Validation of double digest selective label database for sequenced prokaryotic genomes - Summary: A database for simulation of double digest selective label (DDSL) typing technique has been created and validated against a sequenced strain (Salmonella enterica serovar Typhimurium strain LT2).
DR-Integrator: a new analytic tool for integrating DNA copy number and gene expression data - Summary: DNA copy number alterations (CNA) frequently underlie gene expression changes by increasing or decreasing gene dosage.
Fortunately, R package developers finally got to the problem of parallel computations. An excerpt (below) from a recent Bioinformatics article is a good illustration.
webMGR: an online tool for the multiple genome rearrangement problem - Summary: The algorithm MGR enables the reconstruction of rearrangement phylogenies based on gene or synteny block order in multiple genomes.
Tmod: toolbox of motif discovery - Summary: Motif discovery is an important topic in computational transcriptional regulation studies.
Accurate recognition of cis-regulatory motifs with the correct lengths in prokaryotic genomes - We present a new computational method for solving a classical problem, the identification problem of cis-regulatory motifs in a given set of promoter sequences, based on one key new idea.
Optimizing nucleotide sequence ensembles for combinatorial protein libraries using a genetic algorithm - Protein libraries are essential to the field of protein engineering.
MATICCE: mapping transitions in continuous character evolution - Summary: MATICCE is a new software package in the R language for mapping phylogenetic transitions in organismal traits that have continuous distributions.
Ancestors 1.0: a web server for ancestral sequence reconstruction - Summary: The computational inference of ancestral genomes consists of five difficult steps: identifying syntenic regions, inferring ancestral arrangement of syntenic regions, aligning multiple sequences, reconstructing the insertion a
inGAP: an integrated next-generation genome analysis pipeline - Summary: We develop a novel mining pipeline, Integrative Next-generation Genome Analysis Pipeline (inGAP), guided by a Bayesian principle to detect single nucleotide polymorphisms (SNPs), insertion/deletions (indels) by comparing high-thr