Timothy N. Phoenix, Richard J. Gilbertson. Brain tumors display extensive diversity. In this issue of Cancer Cell, Swartling et al. provide evidence that the temporal and spatial transcriptional programs in neural stem cells underli....

Yao-Cheng Li, Geoffrey M. Wahl. In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critic....

Lei Jin, John C. Cambier. CD37 is a tetraspannin that triggers cell death and is a potential therapeutic target in cancers. In this issue of Cancer Cell, Lapalombella et al. show that CD37 is tyrosine phosphorylated....

Mariano Barbacid. In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmaco....

Fredrik J. Swartling, Vasil Savov, Anders I. Persson, Justin Chen, Christopher S. Hackett, Paul A. Northcott, Matthew R. Grimmer, Jasmine Lau, Louis Chesler, Arie Perry, Joanna J. Phillips, Michael D. Taylor, William A. Weiss. The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or m....

Xin Yu, Alexei Vazquez, Arnold J. Levine, Darren R. Carpizo. Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we identified two compounds from the th....

Keli Xu, Jerry Usary, Philaretos C. Kousis, Aleix Prat, Dong-Yu Wang, Jessica R. Adams, Wei Wang, Amanda J. Loch, Tao Deng, Wei Zhao, Robert Darrell Cardiff, Keejung Yoon, Nicholas Gaiano, Vicki Ling, Joseph Beyene, Eldad Zacksenhaus, Tom Gridley, Wey L. Leong, Cynthia J. Guidos, Charles M. Perou, Sean E. Egan. Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary gland, while suppressing stem cell se....

Jiehui Deng, Yong Liu, Heehyoung Lee, Andreas Herrmann, Wang Zhang, Chunyan Zhang, Shudan Shen, Saul J. Priceman, Maciej Kujawski, Sumanta K. Pal, Andrew Raubitschek, Dave S.B. Hoon, Stephen Forman, Robert A. Figlin, Jie Liu, Richard Jove, Hua Yu. Recent studies underscore the importance of myeloid cells in rendering distant organs hospitable for disseminating tumor cells to colonize. However, what enables myeloid cells to have an apparentl....

Daniel D. De Carvalho, Shikhar Sharma, Jueng Soo You, Sheng-Fang Su, Phillippa C. Taberlay, Theresa K. Kelly, Xiaojing Yang, Gangning Liang, Peter A. Jones. Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant transformation. Whether cancer cells are dependent on these abnormal epigenetic modifications remains elus....

Hugh S. Gannon, Bruce A. Woda, Stephen N. Jones. DNA damage induced by ionizing radiation activates the ATM kinase, which subsequently stabilizes and activates the p53 tumor suppressor protein. Although phosphorylation of p53 by ATM was found pr....

Myron S. Ignatius, Eleanor Chen, Natalie M. Elpek, Adam Z. Fuller, Inês M. Tenente, Ryan Clagg, Sali Liu, Jessica S. Blackburn, Corinne M. Linardic, Andrew E. Rosenberg, Petur G. Nielsen, Thorsten R. Mempel, David M. Langenau. Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here, we show that ERMS-propagating potential is confined to myf5+ cells and can be visualized in live, fluor....

Rosa Lapalombella, Yuh-Ying Yeh, Liwen Wang, Asha Ramanunni, Sarwish Rafiq, Shruti Jha, Justin Staubli, David M. Lucas, Rajeswaran Mani, Sarah E.M. Herman, Amy J. Johnson, Arletta Lozanski, Leslie Andritsos, Jeffrey Jones, Joseph M. Flynn, Brian Lannutti, Peter Thompson, Paul Algate, Scott Stromatt, David Jarjoura, Xiaokui Mo, Dasheng Wang, Ching-Shih Chen, Gerard Lozanski, Nyla A. Heerema, Susheela Tridandapani, Michael A. Freitas, Natarajan Muthusamy, John C. Byrd. Tetraspanins are commonly believed to act only as “molecular facilitators,” with no direct role in signal transduction. We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expre....

Svetlana Kotliarova, Howard A. Fine.

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