Feed aggregator

Australia’s fires may accelerate a jump in CO2 forecasted in 2020

Genetics - 7 hours 25 min ago
The UK’s Met Office is forecasting a big increase in CO2 levels in 2020, due in part to the extreme wildfires that have been burning for months in Australia
Categories: Biology

Australia’s fires may accelerate a jump in CO2 forecasted in 2020

HIV and AIDS - 7 hours 25 min ago
The UK’s Met Office is forecasting a big increase in CO2 levels in 2020, due in part to the extreme wildfires that have been burning for months in Australia

Star Trek: Picard explores what happens when robots go rogue

Genetics - 7 hours 25 min ago
Patrick Stewart returns in triumphant new Star Trek spin-off Picard, but the Federation's robots are missing, discontinued, and for a very good reason
Categories: Biology

Star Trek: Picard explores what happens when robots go rogue

HIV and AIDS - 7 hours 25 min ago
Patrick Stewart returns in triumphant new Star Trek spin-off Picard, but the Federation's robots are missing, discontinued, and for a very good reason

Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform

PLOS Biology (new articles) - 9 hours 27 min ago

by Charles Blatti III, Amin Emad, Matthew J. Berry, Lisa Gatzke, Milt Epstein, Daniel Lanier, Pramod Rizal, Jing Ge, Xiaoxia Liao, Omar Sobh, Mike Lambert, Corey S. Post, Jinfeng Xiao, Peter Groves, Aidan T. Epstein, Xi Chen, Subhashini Srinivasan, Erik Lehnert, Krishna R. Kalari, Liewei Wang, Richard M. Weinshilboum, Jun S. Song, C. Victor Jongeneel, Jiawei Han, Umberto Ravaioli, Nahil Sobh, Colleen B. Bushell, Saurabh Sinha

We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis. The system specializes in “knowledge-guided” data mining and machine learning algorithms, in which user-provided data are analyzed in light of prior information about genes, aggregated from numerous knowledge bases and encoded in a massive “Knowledge Network.” KnowEnG adheres to “FAIR” principles (findable, accessible, interoperable, and reuseable): its tools are easily portable to diverse computing environments, run on the cloud for scalable and cost-effective execution, and are interoperable with other computing platforms. The analysis tools are made available through multiple access modes, including a web portal with specialized visualization modules. We demonstrate the KnowEnG system’s potential value in democratization of advanced tools for the modern genomics era through several case studies that use its tools to recreate and expand upon the published analysis of cancer data sets.
Categories: Biology, Journals

Temporal information loss in the macaque early visual system

PLOS Biology (new articles) - 9 hours 27 min ago

by Gregory D. Horwitz

Stimuli that modulate neuronal activity are not always detectable, indicating a loss of information between the modulated neurons and perception. To identify where in the macaque visual system information about periodic light modulations is lost, signal-to-noise ratios were compared across simulated cone photoreceptors, lateral geniculate nucleus (LGN) neurons, and perceptual judgements. Stimuli were drifting, threshold-contrast Gabor patterns on a photopic background. The sensitivity of LGN neurons, extrapolated to populations, was similar to the monkeys' at low temporal frequencies. At high temporal frequencies, LGN sensitivity exceeded the monkeys' and approached the upper bound set by cone photocurrents. These results confirm a loss of high-frequency information downstream of the LGN. However, this loss accounted for only about 5% of the total. Phototransduction accounted for essentially all of the rest. Together, these results show that low temporal frequency information is lost primarily between the cones and the LGN, whereas high-frequency information is lost primarily within the cones, with a small additional loss downstream of the LGN.
Categories: Biology, Journals

Antibiotic resistance genes can be passed around by bacteria in dust

HIV and AIDS - Thu, 2020-01-23 21:00
Disease-causing bacteria living in dust can pass antibiotic resistance genes to one another, a study of samples of dust in public buildings suggests

Antibiotic resistance genes can be passed around by bacteria in dust

Genetics - Thu, 2020-01-23 21:00
Disease-causing bacteria living in dust can pass antibiotic resistance genes to one another, a study of samples of dust in public buildings suggests
Categories: Biology

Antibiotic resistance genes can be passed around by bacteria in dust

Genetically modified organisms (GMO) - Thu, 2020-01-23 21:00
Disease-causing bacteria living in dust can pass antibiotic resistance genes to one another, a study of samples of dust in public buildings suggests
Categories: Science and society

Mysteriously bright supernova may have smashed up a huge gas cloud

HIV and AIDS - Thu, 2020-01-23 21:00
A strange supernova that’s 100 times brighter than it should be has long been a mystery, but it may be explained by the explosion slamming into a cloud of gas

Mysteriously bright supernova may have smashed up a huge gas cloud

Genetics - Thu, 2020-01-23 21:00
A strange supernova that’s 100 times brighter than it should be has long been a mystery, but it may be explained by the explosion slamming into a cloud of gas
Categories: Biology

Mysteriously bright supernova may have smashed up a huge gas cloud

Genetically modified organisms (GMO) - Thu, 2020-01-23 21:00
A strange supernova that’s 100 times brighter than it should be has long been a mystery, but it may be explained by the explosion slamming into a cloud of gas
Categories: Science and society

First suspected cases of the Wuhan coronavirus in the UK

HIV and AIDS - Thu, 2020-01-23 19:56
Three people are being tested in Edinburgh, UK, for the new coronavirus that first emerged in Wuhan, China, and a fourth possible case is suspected in Glasgow

First suspected cases of the Wuhan coronavirus in the UK

Genetics - Thu, 2020-01-23 19:56
Three people are being tested in Edinburgh, UK, for the new coronavirus that first emerged in Wuhan, China, and a fourth possible case is suspected in Glasgow
Categories: Biology

First suspected cases of the Wuhan coronavirus in the UK

Genetically modified organisms (GMO) - Thu, 2020-01-23 19:56
Three people are being tested in Edinburgh, UK, for the new coronavirus that first emerged in Wuhan, China, and a fourth possible case is suspected in Glasgow
Categories: Science and society

Listen to the groaning voice of a 3000-year-old Egyptian mummy

HIV and AIDS - Thu, 2020-01-23 18:00
By recreating a mummy’s vocal tract through 3D printing, we now know what an ancient Egyptian priest sounded like

Listen to the groaning voice of a 3000-year-old Egyptian mummy

Genetics - Thu, 2020-01-23 18:00
By recreating a mummy’s vocal tract through 3D printing, we now know what an ancient Egyptian priest sounded like
Categories: Biology

Listen to the groaning voice of a 3000-year-old Egyptian mummy

Genetically modified organisms (GMO) - Thu, 2020-01-23 18:00
By recreating a mummy’s vocal tract through 3D printing, we now know what an ancient Egyptian priest sounded like
Categories: Science and society

Snake cells grown in the lab produce venom we could use as medicine

HIV and AIDS - Thu, 2020-01-23 18:00
Snakes are currently "milked" for their venom to produce antidotes, but lab-grown glands could mean we can avoid having to keep the reptiles on farms

Snake cells grown in the lab produce venom we could use as medicine

Genetics - Thu, 2020-01-23 18:00
Snakes are currently "milked" for their venom to produce antidotes, but lab-grown glands could mean we can avoid having to keep the reptiles on farms
Categories: Biology