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Cell aging preserves cellular immortality in the presence of lethal levels of damage

PLOS Biology (new articles) - 3 hours 51 min ago

by Audrey Menegaz Proenca, Camilla Ulla Rang, Andrew Qiu, Chao Shi, Lin Chao

Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells. Here, we show that Escherichia coli cell lineages exhibit comparable patterns of mortality and immortality. Through single-cell microscopy and microfluidic techniques, we find that these patterns are explained by the dynamics of damage accumulation and asymmetric partitioning between daughter cells. At low damage accumulation rates, both aging and rejuvenating lineages retain immortality by reaching their respective states of physiological equilibrium. We show that both asymmetry and equilibrium are present in repair mutants lacking certain repair chaperones, suggesting that intact repair capacity is not essential for immortal proliferation. We show that this growth equilibrium, however, is displaced by extrinsic damage in a dosage-dependent response. Moreover, we demonstrate that aging lineages become mortal when damage accumulation rates surpass a threshold, whereas rejuvenating lineages within the same population remain immortal. Thus, the processes of damage accumulation and partitioning through asymmetric cell division are essential in the determination of proliferative mortality and immortality in bacterial populations. This study provides further evidence for the characterization of cellular aging as a general process, affecting prokaryotes and eukaryotes alike and according to similar evolutionary constraints.
Categories: Biology, Journals

High-tech wood could keep homes cool by reflecting the sun’s rays

Genetics - Thu, 2019-05-23 21:00
A new type of wood material that reflects sunlight could keep homes cool and cut energy used for air conditioning
Categories: Biology

High-tech wood could keep homes cool by reflecting the sun’s rays

HIV and AIDS - Thu, 2019-05-23 21:00
A new type of wood material that reflects sunlight could keep homes cool and cut energy used for air conditioning

High-tech wood could keep homes cool by reflecting the sun’s rays

Genetically modified organisms (GMO) - Thu, 2019-05-23 21:00
A new type of wood material that reflects sunlight could keep homes cool and cut energy used for air conditioning
Categories: Science and society

The tiniest fish are the most important for healthy coral reefs

Genetics - Thu, 2019-05-23 21:00
It turns out that tiny fish are crucial to supporting larger animals on and around a healthy coral reef
Categories: Biology

The tiniest fish are the most important for healthy coral reefs

HIV and AIDS - Thu, 2019-05-23 21:00
It turns out that tiny fish are crucial to supporting larger animals on and around a healthy coral reef

The tiniest fish are the most important for healthy coral reefs

Genetically modified organisms (GMO) - Thu, 2019-05-23 21:00
It turns out that tiny fish are crucial to supporting larger animals on and around a healthy coral reef
Categories: Science and society

The backlash against face recognition has begun – but who will win?

Genetics - Thu, 2019-05-23 16:46
Face recognition technology is being rolled out across the world, but activists and politicians are starting to push back on creeping surveillance
Categories: Biology

The backlash against face recognition has begun – but who will win?

HIV and AIDS - Thu, 2019-05-23 16:46
Face recognition technology is being rolled out across the world, but activists and politicians are starting to push back on creeping surveillance

The backlash against face recognition has begun – but who will win?

Genetically modified organisms (GMO) - Thu, 2019-05-23 16:46
Face recognition technology is being rolled out across the world, but activists and politicians are starting to push back on creeping surveillance
Categories: Science and society

SpaceX is launching 60 satellites to start its global internet scheme

Genetics - Thu, 2019-05-23 16:22
On Thursday, SpaceX will launch 60 spacecraft on a single rocket to start a planned fleet of 12,000 broadband internet satellites
Categories: Biology

SpaceX is launching 60 satellites to start its global internet scheme

HIV and AIDS - Thu, 2019-05-23 16:22
On Thursday, SpaceX will launch 60 spacecraft on a single rocket to start a planned fleet of 12,000 broadband internet satellites

SpaceX is launching 60 satellites to start its global internet scheme

Genetically modified organisms (GMO) - Thu, 2019-05-23 16:22
On Thursday, SpaceX will launch 60 spacecraft on a single rocket to start a planned fleet of 12,000 broadband internet satellites
Categories: Science and society

Chimpanzees eat tortoises after smashing them open on tree trunks

Genetics - Thu, 2019-05-23 16:00
A group of chimpanzees in Gabon has figured out how to eat tortoises by cracking open their shells against tree trunks — further evidence of the apes’ ingenuity
Categories: Biology

Chimpanzees eat tortoises after smashing them open on tree trunks

HIV and AIDS - Thu, 2019-05-23 16:00
A group of chimpanzees in Gabon has figured out how to eat tortoises by cracking open their shells against tree trunks — further evidence of the apes’ ingenuity

Chimpanzees eat tortoises after smashing them open on tree trunks

Genetically modified organisms (GMO) - Thu, 2019-05-23 16:00
A group of chimpanzees in Gabon has figured out how to eat tortoises by cracking open their shells against tree trunks — further evidence of the apes’ ingenuity
Categories: Science and society

Robots conduct daily health inspections of schoolchildren in China

Genetics - Thu, 2019-05-23 14:00
Thousands of preschools in China are using robots to give students heath checks. Each morning they examine pupils looking for signs of contagious diseases
Categories: Biology

Robots conduct daily health inspections of schoolchildren in China

HIV and AIDS - Thu, 2019-05-23 14:00
Thousands of preschools in China are using robots to give students heath checks. Each morning they examine pupils looking for signs of contagious diseases

Robots conduct daily health inspections of schoolchildren in China

Genetically modified organisms (GMO) - Thu, 2019-05-23 14:00
Thousands of preschools in China are using robots to give students heath checks. Each morning they examine pupils looking for signs of contagious diseases
Categories: Science and society

Polarisation on social media could be reduced with a few simple tweaks

Genetics - Thu, 2019-05-23 13:38
Once again elections are being battered and political views polarized by far-right propaganda flooding social media – could a simple tweak to online connections help win the information wars?
Categories: Biology