

'Zero emissions' hydrogen plane test was part powered by fossil fuels

HIV and AIDS - 13 hours 50 min ago
The first test flight of a hydrogen passenger plane, which was billed as an important move away from fossil fuels, ran on fuel produced in large part by fossil fuels, the company behind the plane has admitted

A fleet of drones can be controlled by one person with a smartphone

Genetics - 13 hours 53 min ago
MultiFlyer lets one smartphone control a fleet of drones, which could be used for building inspections, crop surveys or search and rescue missions
Categories: Biology

A fleet of drones can be controlled by one person with a smartphone

HIV and AIDS - 13 hours 53 min ago
MultiFlyer lets one smartphone control a fleet of drones, which could be used for building inspections, crop surveys or search and rescue missions

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle

PLOS Biology (new articles) - 14 hours 50 min ago

by Ruth Steinberg, Andrea Origi, Ana Natriashvili, Pinku Sarmah, Mariya Licheva, Princess M. Walker, Claudine Kraft, Stephen High, Joen Luirink, Wei. Q. Shi, Martin Helmstädter, Maximilian H. Ulbrich, Hans-Georg Koch

Small membrane proteins represent a largely unexplored yet abundant class of proteins in pro- and eukaryotes. They essentially consist of a single transmembrane domain and are associated with stress response mechanisms in bacteria. How these proteins are inserted into the bacterial membrane is unknown. Our study revealed that in Escherichia coli, the 27-amino-acid-long model protein YohP is recognized by the signal recognition particle (SRP), as indicated by in vivo and in vitro site-directed cross-linking. Cross-links to SRP were also observed for a second small membrane protein, the 33-amino-acid-long YkgR. However, in contrast to the canonical cotranslational recognition by SRP, SRP was found to bind to YohP posttranslationally. In vitro protein transport assays in the presence of a SecY inhibitor and proteoliposome studies demonstrated that SRP and its receptor FtsY are essential for the posttranslational membrane insertion of YohP by either the SecYEG translocon or by the YidC insertase. Furthermore, our data showed that the yohP mRNA localized preferentially and translation-independently to the bacterial membrane in vivo. In summary, our data revealed that YohP engages an unique SRP-dependent posttranslational insertion pathway that is likely preceded by an mRNA targeting step. This further highlights the enormous plasticity of bacterial protein transport machineries.
Categories: Biology, Journals

Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer

PLOS Biology (new articles) - 14 hours 50 min ago

by Lisa Selzer, Zhaoming Su, Grigore D. Pintilie, Wah Chiu, Karla Kirkegaard

Matrix proteins are encoded by many enveloped viruses, including influenza viruses, herpes viruses, and coronaviruses. Underneath the viral envelope of influenza virus, matrix protein 1 (M1) forms an oligomeric layer critical for particle stability and pH-dependent RNA genome release. However, high-resolution structures of full-length monomeric M1 and the matrix layer have not been available, impeding antiviral targeting and understanding of the pH-dependent transitions involved in cell entry. Here, purification and extensive mutagenesis revealed protein–protein interfaces required for the formation of multilayered helical M1 oligomers similar to those observed in virions exposed to the low pH of cell entry. However, single-layered helical oligomers with biochemical and ultrastructural similarity to those found in infectious virions before cell entry were observed upon mutation of a single amino acid. The highly ordered structure of the single-layered oligomers and their likeness to the matrix layer of intact virions prompted structural analysis by cryo-electron microscopy (cryo-EM). The resulting 3.4-Å–resolution structure revealed the molecular details of M1 folding and its organization within the single-shelled matrix. The solution of the full-length M1 structure, the identification of critical assembly interfaces, and the development of M1 assembly assays with purified proteins are crucial advances for antiviral targeting of influenza viruses.
Categories: Biology, Journals

World leaders pledge to protect nature – will it make a difference?

Genetics - Wed, 2020-09-30 21:29
The sheer number of global leaders pledging to protect nature at a virtual UN biodiversity summit is progress – but we need more than warm words to limit habitat loss and species extinction
Categories: Biology

World leaders pledge to protect nature – will it make a difference?

HIV and AIDS - Wed, 2020-09-30 21:29
The sheer number of global leaders pledging to protect nature at a virtual UN biodiversity summit is progress – but we need more than warm words to limit habitat loss and species extinction

What should a second coronavirus lockdown look like in Europe?

Genetics - Wed, 2020-09-30 20:00
As cases rise across Western Europe, are second lockdowns inevitable? If so, what should they look like and will they be different to last time?
Categories: Biology

What should a second coronavirus lockdown look like in Europe?

HIV and AIDS - Wed, 2020-09-30 20:00
As cases rise across Western Europe, are second lockdowns inevitable? If so, what should they look like and will they be different to last time?

Covid-19 news: UK MPs to be given more say on new coronavirus measures

Genetics - Wed, 2020-09-30 19:59
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Categories: Biology

Covid-19 news: UK MPs to be given more say on new coronavirus measures

HIV and AIDS - Wed, 2020-09-30 19:59
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

Most Zoombombing is not done by external hackers – they're inside jobs

Genetics - Wed, 2020-09-30 18:58
Zoombombing, a kind of virtual gatecrashing that has been used to spread harassment and hate speech, has become a serious problem during the pandemic. An analysis of this behaviour shows the majority of Zoombombers get access from insiders rather than hacking in
Categories: Biology

Most Zoombombing is not done by external hackers – they're inside jobs

HIV and AIDS - Wed, 2020-09-30 18:58
Zoombombing, a kind of virtual gatecrashing that has been used to spread harassment and hate speech, has become a serious problem during the pandemic. An analysis of this behaviour shows the majority of Zoombombers get access from insiders rather than hacking in

Why we're in for a long wait to hear from intelligent aliens

Genetics - Wed, 2020-09-30 14:00
Hints of bacteria on Venus are encouraging, but finding life beyond Earth is the easy part. A new analysis suggests the evolution of human-like intelligence on another planet is more improbable than we like to imagine
Categories: Biology

Why we're in for a long wait to hear from intelligent aliens

HIV and AIDS - Wed, 2020-09-30 14:00
Hints of bacteria on Venus are encouraging, but finding life beyond Earth is the easy part. A new analysis suggests the evolution of human-like intelligence on another planet is more improbable than we like to imagine

We may be able to tell someone's heart rate just by looking at them

Genetics - Wed, 2020-09-30 12:11
Researchers asked volunteers to match an on-screen heart rate to videos of people's faces, and the participants were able to guess better than chance. It could be that this ability helps us judge other people's emotions
Categories: Biology

We may be able to tell someone's heart rate just by looking at them

HIV and AIDS - Wed, 2020-09-30 12:11
Researchers asked volunteers to match an on-screen heart rate to videos of people's faces, and the participants were able to guess better than chance. It could be that this ability helps us judge other people's emotions

Surgical device inspired by parasitic wasps could extract bits of you

Genetics - Wed, 2020-09-30 07:15
Parasitic wasps use a long, thin, tubular organ to implant eggs in their victims. A device inspired by this organ could make it easier and less painful to remove tumours, blood clots or even whole organs
Categories: Biology

Surgical device inspired by parasitic wasps could extract bits of you

HIV and AIDS - Wed, 2020-09-30 07:15
Parasitic wasps use a long, thin, tubular organ to implant eggs in their victims. A device inspired by this organ could make it easier and less painful to remove tumours, blood clots or even whole organs