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Eternal black holes are the ultimate cosmic safes

HIV and AIDS - Fri, 2010-09-03 19:59
Normally, black holes evaporate over time, a process that probably releases information about their contents – but there may be a way to create black holes that stand the test of time


Edible crystals could store hydrogen fuel

HIV and AIDS - Fri, 2010-09-03 18:56
Molecular cages for storing hydrogen fuel have been made from cheap, natural ingredients – and they taste like crackers


Pakistan's flood weather eased Atlantic hurricanes

HIV and AIDS - Fri, 2010-09-03 17:45
The stalled weather pattern behind floods in Pakistan and a heatwave in Russia may have delayed the start of the Atlantic hurricane season


Trojan asteroids make planetary scientist lose sleep

HIV and AIDS - Fri, 2010-09-03 17:33
The sizes of asteroids near Jupiter spell trouble for the leading theory of how our solar system evolved


Computer games may be spawning reckless drivers

HIV and AIDS - Fri, 2010-09-03 16:59
Young drivers who played car-based computer games in their mid-teens are more likely to say they drive fast and dangerously in the real world


Humans with monkeypox virus cases rocket

HIV and AIDS - Fri, 2010-09-03 16:54
A 20-fold jump in the number of humans with a smallpox-related virus in Congo has provoked a call to assess its global threat


Why your brain flips over visual illusions

HIV and AIDS - Fri, 2010-09-03 14:50
What happens in your brain when you view illusions in which two separate images can be seen?


Nano-engineered cotton promises to wipe out water bugs

HIV and AIDS - Fri, 2010-09-03 14:17
Cotton impregnated with silver nanowires and carbon nanotubes could provide a cheap and effective method of purifying water in remote locations


Why the 'sixth extinction' will be unpredictable

HIV and AIDS - Fri, 2010-09-03 13:19
The fallout from the current mass extinction of life on Earth will be far from simple to predict


Second super-fast flip of Earth's poles found

HIV and AIDS - Fri, 2010-09-03 13:04
Theory says the Earth's magnetic field can't flip in just a few years, yet for the second time evidence has been found of it happening in the past


Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Ivan Matic, Joost Schimmel, Ivo A. Hendriks, Maria A. van Santen, Frans van de Rijke, Hans van Dam, Florian Gnad, Matthias Mann, Alfred C.O. Vertegaal. Reversible protein modification by small ubiquitin-like modifiers (SUMOs) is critical for eukaryotic life. Mass spectrometry-based proteomics has proven effective at identifying hundreds of potent....

Identification of Regulators of Chaperone-Mediated Autophagy

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Urmi Bandyopadhyay, Sunandini Sridhar, Susmita Kaushik, Roberta Kiffin, Ana Maria Cuervo. Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of cytosolic proteins in lysosomes that contributes to cellular quality control and becomes an additional source of ....

The Three-Dimensional Organization of Polyribosomes in Intact Human Cells

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Florian Brandt, Lars-Anders Carlson, F. Ulrich Hartl, Wolfgang Baumeister, Kay Grünewald. Structural studies have provided detailed insights into different functional states of the ribosome and its interaction with factors involved in nascent peptide folding, processing, and targeting.....

UPF1 Association with the Cap-Binding Protein, CBP80, Promotes Nonsense-Mediated mRNA Decay at Two Distinct Steps

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Jungwook Hwang, Hanae Sato, Yalan Tang, Daiki Matsuda, Lynne E. Maquat. Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that in mammals generally occurs upon recognition of a premature termination codon (PTC) during a pioneer round of translation.....

Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Junming Yue, Yunhui Cheng, Huazhang Guo, Alyssa Bolen, Chunxiang Zhang, Louisa Balazs, Fabio Re, Guangwei Du, Michael A. Frohman, Daniel L. Baker, Abby L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi, Kimiko Murakami-Murofushi, Gabor Tigyi. Cyclic phosphatidic acid (1-acyl-2,3-cyclic-glycerophosphate, CPA), one of nature's simplest phospholipids, is found in cells from slime mold to humans and has a largely unknown function. We find ....

Spindle Position Is Coordinated with Cell-Cycle Progression through Establishment of Mitotic Exit-Activating and -Inhibitory Zones

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Leon Y. Chan, Angelika Amon. How spatial information is translated into a chemical signal is a fundamental problem in all organisms. The spindle position checkpoint is a prime example of this problem. This checkpoint senses s....

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Sarah Lambert, Ken'ichi Mizuno, Joël Blaisonneau, Sylvain Martineau, Roland Chanet, Karine Fréon, Johanne M. Murray, Antony M. Carr, Giuseppe Baldacci. Template switching induced by stalled replication forks has recently been proposed to underlie complex genomic rearrangements. However, the resulting models are not supported by robust physical ev....

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Sébastien Thibeault, Yohann Rautureau, Malika Oubaha, Denis Faubert, Brian C. Wilkes, Chantal Delisle, Jean-Philippe Gratton. Disruption of adherens junctions between endothelial cells results in compromised endothelial barrier function and in altered angiogenesis. Nitric oxide (NO) produced by endothelial NO synthase (e....

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Dimitrios Iliopoulos, Savina A. Jaeger, Heather A. Hirsch, Martha L. Bulyk, Kevin Struhl. A transient inflammatory signal can initiate an epigenetic switch from nontransformed to cancer cells via a positive feedback loop involving NF-κB, Lin28, let-7, and IL-6. We identify differential....

The Methyltransferase Activity of Clr4Suv39h Triggers RNAi Independently of Histone H3K9 Methylation

Molecular Cell (most read) - Fri, 2010-09-03 06:30
Erica L. Gerace, Mario Halic, Danesh Moazed. In fission yeast, the pericentromeric dg and dh repeats are transcribed and give rise to small interfering RNAs (siRNAs) by a mechanism that depends on the Clr4suv39h hist....