Normally, black holes evaporate over time, a process that probably releases information about their contents – but there may be a way to create black holes that stand the test of time

Molecular cages for storing hydrogen fuel have been made from cheap, natural ingredients – and they taste like crackers

The stalled weather pattern behind floods in Pakistan and a heatwave in Russia may have delayed the start of the Atlantic hurricane season

The sizes of asteroids near Jupiter spell trouble for the leading theory of how our solar system evolved

Young drivers who played car-based computer games in their mid-teens are more likely to say they drive fast and dangerously in the real world

A 20-fold jump in the number of humans with a smallpox-related virus in Congo has provoked a call to assess its global threat

What happens in your brain when you view illusions in which two separate images can be seen?

Cotton impregnated with silver nanowires and carbon nanotubes could provide a cheap and effective method of purifying water in remote locations

The fallout from the current mass extinction of life on Earth will be far from simple to predict

Theory says the Earth's magnetic field can't flip in just a few years, yet for the second time evidence has been found of it happening in the past

Ivan Matic, Joost Schimmel, Ivo A. Hendriks, Maria A. van Santen, Frans van de Rijke, Hans van Dam, Florian Gnad, Matthias Mann, Alfred C.O. Vertegaal. Reversible protein modification by small ubiquitin-like modifiers (SUMOs) is critical for eukaryotic life. Mass spectrometry-based proteomics has proven effective at identifying hundreds of potent....

Urmi Bandyopadhyay, Sunandini Sridhar, Susmita Kaushik, Roberta Kiffin, Ana Maria Cuervo. Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of cytosolic proteins in lysosomes that contributes to cellular quality control and becomes an additional source of ....

Florian Brandt, Lars-Anders Carlson, F. Ulrich Hartl, Wolfgang Baumeister, Kay Grünewald. Structural studies have provided detailed insights into different functional states of the ribosome and its interaction with factors involved in nascent peptide folding, processing, and targeting.....

Jungwook Hwang, Hanae Sato, Yalan Tang, Daiki Matsuda, Lynne E. Maquat. Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that in mammals generally occurs upon recognition of a premature termination codon (PTC) during a pioneer round of translation.....

Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Junming Yue, Yunhui Cheng, Huazhang Guo, Alyssa Bolen, Chunxiang Zhang, Louisa Balazs, Fabio Re, Guangwei Du, Michael A. Frohman, Daniel L. Baker, Abby L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi, Kimiko Murakami-Murofushi, Gabor Tigyi. Cyclic phosphatidic acid (1-acyl-2,3-cyclic-glycerophosphate, CPA), one of nature's simplest phospholipids, is found in cells from slime mold to humans and has a largely unknown function. We find ....

Leon Y. Chan, Angelika Amon. How spatial information is translated into a chemical signal is a fundamental problem in all organisms. The spindle position checkpoint is a prime example of this problem. This checkpoint senses s....

Sarah Lambert, Ken'ichi Mizuno, Joël Blaisonneau, Sylvain Martineau, Roland Chanet, Karine Fréon, Johanne M. Murray, Antony M. Carr, Giuseppe Baldacci. Template switching induced by stalled replication forks has recently been proposed to underlie complex genomic rearrangements. However, the resulting models are not supported by robust physical ev....

Sébastien Thibeault, Yohann Rautureau, Malika Oubaha, Denis Faubert, Brian C. Wilkes, Chantal Delisle, Jean-Philippe Gratton. Disruption of adherens junctions between endothelial cells results in compromised endothelial barrier function and in altered angiogenesis. Nitric oxide (NO) produced by endothelial NO synthase (e....

Dimitrios Iliopoulos, Savina A. Jaeger, Heather A. Hirsch, Martha L. Bulyk, Kevin Struhl. A transient inflammatory signal can initiate an epigenetic switch from nontransformed to cancer cells via a positive feedback loop involving NF-κB, Lin28, let-7, and IL-6. We identify differential....

Erica L. Gerace, Mario Halic, Danesh Moazed. In fission yeast, the pericentromeric dg and dh repeats are transcribed and give rise to small interfering RNAs (siRNAs) by a mechanism that depends on the Clr4suv39h hist....