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Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

PLOS Biology (new articles) - 12 hours 33 min ago

by Noriki Fujimoto, Yuliang He, Marco D’Addio, Carlotta Tacconi, Michael Detmar, Lothar C. Dieterich

Lymph nodes (LNs) are highly organized secondary lymphoid organs that mediate adaptive immune responses to antigens delivered via afferent lymphatic vessels. Lymphatic endothelial cells (LECs) line intranodal lymphatic sinuses and organize lymph and antigen distribution. LECs also directly regulate T cells, mediating peripheral tolerance to self-antigens, and play a major role in many diseases, including cancer metastasis. However, little is known about the phenotypic and functional heterogeneity of LN LECs. Using single-cell RNA sequencing, we comprehensively defined the transcriptome of LECs in murine skin-draining LNs and identified new markers and functions of distinct LEC subpopulations. We found that LECs residing in the subcapsular sinus (SCS) have an unanticipated function in scavenging of modified low-density lipoprotein (LDL) and also identified a specific cortical LEC subtype implicated in rapid lymphocyte egress from LNs. Our data provide new, to our knowledge, insights into the diversity of LECs in murine LNs and a rich resource for future studies into the regulation of immune responses by LN LECs.
Categories: Biology, Journals

How realistic is Contagion? The movie doesn't skimp on science

Genetics - Mon, 2020-04-06 18:48
Contagion was a film released in 2011 about a fictional pandemic of a virus called MEV-1 which kills between 25 and 30 per cent of those it infected. Here is our review of the film originally published in September 2011, now that it's on Netflix
Categories: Biology

How realistic is Contagion? The movie doesn't skimp on science

HIV and AIDS - Mon, 2020-04-06 18:48
Contagion was a film released in 2011 about a fictional pandemic of a virus called MEV-1 which kills between 25 and 30 per cent of those it infected. Here is our review of the film originally published in September 2011, now that it's on Netflix

How realistic is Contagion? The movie doesn't skimp on science

Genetically modified organisms (GMO) - Mon, 2020-04-06 18:48
Contagion was a film released in 2011 about a fictional pandemic of a virus called MEV-1 which kills between 25 and 30 per cent of those it infected. Here is our review of the film originally published in September 2011, now that it's on Netflix
Categories: Science and society

An asteroid strike may have popped the surface of Mars

Genetics - Mon, 2020-04-06 18:40
An unusually round and symmetrical deposit on Mars may be the result of an impact that popped the surface of the planet, causing a volcanic eruption less than 200,000 years ago
Categories: Biology

An asteroid strike may have popped the surface of Mars

HIV and AIDS - Mon, 2020-04-06 18:40
An unusually round and symmetrical deposit on Mars may be the result of an impact that popped the surface of the planet, causing a volcanic eruption less than 200,000 years ago

An asteroid strike may have popped the surface of Mars

Genetically modified organisms (GMO) - Mon, 2020-04-06 18:40
An unusually round and symmetrical deposit on Mars may be the result of an impact that popped the surface of the planet, causing a volcanic eruption less than 200,000 years ago
Categories: Science and society

Coronavirus latest: US braces for 'peak death week'

Genetics - Mon, 2020-04-06 18:30
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Categories: Biology

Coronavirus latest: US braces for 'peak death week'

HIV and AIDS - Mon, 2020-04-06 18:30
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

Coronavirus latest: US braces for 'peak death week'

Genetically modified organisms (GMO) - Mon, 2020-04-06 18:30
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Categories: Science and society

Soil gets its smell from bacteria trying to attract invertebrates

Genetics - Mon, 2020-04-06 18:00
Soil’s earthy smell comes from chemicals produced by bacteria called Streptomyces, which use the odour to attract springtails to help disperse their spores
Categories: Biology

Soil gets its smell from bacteria trying to attract invertebrates

HIV and AIDS - Mon, 2020-04-06 18:00
Soil’s earthy smell comes from chemicals produced by bacteria called Streptomyces, which use the odour to attract springtails to help disperse their spores

Soil gets its smell from bacteria trying to attract invertebrates

Genetically modified organisms (GMO) - Mon, 2020-04-06 18:00
Soil’s earthy smell comes from chemicals produced by bacteria called Streptomyces, which use the odour to attract springtails to help disperse their spores
Categories: Science and society

Deepmind AI can understand the unusual atomic structure of glass

Genetics - Mon, 2020-04-06 18:00
Glass has an unusual atomic structure that resembles a liquid frozen in place, making it hard to predict how it will behave. DeepMind has developed an AI capable of doing so, which may also be able to predict traffic jams
Categories: Biology

Deepmind AI can understand the unusual atomic structure of glass

HIV and AIDS - Mon, 2020-04-06 18:00
Glass has an unusual atomic structure that resembles a liquid frozen in place, making it hard to predict how it will behave. DeepMind has developed an AI capable of doing so, which may also be able to predict traffic jams

Deepmind AI can understand the unusual atomic structure of glass

Genetically modified organisms (GMO) - Mon, 2020-04-06 18:00
Glass has an unusual atomic structure that resembles a liquid frozen in place, making it hard to predict how it will behave. DeepMind has developed an AI capable of doing so, which may also be able to predict traffic jams
Categories: Science and society

Baffling 500-page ABC maths proof to be published after eight-year row

Genetics - Mon, 2020-04-06 16:46
In 2012, mathematician Shinichi Mochizuki produced a proof claiming to solve the long-standing ABC conjecture, but no one understood it. Most mathematicians still don't, but it will now be published in a journal
Categories: Biology

Baffling 500-page ABC maths proof to be published after eight-year row

HIV and AIDS - Mon, 2020-04-06 16:46
In 2012, mathematician Shinichi Mochizuki produced a proof claiming to solve the long-standing ABC conjecture, but no one understood it. Most mathematicians still don't, but it will now be published in a journal

Baffling 500-page ABC maths proof to be published after eight-year row

Genetically modified organisms (GMO) - Mon, 2020-04-06 16:46
In 2012, mathematician Shinichi Mochizuki produced a proof claiming to solve the long-standing ABC conjecture, but no one understood it. Most mathematicians still don't, but it will now be published in a journal
Categories: Science and society

Whale sharks can live for at least 50 years – and probably longer

Genetics - Mon, 2020-04-06 07:00
The age of a whale shark can be determined by dating the rings of growth in their cartilage, a method that has confirmed that these animals can live for at least 50 years
Categories: Biology